2015
DOI: 10.1111/sji.12307
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Overexpression of IGF2 mRNA‐Binding Protein 2 (IMP2/p62) as a Feature of Basal‐like Breast Cancer Correlates with Short Survival

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Cited by 39 publications
(37 citation statements)
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“…IMP2 is amplified and overexpressed in many cancers and recent reports (Li et al, 2015; Liu et al, 2015; Mu et al, 2015) have pointed to a tumorogenic role in individual cancer types, often with a poor prognosis (Barghash et al, 2015; Bigagli et al, 2016; Davidson et al, 2014; Kessler et al, 2013). Consistent with the view that IMP2 contributes broadly to tumor progression, we show herein that IMP2 drives the proliferation of both MEFs and a wide and unselected cohort of cancer cell lines.…”
Section: Discussionmentioning
confidence: 99%
“…IMP2 is amplified and overexpressed in many cancers and recent reports (Li et al, 2015; Liu et al, 2015; Mu et al, 2015) have pointed to a tumorogenic role in individual cancer types, often with a poor prognosis (Barghash et al, 2015; Bigagli et al, 2016; Davidson et al, 2014; Kessler et al, 2013). Consistent with the view that IMP2 contributes broadly to tumor progression, we show herein that IMP2 drives the proliferation of both MEFs and a wide and unselected cohort of cancer cell lines.…”
Section: Discussionmentioning
confidence: 99%
“…IGF2BP2 has also been suggested to be upregulated in many solid cancers, and it plays an important role in promoting the growth, migration and metastasis of cancer [9,10,[21][22][23][24]. However, the role of IGF2BP2 in AML has not been investigated systematically.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, IGF2BP2 promotes hepatocarcinogenesis by inducing inflammation [12]. Moreover, elevated IGF2BP2 is associated with poor survival in esophageal adenocarcinoma and basal-like breast cancer patients [9,10]. Therefore, IGF2BP2 is a potential oncogene and prognostic marker in solid cancers.…”
Section: Introductionmentioning
confidence: 99%
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“…In a small study focusing on hepatocellular carcinoma (HCC), one out of two CCC samples showed overexpression of IMP2 [ 6 ]. Overexpression of IMP2 or of its splice variant p62 (also known as IMP2-2 or IGF2BP2-2) was also reported for other tumor types, such as HCC, breast, lung, and esophageal cancer [ 7 13 ]. Moreover, a tumor-promoting action of IMP2/p62 was described in HCC and glioblastoma (GBM) [ 9 , 14 ].…”
Section: Introductionmentioning
confidence: 99%