2019
DOI: 10.1016/j.bbrc.2019.01.139
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Overexpression of miR-1258 inhibits cell proliferation by targeting AKT3 in osteosarcoma

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Cited by 27 publications
(23 citation statements)
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“…Aberration in miRNA expression has been consistently reported in many types of human cancer including OS. [29][30][31] miRNAs may play either oncogenic or tumor suppressive roles and contribute in the regulation of malignant behavior of OS cells. [32][33][34] Strategies for prohibiting different types of human malignancy using miRNAs have been proposed in several literatures.…”
Section: Discussionmentioning
confidence: 99%
“…Aberration in miRNA expression has been consistently reported in many types of human cancer including OS. [29][30][31] miRNAs may play either oncogenic or tumor suppressive roles and contribute in the regulation of malignant behavior of OS cells. [32][33][34] Strategies for prohibiting different types of human malignancy using miRNAs have been proposed in several literatures.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, studies have indicated that miRNAs have a marked effect on modulating cellular functions and biological processes during the progression of tumors 8,9 . Moreover, increasing evidence has demonstrated that abnormal expression of miRNAs is closely related to cell proliferation, migration, invasion, and prognosis in OS 13,14,48,49 . Although some studies have implicated miR-210-5p in various tumors, the underlying functions and mechanisms of miR-210-5p in OS have not yet been investigated.…”
Section: Discussionmentioning
confidence: 99%
“…Accumulating evidence suggests that miRNAs act as oncogenes in various tumors 11,12 . Recent studies also identified miRNAs which may regulate cell proliferation, metastasis, and apoptosis in the development of OS [13][14][15][16] . MiR-210-5p, an onco-miR, which was reported to be increased in several malignant tumors, was shown to be significantly correlated with poor clinical outcomes [17][18][19][20] .…”
Section: Introductionmentioning
confidence: 99%
“…In vitro assays demonstrated that miR-1258 expression negatively correlated with metastasis of HCC cells. MiR-1258 regulates cell cycle progression and inhibits cell proliferation, and suppresses tumor metastasis in many cancer types [16][17][18]. In this study, we screened the targets of miR-1258 by online tools.…”
Section: Discussionmentioning
confidence: 99%