Overexpression of microRNA-100 predicts an unfavorable prognosis in renal cell carcinoma

Wang, Guihua; Chen, Lianhua; Meng, Jing; Chen, Min; Zhuang, Lei; Zhang, Liqin

doi:10.1007/s11255-012-0374-y

Cited by 37 publications

(30 citation statements)

References 15 publications

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“…Cell Physiol Biochem 2015; 37:2143-2159 of miR-100 has been also found in small cell lung cancer (SCLC) [82], NSCLC [83,84], GC [7,9,85], HCC [86], pancreatic adenocarcinoma [87][88][89], renal cell carcinoma (RCC) [90], acute myeloid leukemia (AML) [91][92][93][94]. However, the expression levels of miR-100 in the same cancer type could be different, which is dependent on the tumor samples obtaining in cancer cell lines or in cancer tissues, as well as plasma.…”

Section: Table 1 Dysregulation Of Mir-100 In Different Human Cancersmentioning

confidence: 99%

“…In terms of SCLC, Xiao et al confirmed that the expression level of miR-100 was inversely correlated with the expression of its target gene HOXA1 and associated with the poor prognosis of SCLC patients [82]. Wang et al showed that overexpression of miR-100 in RCC tissues was associated with advanced tumor T stage, grade, the presence of metastasis and poor prognosis of patients [90]. Moreover, low expression of miR-100 was testified to be a negative prognostic factor, associating with gene signatures of high grade undifferentiated breast cancer [34].…”

Section: Mir-100 In Cancer Diagnosis and Prognosismentioning

confidence: 99%

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Multiple Roles of MicroRNA-100 in Human Cancer and its Therapeutic Potential

Li¹,

Gao²,

Zhang³

et al. 2015

Cell Physiol Biochem

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MicroRNAs (miRNAs) are a recently discovered class of endogenous, small (about 22 nucleotides) non-coding RNAs, which play important roles in cancer development and progression. Emerging evidence shows that microRNAs exert their regulatory effects by directly binding to the 3'- untranslated regions (UTRs) of their target genes. MicroRNA-100 (miR-100) is aberrantly expressed and functions in many human cancers by regulating multiple cell processes, such as cell cycle, proliferation, differentiation, migration, invasion and apoptosis, via post-transcriptionally regulating various target genes. A better understanding of the molecular mechanisms involved in miR-100-mediated tumor progression will provide an opportunity for exploring novel miR-100-based targeted therapies for human cancers. This review aims to summarize the recently published literature on the roles of miR-100 in regulating tumorigenesis, and explore its potential clinical applications for cancer diagnosis, prognosis and clinical treatment.

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Section: Table 1 Dysregulation Of Mir-100 In Different Human Cancersmentioning

confidence: 99%

Section: Mir-100 In Cancer Diagnosis and Prognosismentioning

confidence: 99%

Multiple Roles of MicroRNA-100 in Human Cancer and its Therapeutic Potential

Li¹,

Gao²,

Zhang³

et al. 2015

Cell Physiol Biochem

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“…In breast cancer, silencing of miR-100 initiated apoptosis [106] and the same effect was also observed in gastric tumour [107]. High miR-100 expression in renal carcinoma cells was associated with poorer prognosis [108], but not in hepatocellular carcinoma where downregulation of miR-100 was associated with poorer cell differentiation and shorter recurrence-free survival, while activation of miR-100 repressed metastasis [109]. In oesophageal squamous cell carcinoma [110], colorectal cancer [111], bladder carcinoma [112] and ovarian cancer [113] miR-100 downregulation was generally found to be associated with a poorer prognosis.…”

Section: Introductionmentioning

confidence: 97%

11q deletion in neuroblastoma: a review of biological and clinical implications

et al. 2017

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Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is associated with higher disease stage and decreased survival probability. During the last 25 years, extensive efforts have been invested to identify the precise frequency of 11q aberrations in neuroblastoma, the recurrently involved genes, and to understand the molecular mechanisms of 11q deletion, but definitive answers are still unclear. In this review, it is our intent to compile and review the evidence acquired to date on 11q deletion in neuroblastoma.

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“…In addition to these, the downregulation of miR-100 was also shown in hepatocellular carcinoma, oral cancer, and adrenocortical cancer (Henson et al, 2009;Doghman et al, 2010;Chen et al, 2013). In contrast, an upregulation of miR-100 has been observed in renal cell carcinoma, acute myeloid leukemia, and prostate cancer (Akbari Moqadam et al, 2013;Wang et al, 2013;Wang et al, 2014). Previously, Oliveira et al (2011) found that miR-100 acted as a tumor suppressor in human bladder carcinoma 5637 cells.…”

Section: Discussionmentioning

confidence: 96%

Prognostic role of microRNA-100 in patients with bladder cancer

Cao¹,

Zhang²,

Xu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the clinical significance and prognostic value of microRNA-100 (miR-100) in bladder cancer. Quantitative realtime polymerase chain reaction was used to analyze the expression of miR-100 in 92 pairs of human bladder cancer and adjacent normal tissue samples. Overall survival (OS) curves were plotted using the Kaplan-Meier method and were evaluated for statistical significance using a log-rank test. The significance of different variables with respect to survival was analyzed using the multivariate Cox proportional hazard model. The miR-100 expression level was significantly lower in bladder cancer tissues than in normal adjacent tissues (mean ± SD: 1.49 ± 0.52 vs 2.79 ± 0.59, P < 0.05). A low miR-100 expression level was correlated with tumor stage (P = 0.023), tumor grade (P = 0.031), and regional lymph node involvement (P = 0.16). Kaplan-Meier analysis with log-rank test indicated that low miR-100 expression had a significant impact on OS (35.1 vs 75.3%; P = 0.004). Multivariate analysis revealed that the miR-100 expression level was an independent prognostic factor for OS (HR = 2.768, 95%CI = 1.287-8.992; P = 0.009) in bladder cancer patients. The present study demonstrated that the downregulation of miR-100 was associated with advanced clinical features and poor prognosis for bladder cancer patients, suggesting that 15949 Prognostic role of miR-100 in bladder cancer ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 15948-15954 (2015) miR-100 downregulation may be used as an unfavorable prognostic biomarker in bladder cancer.

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Overexpression of microRNA-100 predicts an unfavorable prognosis in renal cell carcinoma

Abstract: Our data offer convincing evidence that miR-100 overexpression strongly associates with advanced tumor progression and unfavorable clinical outcome of patients with RCC. miR-100 expression may be a useful prognostic marker for this disease.

Cited by 37 publications

References 15 publications

Multiple Roles of MicroRNA-100 in Human Cancer and its Therapeutic Potential

Multiple Roles of MicroRNA-100 in Human Cancer and its Therapeutic Potential

11q deletion in neuroblastoma: a review of biological and clinical implications

Prognostic role of microRNA-100 in patients with bladder cancer

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