Overexpression of Matrix Metalloproteinase-21 is Associated with Poor Overall Survival of Patients with Colorectal Cancer

Huang, Yi; Li, Wenhai; Chu, Dake; Zheng, Jun; Ji, Gang; Li, Mengbin; Zhang, Hongwei; Wang, Weizhong; Du, Jianjun; Li, Jipeng

doi:10.1007/s11605-011-1519-5

Cited by 23 publications

(22 citation statements)

References 33 publications

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“…Interestingly, compared with the cleavage peptide (LAQAVRSS), we found that the prodomain of MMP21 has a similar peptide sequence (LAQAVR) through the Swiss Prot database. Furthermore, MMP21 was recently shown to play an important role in tumor processing [14][15][16]26]. In our study, MMP21 was found to be upregulated in hepatocellular carcinoma and associated with microvascular invasion.…”

Section: Discussionsupporting

confidence: 59%

ADAM17 promotes the metastasis of hepatocellular carcinoma via upregulation MMP21

Xiang

Liu

Wang

et al. 2020

Preprint

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Background The upregulation of ADAM17 has been reported to be associated with invasion and metastasis in various tumors, however the molecular mechanism of ADAM17 in the progression of hepatocellular carcinoma (HCC) remain to be clarified. Human matrix metalloproteinase 21 (MMP21), the newest member of the MMP gene family, has been suggested to play an important role in embryogenesis and tumor progression. So far, nothing is known about the relationship between ADAM17 and MMP21. Methods In this study, the expression level of ADAM17 and MMP21 in HCC tissues was measured by immunohistochemistry. The Scratch wounding assay and Transwell were used to identify the invasion and metastasis ability. ELISA was used to evaluate the production of MMP21. Coimmunoprecipitation experiments demonstrated a direct association between ADAM17 and MMP21. HPLC was used to conﬁrmed that ADAM17 participated in the maturation of MMP21. Results Our present data indicated that ADAM17 and MMP21 was significantly upregulated in human HCC tissues. Knockdown of ADAM17 in HCC inhibited cell invasion and metastasis. Moreover, ADAM17 regulates the secretion and expression of MMP21. Furthermore we discovered a direct association between ADAM17 and MMP21, and we also found MMP21 prodomain could be cleaved by ADAM17. Conclusion Our data suggest that ADAM17 plays an important role in the development of HCC invasion and metastasis and this function may be implement by MMP21.

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Section: Discussionsupporting

confidence: 59%

ADAM17 promotes the metastasis of hepatocellular carcinoma via upregulation MMP21

Xiang

Liu

Wang

et al. 2020

Preprint

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“…Current staging systems for CRC that are based on clinical and pathologic findings may have reached their limit of usefulness for predicting outcomes 23. Recent studies indicate that biomarkers are useful predicting factors, with some found to be even superior to AJCC stage 24–27. Thus, a substantial amount of research on CRC has focused on the discovery of specific biomarkers.…”

Section: Discussionmentioning

confidence: 99%

High expression of CD73 as a poor prognostic biomarker in human colorectal cancer

Chen

et al. 2012

Journal of Surgical Oncology

149

102

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“…In several human tumors, including colorectal cancer, breast cancer, prostate cancer, pancreatic cancer, Merkel cell carcinoma, hepatocellular carcinoma, up-regulated levels of MMP-21 have been found, generally in association with poor prognosis (Bister et al, 2007;Hegedüs et al, 2008;Huang et al, 2011;Suomela et al, 2009;Wu et al, 2011b).…”

Section: Neoplastic Diseasesmentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

210

212

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a b s t r a c tHuman matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to their cellular compartmentalization and/or cellular type where they are expressed. An extensive review of the different MMPs structural and functional features is integrated with their pathological role in several types of diseases, spanning from cancer to cardiovascular diseases and to neurodegeneration. It emerges a very complex and crucial role played by these enzymes in many physiological and pathological processes.

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Overexpression of Matrix Metalloproteinase-21 is Associated with Poor Overall Survival of Patients with Colorectal Cancer

Abstract: Our findings emphasize the important role of MMP-21 in the invasion and metastasis process in human colorectal cancer. It might also serve as a novel prognostic marker that is independent of, and additive to, the TNM staging system.

Cited by 23 publications

References 33 publications

ADAM17 promotes the metastasis of hepatocellular carcinoma via upregulation MMP21

ADAM17 promotes the metastasis of hepatocellular carcinoma via upregulation MMP21

High expression of CD73 as a poor prognostic biomarker in human colorectal cancer

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

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