Overexpression of long non-coding RNA MCM3AP-AS1 in breast cancer tissues compared to adjacent non-tumour tissues

Riahi, Atousa; Feizi, Mohammad Ali Hosseinpour; Rajabi, Ali; Akbarzadeh, Moloud; Montazeri, Vahid; Safaralizadeh, Reza

doi:10.1080/09674845.2020.1798058

Cited by 17 publications

(10 citation statements)

References 26 publications

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“…It is worth noting that protein-coding genes are not the sole drivers for cancer. Breast cancer is also related to the expressions of non-coding RNAs, include repetitive DNA , transposable element (Karakulah et al, 2019), micro RNA (Aslan et al, 2020) and Long non-coding RNA (Riahi et al, 2020),etc. In this study, we have found that the expressions of NUF2 and FAM83D are associated with triple-negative breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Identification of NUF2 and FAM83D as potential biomarkers in triple-negative breast cancer

Zhai

Yang

Liu

et al. 2020

PeerJ

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Background Breast cancer is a heterogeneous disease. Compared with other subtypes of breast cancer, triple-negative breast cancer (TNBC) is easy to metastasize and has a short survival time, less choice of treatment options. Here, we aimed to identify the potential biomarkers to TNBC diagnosis and prognosis. Material/Methods Three independent data sets (GSE45827, GSE38959, GSE65194) were downloaded from the Gene Expression Omnibus (GEO). The R software packages were used to integrate the gene profiles and identify differentially expressed genes (DEGs). A variety of bioinformatics tools were used to explore the hub genes, including the DAVID database, STRING database and Cytoscape software. Reverse transcription quantitative PCR (RT-qPCR) was used to verify the hub genes in 14 pairs of TNBC paired tissues. Results In this study, we screened out 161 DEGs between 222 non-TNBC and 126 TNBC samples, of which 105 genes were up-regulated and 56 were down-regulated. These DEGs were enriched for 27 GO terms and two pathways. GO analysis enriched mainly in “cell division”, “chromosome, centromeric region” and “microtubule motor activity”. KEGG pathway analysis enriched mostly in “Cell cycle” and “Oocyte meiosis”. PPI network was constructed and then 10 top hub genes were screened. According to the analysis results of the Kaplan-Meier survival curve, the expression levels of only NUF2, FAM83D and CENPH were associated with the recurrence-free survival in TNBC samples (P < 0.05). RT-qPCR confirmed that the expression levels of NUF2 and FAM83D in TNBC tissues were indeed up-regulated significantly. Conclusions The comprehensive analysis showed that NUF2 and FAM83D could be used as potential biomarkers for diagnosis and prognosis of TNBC.

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Section: Discussionmentioning

confidence: 99%

Identification of NUF2 and FAM83D as potential biomarkers in triple-negative breast cancer

Zhai

Yang

Liu

et al. 2020

PeerJ

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“…In conclusion, MCM3AP-AS1 expression was markedly elevated in breast cancer (Chen et al, 2020;Riahi et al, 2021), Burkitt lymphoma (Guo et al, 2020), gastric cancer (Wang et al, 2020;Sun et al, 2021), glioblastoma (Yang et al, 2017), HCC (Wang et al, 2019e), LC (Li et al, 2020b), nasopharyngeal carcinoma (Sun et al, 2020), pancreatic cancer (Yang et al, 2019), papillary thyroid cancer (Liang et al, 2019), and PCa (Li et al, 2020a;Wu et al, 2020). However, MCM3AP-AS1 expression was downregulated in CSCC patients (Lan et al, 2020) (Table 1).…”

Section: Other Cancersmentioning

confidence: 83%

“…Breast cancer is one of the most common types of malignancy in women worldwide (Liang et al, 2020;Carreira et al, 2021;Han et al, 2021). The levels of lncRNA MCM3AP-AS1 are significantly upregulated in breast cancer tissues and cell lines (Chen et al, 2020;Riahi et al, 2021). The level of MCM3AP-AS1 was positively associated with estrogen receptor (ER) and progesterone receptor (PR) expression, whereas no significant differences were observed between MCM3AP-AS1 and HER2 expression profiles in breast cancer patients.…”

Section: Breast Cancermentioning

confidence: 99%

MCM3AP-AS1: An Indispensable Cancer-Related LncRNA

Zheng

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 nucleotides that have no protein-coding ability. MCM3AP-AS1, a novel lncRNA, is aberrantly expressed in human cancers. It is significantly associated with many clinical characteristics, such as tumor size, tumor-node-metastasis (TNM) stage, and pathological grade. Additionally, it considerably promotes or suppresses tumor progression by controlling the biological functions of cells. MCM3AP-AS1 is a promising biomarker for cancer diagnosis, prognosis evaluation, and treatment. In this review, we briefly summarized the published studies on the expression, biological function, and regulatory mechanisms of MCM3AP-AS1. We also discussed the clinical applications of MCM3AP-AS1 as a biomarker.

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“…MCM3AP antisense RNA 1 (MCM3AP‐AS1) has been reported for the first time to promote angiogenesis in glioblastoma 17 . It was then confirmed to play a carcinogenic role in gastric cancer, breast cancer, pancreatic cancer, and hepatocellular carcinoma 18‐21 . All these studies reveal the significant roles of MCM3AP‐AS1 in human cancers.…”

Section: Introductionmentioning

confidence: 94%

“…17 It was then confirmed to play a carcinogenic role in gastric cancer, breast cancer, pancreatic cancer, and hepatocellular carcinoma. [18][19][20][21] All these studies reveal the significant roles of MCM3AP-AS1 in human cancers. However, its role in CRC was still not fully investigated, and the mechanism remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA MCM3AP‐AS1 enhances cell proliferation and metastasis in colorectal cancer by regulating miR‐193a‐5p/SENP1

et al. 2021

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Overexpression of long non-coding RNA MCM3AP-AS1 in breast cancer tissues compared to adjacent non-tumour tissues

Cited by 17 publications

References 26 publications

Identification of NUF2 and FAM83D as potential biomarkers in triple-negative breast cancer

Identification of NUF2 and FAM83D as potential biomarkers in triple-negative breast cancer

MCM3AP-AS1: An Indispensable Cancer-Related LncRNA

Long noncoding RNA MCM3AP‐AS1 enhances cell proliferation and metastasis in colorectal cancer by regulating miR‐193a‐5p/SENP1

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