Overexpression of LINC00673 Promotes the Proliferation of Cervical Cancer Cells

Huang, Shiang Suo; Ni, Ruoxuan; Wang, Wenjie; Wang, Di; Zhao, Mei; Lei, Chengzhi; Sun, Xiufa; Huang, Changzhi; Bai, Ping; Che, Yi-Qun; Xu, Jun

doi:10.3389/fonc.2021.669739

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Huang et al found that serum levels of LINC00673 were highest in patients with cervical cancer as compared to those in patients with CIN and normal controls 32 . In addition, increased cell proliferation and cell cycle progression were also reported in SiHa and HeLa cervical cancer cell lines, which exhibited LINC00673 overexpression.…”

Section: Discussionmentioning

confidence: 99%

Impact of LINC00673 genetic variants on uterine cervical cancer clinicopathologic characteristics

Sun,

Chen,

Wang

et al. 2023

J. Cancer

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To date, no study delineates the relationships among the genetic variants of long intergenic noncoding RNA 673 ( LINC00673 ) and uterine cervical carcinogenesis as well as clinicopathological parameters and 5 years survival of cervical cancer patients in Taiwan. Therefore, the involvement of LINC00673 polymorphisms in cervical cancer was investigated. Genotypic frequencies of three LINC00673 polymorphisms rs6501551, rs9914618 and rs11655237 were determined in 199 patients including 115 patients with invasive cancer, 84 with precancerous lesions, and 274 control females using real-time polymerase chain reaction. It revealed that LINC00673 polymorphisms were not found significantly related to development of cervical cancer. Cervical cancer patients with genotypes AG/GG in LINC00673 rs6501551 had more risk to have tumor diameter larger than 4 cm as compared to those with genotype AA ( p =0.043). Cervical cancer patients with genotype GG in rs6501551 had worse 5 years survival as compared to those with genotypes AA/AG in multivariate analysis (hazard ratio: 4.70; p =0.097). However, only two patients exhibiting GG were noted, and one had mortality, another had no mortality. In conclusion, larger sample size needs to verify the associations of LINC00673 genetic variants with clinicopathological parameters and patient survival of cervical cancer for Taiwanese females.

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Section: Discussionmentioning

confidence: 99%

Impact of LINC00673 genetic variants on uterine cervical cancer clinicopathologic characteristics

Sun,

Chen,

Wang

et al. 2023

J. Cancer

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“…In previous studies, lncRNA CCAT1 SNP rs67085638 was correlated with the development of gastric cancer ( Olesiński et al, 2021 ), and lncRNA PCAT1 and its SNP rs2632159 were associated with a higher rate of colon cancer, which involves an angiogenesis process ( Yang et al, 2019 ). LINC00673, a member of the lncRNA family, can enhance the development of certain neoplasms because of its chromatin modulation and transcriptional regulation functions ( Lu et al, 2017 ; Qiao et al, 2019 ; Hsieh et al, 2021 ; Huang et al, 2021 ). LINC00673 SNP rs11655237 could alter the development of several cancers, including hepatocellular carcinoma, pancreatic cancer, and oral cancer ( Li et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy

et al. 2022

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Long noncoding RNAs (lncRNAs) have been proven to play critical roles in diabetic retinopathy (DR). This study investigated whether the single nucleotide polymorphism (SNP) of long intergenic noncoding RNA 00673 (LINC00673) affects the clinical characteristics of diabetic retinopathy (DR). A total of three loci of LINC00673 SNPs (rs6501551, rs9914618, and rs11655237) were genotyped using TaqMan allelic discrimination in 276 and 454 individuals with and without DR, respectively. Our results revealed that LINC00673 SNP rs11655237 CT genotype (AOR: 1.592, 95% CI: 1.059–2.395, p = 0.026), CT + TT genotype (AOR: 1.255, 95% CI: 1.029–1.531, p = 0.025), and allele T (AOR: 1.185, 95% CI: 1.004–1.397, p = 0.044) yielded higher ratios in the non-proliferative diabetic retinopathy (NPDR) subgroup than in the non-DR group. Furthermore, the interval of diabetes mellitus (DM) was significantly shorter in the LINC00673 SNP rs11655237 CT + TT variant than that in the LINC00673 SNP rs11655237 wild type (10.44 ± 7.10 vs. 12.98 ± 8.34, p = 0.009). In conclusion, the LINC00673 SNP rs11655237 T allele is associated with a higher probability of NPDR development. Patients with the LINC00673 SNP rs11655237 CT + TT variant exhibited a short DM interval.

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Transcriptomic analysis reveals regulation of adipogenesis via long non-coding RNA, alternative splicing, and alternative polyadenylation

Mostafa,

Wang,

Tian

et al. 2024

Sci Rep

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Obesity is characterized by dysregulated adipogenesis that leads to increased number and/or size of adipocytes. Understanding the molecular mechanisms governing adipogenesis is therefore key to designing therapeutic interventions against obesity. In our study, we analyzed 3’-end sequencing data that we generated from human preadipocytes and adipocytes, as well as previously published RNA-seq datasets, to elucidate mechanisms of regulation via long non-coding RNA (lncRNA), alternative splicing (AS) and alternative polyadenylation (APA). We discovered lncRNAs that have not been previously characterized but may be key regulators of white adipogenesis. We also detected 100 AS events and, using motif enrichment analysis, identified RNA binding proteins (RBPs) that could mediate exon skipping—the most prevalent AS event. In addition, we show that usage of alternative poly(A) sites in introns or 3’-UTRs of key adipogenesis genes leads to isoform diversity, which can have significant biological consequences on differentiation efficiency. We also identified RBPs that may modulate APA and defined how 3’-UTR APA can regulate gene expression through gain or loss of specific microRNA binding sites. Taken together, our bioinformatics-based analysis reveals potential therapeutic avenues for obesity through manipulation of lncRNA levels and the profile of mRNA isoforms via alternative splicing and polyadenylation.

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Overexpression of LINC00673 Promotes the Proliferation of Cervical Cancer Cells

Cited by 5 publications

References 24 publications

Impact of LINC00673 genetic variants on uterine cervical cancer clinicopathologic characteristics

Impact of LINC00673 genetic variants on uterine cervical cancer clinicopathologic characteristics

Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy

Transcriptomic analysis reveals regulation of adipogenesis via long non-coding RNA, alternative splicing, and alternative polyadenylation

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