Overexpression of miR-490-5p/miR-490-3p Potentially Induces IL-17-Producing T Cells in Patients With Breast Cancer

Seif, Farhad; Vaseghi, Hajar; Ariana, Mehdi; Ganji, Shahla Mohammad; Nazari, Mohammad; Rad, Kowsar Kiani; Pornour, Majid

doi:10.4274/ejbh.galenos.2022.2021-10-4

Cited by 3 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Th17 is one of the subgroups of CD4 + T cells with some crucial activities in inflammation, autoimmunity, graft-versus-host disease (GVHD), and cancer progression [159][160][161]. IL-17 is the most important cytokine that is secreted from Th17 cells that has a critical role in the angiogenesis, proliferation, and metastasis of several cancers.…”

Section: T Lymphocytes (Exhausted Regulatory and γδ T Cells)mentioning

confidence: 99%

The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways

Bakhtiyari,

Liaghat,

Aziziyan

et al. 2023

Cell Commun Signal

Self Cite

View full text Add to dashboard Cite

Acute myeloid leukemia (AML) comprises a multifarious and heterogeneous array of illnesses characterized by the anomalous proliferation of myeloid cells in the bone marrow microenvironment (BMM). The BMM plays a pivotal role in promoting AML progression, angiogenesis, and metastasis. The immune checkpoints (ICs) and metabolic processes are the key players in this process. In this review, we delineate the metabolic and immune checkpoint characteristics of the AML BMM, with a focus on the roles of BMM cells e.g. tumor-associated macrophages, natural killer cells, dendritic cells, metabolic profiles and related signaling pathways. We also discuss the signaling pathways stimulated in AML cells by BMM factors that lead to AML progression. We then delve into the roles of immune checkpoints in AML angiogenesis, metastasis, and cell proliferation, including co-stimulatory and inhibitory ICs. Lastly, we discuss the potential therapeutic approaches and future directions for AML treatment, emphasizing the potential of targeting metabolic and immune checkpoints in AML BMM as prognostic and therapeutic targets. In conclusion, the modulation of these processes through the use of directed drugs opens up new promising avenues in combating AML. Thereby, a comprehensive elucidation of the significance of these AML BMM cells' metabolic and immune checkpoints and signaling pathways on leukemic cells can be undertaken in the future investigations. Additionally, these checkpoints and cells should be considered plausible multi-targeted therapies for AML in combination with other conventional treatments in AML.

show abstract

Section: T Lymphocytes (Exhausted Regulatory and γδ T Cells)mentioning

confidence: 99%

The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways

Bakhtiyari,

Liaghat,

Aziziyan

et al. 2023

Cell Commun Signal

Self Cite

View full text Add to dashboard Cite

show abstract

“…Seif et al found that overexpression of miR-490-5p and miR-490-3p in peripheral blood mononuclear cells (PBMC) and plasma from BC patients led to the production of Th17 lymphocytes and IL-17-producing regulatory T cells (Tregs). This immune response reduced the levels of CD3d, IL-2, IL-2 receptor chain alpha, forkhead box O1 (FOXO1) , and nuclear factor of activated T cells 5 (NFAT5) ; a microenvironment that supports tumor progression ( 209 ). Soheilifar et al reported that overexpression of miR-182-5p and miR-182-3p suppresses the FOXO1, NFATs, and IL-2/IL-2RA signaling pathways.…”

Section: Interplay Between Mirnas and Ros In Breast Cancermentioning

confidence: 99%

A vicious circle in breast cancer: The interplay between inflammation, reactive oxygen species, and microRNAs

et al. 2022

View full text Add to dashboard Cite

Breast cancer (BC) is the most common cancer in women worldwide. This highly heterogeneous disease is molecularly stratified into luminal A, luminal B, HER2, triple-negative/basal-like, and normal-like subtypes. An important aspect in BC progression is the activation of inflammatory processes. The activation of CD8+/Th1, NK, and M1 tumor associated macrophages (TAMs), leads to tumor destruction. In contrast, an anti-inflammatory response mediated by CD4+/Th2 and M2 TAMs will favor tumor progression. Inflammation also stimulates the production of inflammatory mediators like reactive oxygen species (ROS). In chronic inflammation, ROS activates oxidative stress and endothelial dysfunction. In cancer, ROS plays a dual role with anti-tumorigenic and pro-tumorigenic effects in cell signaling pathways that control proliferation, survival, apoptosis, and inflammation. MicroRNAs (miRNAs), which are known to be involved in BC progression and inflammation, can be regulated by ROS. At the same time, miRNAs regulate the expression of genes modulating oxidative stress. In this review, we will discuss the interplay between inflammation, ROS, and miRNAs as anticancer and tumor promoter molecules in BC. A clear understanding of the role of miRNAs in the regulation of ROS production and inflammation, may lead to new opportunities for therapy in BC.

show abstract

Role of low‐density cholesterol and Interleukin‐17 interaction in breast cancer pathogenesis and treatment

Liu,

Yang,

Wang

et al. 2024

Cell Biology International

View full text Add to dashboard Cite

Breast cancer (BC) has become the most prevalent cancer worldwide, and further research is being conducted to deepen our understanding of its pathogenesis and treatment. Lipid metabolism disorder is a significant alteration in cancer cells, and the investigation into the role of Interleukin‐17 (IL‐17) in malignant tumors has emerged as a research focus in recent years. Thus, exploring changes in lipid metabolism and inflammatory factors in BC cells is crucial in identifying potential therapeutic targets. This article summarizes the progress made in the research on the main low‐density cholesterol (LDL) transporter and IL‐17 in lipid metabolism, and their potential involvement in the development of BC. The article aims to establish a theoretical foundation for the development of BC‐related therapies.

show abstract

Overexpression of miR-490-5p/miR-490-3p Potentially Induces IL-17-Producing T Cells in Patients With Breast Cancer

Cited by 3 publications

References 31 publications

The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways

The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways

A vicious circle in breast cancer: The interplay between inflammation, reactive oxygen species, and microRNAs

Role of low‐density cholesterol and Interleukin‐17 interaction in breast cancer pathogenesis and treatment

Contact Info

Product

Resources

About