Overexpression of miR-664 is associated with enhanced osteosarcoma cell migration and invasion ability via targeting SOX7

Bao, Yongzheng; Chen, Bin; Wu, Qiang; Hu, Konghe; Xi, Xinhua; Zhu, Wengang; Zhong, Xueren; Chen, Jianting

doi:10.1007/s10238-015-0398-6

Cited by 27 publications

(26 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[8][9][10] So, miRNA therapeutics broad a new era for the management of cancer. [12][13][14][15] However, the precise role and mechanism of miR-664a-3p in gastric cancer have not been elucidated. [12][13][14][15] However, the precise role and mechanism of miR-664a-3p in gastric cancer have not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: miR‐664a‐3p functions as an oncogene by targeting Hippo pathway in the development of gastric cancer

Wang

Zhang

et al. 2019

Cell Proliferation

View full text Add to dashboard Cite

Objectives: It has been accounted that miR-664a-3p has different functions in several malignancies; however, the precise role and underlying mechanism in gastric cancer have not been elucidated. Our study aims to explore the function of miR-664a-3p on the progression of gastric cancer (GC).Methods: qRT-PCR was applied to detect the expression of miR-664a-3p in GC tissues and cells. The functions of miR-664a-3p on GC in vitro were examined by cell proliferation assay, and transwell assay. Related proteins of epithelial-mesenchymal transition (EMT) and signal pathway were evaluated by Western blot and immunofluorescence analysis. The bioinformatic, dual-luciferase assay or ChIP assay were employed to identify the interaction between miR-664a-3p and its target gene or Foxp3. The effects in vivo were investigated through a mouse tumorigenicity model. Results: miR-664a-3p was frequently upregulated in GC tissues and cells. Elevated expression of miR-664a-3p significantly promoted proliferation and invasion in vitro and in vivo. MOB1A was confirmed to be a target of miR-664a-3p and restoration of MOB1A attenuated the effects of miR-664a-3p. A series of investigations indicated that miR-664a-3p contributed to EMT process and inactivated the Hippo pathway by downregulating MOB1A. Conclusion:Taken together, we revealed that miR-664a-3p functions as an oncogene by targeting Hippo pathway in the development of gastric cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

RETRACTED: miR‐664a‐3p functions as an oncogene by targeting Hippo pathway in the development of gastric cancer

Wang

Zhang

et al. 2019

Cell Proliferation

View full text Add to dashboard Cite

show abstract

“…The 3′-UTR of human SOX7 mRNA has 1973 nucleotides (nts), markedly longer than the average 3′-UTR length (740 nts) of eukaryotic mRNAs [ 18 ], implicating its vulnerability as a target of microRNAs. Consistently, many microRNAs have been reported to inhibit SOX7 mRNA [ 19 , 20 , 21 , 22 , 23 , 24 ]. In addition, SOX7 is inhibited by a long noncoding RNA that plays an oncogenic role in human glioma [ 25 ].…”

Section: Introductionmentioning

confidence: 73%

SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function

Zhang

Stovall

Wan

et al. 2018

IJMS

View full text Add to dashboard Cite

SOX7 is a transcription factor and acts as a tumor suppressor, but its target genes in cancers are poorly explored. We revealed SOX7-mediated gene expression profile in breast cancer cells using microarray chips and discovered multiple altered signaling pathways. When combinatorially analyzing the microarray data with a gene array dataset from 759 breast cancer patients, we identified four genes as potential targets of SOX7 and validated them by quantitative PCR and chromatin immunoprecipitation assays. Among these four genes, we determined that SOX7-activated SPRY1 and SLIT2, and SOX7-repressed TRIB3 and MTHFD2 could all differentially contribute to SOX7-mediated tumor suppression. Overall, we identified multiple cancer-related pathways mediated by SOX7 and for the first time revealed SOX7-regulated target genes in a cancer-relevant context.

show abstract

“…In fact, both the role and mechanism of miR-664 in disease have been investigated in several studies. [ 25 – 28 ]…”

Section: Discussionmentioning

confidence: 99%

MiR-664a-3p expression in patients with obstructive sleep apnea

Chen

Qin

et al. 2018

Medicine

View full text Add to dashboard Cite

The early prediction of atherosclerosis (AS) is important in the management of obstructive sleep apnea patients (OSA). MicroRNA (miRNA) plays a vital role in the evolution of OSA and AS. Its differential expression may therefore serve as a diagnostic and prognostic biomarker of AS in OSA. The aim of this study was to identify specific serum miRNAs that could serve as a novel screening signature of AS in OSA patients. The specificity and sensitivity of these miRNAs in the early diagnosis of AS in OSA patients were then determined.The 128 participants in this study underwent maximum carotid intima-media thickness (CIMT) measurements and polysomnography and were divided into 4 groups: 27 healthy volunteers with normal max-CIMT, 31 healthy volunteers with increased max-CIMT, 35 OSA patients with normal max-CIMT, and 35 OSA patients with iCIMT. MiRNA was extracted from the 12 participants’ serum (3 participants each groups) and used to establish miRNA libraries for deep sequencing. A total of 116 participants were quantified by qRT- PCR. Correlations between differential expression of miRNAs and CIMT were assessed using the Spearman correlation coefficient. Our study was approved by the Ethics Committee of our hospital and was conducted in line with the Helsinki Declaration.MiR-664a-3p expression was quantified by qRT-PCR. Correlations between miR-664a-3p expression and CIMT were assessed using the Spearman correlation coefficient. The results showed that the miR-664a-3p was downregulated in the OSA, OSA with iCMIT, and nCIMT groups compared with the control group.The demonstrated potential of circulating miR-664a-3p as a noninvasive marker of AS in essential OSA patients should be confirmed in further studies.

show abstract

Overexpression of miR-664 is associated with enhanced osteosarcoma cell migration and invasion ability via targeting SOX7

Cited by 27 publications

References 33 publications

RETRACTED: miR‐664a‐3p functions as an oncogene by targeting Hippo pathway in the development of gastric cancer

RETRACTED: miR‐664a‐3p functions as an oncogene by targeting Hippo pathway in the development of gastric cancer

SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function

MiR-664a-3p expression in patients with obstructive sleep apnea

Contact Info

Product

Resources

About