Overexpression of LncRNA SNHG1 Were Suitable for Oncolytic Adenoviruse H101 Therapy in Oral Squamous-Cell Carcinoma

Wang, Xin; Song, Yang; Lv, Xuechao; Wang, Lina; Li, Chunmei

doi:10.2147/ott.s285536

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…Previous studies have focused on OSCC protein-coding genes (5,6). Recent studies have shown that lncRNA may serve an important role in the pathogenesis of OSCC (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Maternally expressed 3 inhibits the biological activity of oral squamous cell carcinoma SCC25 and CAL27 cell lines

Wang

Li²,

Qiu

et al. 2021

Oncol Lett

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The abnormal expression of long non-coding RNA (lncRNA) maternally expressed 3 (MEG3) is closely related to several tumor diagnosis and progression, such as endometrial carcinoma and ovarian cancer. However, the role of MEG3 in oral squamous cell carcinoma (OSCC) is rarely reported. The current study aimed to evaluate the expression of lncRNA MEG3 in OSCC tissues and cell lines and its effect on the biological behavior of OSCC cell lines. The expression of lncRNA MEG3 in the OSCC tissues and cell lines was detected by reverse transcription-quantitative (RT-q) PCR. The relationship between MEG3 expression and the clinicopathologic characteristics and prognosis of patients with OSCC was analyzed. The lncRNA MEG3 overexpression plasmid and control plasmid were transfected into SCC25 and CAL27 cell lines using the lipofectin method. MTT assay was performed to detect the growth and proliferation of the cell lines. Transwell chamber test was used to detect changes in cell migration and invasion. Flow cytometry was employed to detect changes in apoptosis. Western blotting and RT-qPCR were conducted to detect the expression of the p53 gene. The expression of lncRNA MEG3 in the OSCC tissues and cell lines was significantly compared with normal tissues and cell lines, respectively. The expression level of MEG3 was related to clinical stage, lymph node metastasis, distant metastasis and survival status. Overexpression of lncRNA MEG3 inhibited the proliferation, migration, and invasion of SCC25 and CAL27 cell lines, induced apoptosis and promoted the expression of p53 gene. lncRNA MEG3 played the role of a tumor inhibitor gene and significantly inhibited the biological activity of OSCC cell lines, which may provide a novel idea for molecular targeted therapy of OSCC.

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“…Previous studies have focused on OSCC protein-coding genes (5,6). Recent studies have shown that lncRNA may serve an important role in the pathogenesis of OSCC (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Maternally expressed 3 inhibits the biological activity of oral squamous cell carcinoma SCC25 and CAL27 cell lines

Wang

Li²,

Qiu

et al. 2021

Oncol Lett

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“…Recent studies have revealed high expression of the oncogene SNHG1 in OSCC. More importantly, Wang et al (2020) also found that H101 could exert better antitumor effects in OSCC with high SNHG1 expression. Onyx-015 is an adenovirus with the E1B…”

Section: Oncolytic Viral Therapymentioning

confidence: 90%

Current status and perspective of tumor immunotherapy for head and neck squamous cell carcinoma

Zhang

et al. 2022

Front. Cell Dev. Biol.

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Head and neck squamous cell carcinoma (HNSCC) have a high incidence and mortality rate, and investigating the pathogenesis and potential therapeutic strategies of HNSCC is required for further progress. Immunotherapy is a considerable therapeutic strategy for HNSCC due to its potential to produce a broad and long-lasting antitumor response. However, immune escape, which involves mechanisms including dyregulation of cytokines, perturbation of immune checkpoints, and recruitment of inhibitory cell populations, limit the efficacy of immunotherapy. Currently, multiple immunotherapy strategies for HNSCC have been exploited, including immune checkpoint inhibitors, costimulatory agonists, antigenic vaccines, oncolytic virus therapy, adoptive T cell transfer (ACT), and epidermal growth factor receptor (EGFR)-targeted therapy. Each of these strategies has unique advantages, and the appropriate application of these immunotherapies in HNSCC treatment has significant value for patients. Therefore, this review comprehensively summarizes the mechanisms of immune escape and the characteristics of different immunotherapy strategies in HNSCC to provide a foundation and consideration for the clinical treatment of HNSCC.

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“…Of these, SNHG1 can play its biological role via molecular mechanisms such as methylation [ 21 , 36 ], demethylation [ 51 ], and ubiquitination [ 45 ] in epigenetics. In the field of chemotherapy, SNHG1 has research potential [ 52 , 66 ]. These molecular mechanisms are worthy of in-depth exploration in the future.…”

Section: Discussionmentioning

confidence: 99%

LncRNA SNHG1: role in tumorigenesis of multiple human cancers

Zeng,

Zhou,

Cai

et al. 2023

Cancer Cell Int

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Small nucleolar RNA host gene 1 (SNHG1) is an important member of the SNHG family. This family is composed of a group of host genes that can be processed into small nucleolar RNAs and play important biological functions. In an oncogenic role, the SNHG1 expression is increased in various cancers, which has immense application prospects in the diagnosis, treatment, and prognosis of malignant tumors. In this review, we have summarized the role and molecular mechanism of SNHG1 in the development of various cancers. In addition, we have emphasized the clinical significance of SNHG1 in cancers in our article. This molecule is expected to be a new marker for potential usage in the diagnosis, prognosis, and treatment of cancer.

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Overexpression of LncRNA SNHG1 Were Suitable for Oncolytic Adenoviruse H101 Therapy in Oral Squamous-Cell Carcinoma

Cited by 9 publications

References 26 publications

Maternally expressed 3 inhibits the biological activity of oral squamous cell carcinoma SCC25 and CAL27 cell lines

Maternally expressed 3 inhibits the biological activity of oral squamous cell carcinoma SCC25 and CAL27 cell lines

Current status and perspective of tumor immunotherapy for head and neck squamous cell carcinoma

LncRNA SNHG1: role in tumorigenesis of multiple human cancers

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