Overexpression of p53 protein in gallbladder carcinoma in North India

Misra, Sanjeev; Chaturvedi, Arun; Goel, Madhumati; Mehrotra, R. M. L.; Sharma, Ira; Srivastava, Amit; Misra, N. C.

doi:10.1053/ejso.1999.0763

Cited by 42 publications

(26 citation statements)

References 21 publications

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“…Vários estudos (1,8,9,13,16,18,20,25,28,29,36,39,40,42) foram realizados para avaliar a presença de expressão da proteína p53 no CaVB, apresentando resultados conflitantes tanto em relação à sua positividade quanto à significância da imunorreatividade no prognóstico dessa neoplasia. Esse fato pode ser atribuído, em parte, a pequenas amostras estudadas.…”

Section: Discussionunclassified

“…Desde a primeira publicação realizada por Kamel et al (16) em 1993 para avaliar imuno-histoquimicamente a presença de expressão da proteína p53 no CaVB, poucas publicações (1,8,9,13,16,18,20,25,28,29,36,39,40,42) têm sido feitas, com achados bastante variáveis de positividade (entre 36,9% e 95%) e conflitantes em relação à associação dessa mutação com o prognóstico dos portadores dessa neoplasia.…”

Section: Introductionunclassified

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Expressão imuno-histoquímica e valor prognóstico da proteína p53 no carcinoma de vesícula biliar: estudo de 60 casos

Rocha¹,

Coutinho

Leboute³

et al. 2004

J. Bras. Patol. Med. Lab.

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Section: Discussionunclassified

Section: Introductionunclassified

Expressão imuno-histoquímica e valor prognóstico da proteína p53 no carcinoma de vesícula biliar: estudo de 60 casos

Rocha¹,

Coutinho

Leboute³

et al. 2004

J. Bras. Patol. Med. Lab.

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“…Data are limited regarding consistent molecular changes associated with gallbladder carcinogenesis and disease progression. In recent years, several molecular markers with prognostic impact on GBC have been described, such as Ki-67 (3), cyclin D1 (4), MUC1 (5), p53 (6,7), p16 (7), p21 (8), p27Kip1 (9), RCAS1 (10), K-ras (11), and c-erb-B2 (12).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Epithelial Cell Adhesion Molecule Antigen in Gallbladder Carcinoma Is an Independent Marker for Poor Survival

Varga

Obrist²,

Schneeberger³

et al. 2004

Clinical Cancer Research

131

101

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Purpose: Gallbladder carcinoma is an aggressive type of cancer that is difficult to cure by conventional procedures. There thus is a need to identify novel molecular markers for the assessment of prognosis and as potential therapeutic targets. This retrospective study was designed to investigate the prognostic significance of epithelial cell adhesion molecule (Ep-CAM) overexpression in human gallbladder carcinoma.Experimental Design: Ep-CAM expression was examined immunohistochemically on paraffin-embedded tissue specimens from 99 patients who underwent surgical treatment for gallbladder carcinoma in the period between August 1988 and May 1999.Results: Ep-CAM overexpression was found in 63 (63.6%) of the tumor samples. Kaplan-Meier curves showed that Ep-CAM overexpression was significantly related to decreased overall survival (P < 0.01). Overall survival gradually worsened with increasing Ep-CAM scores. Notably, in the subgroup of pT1 tumors (n ‫؍‬ 17), patients without Ep-CAM overexpression had a 5-year overall survival rate of 100% compared with 38% (P ‫؍‬ 0.01) for patients with Ep-CAM-overexpressing tumors. By univariate analysis, no correlation was found with conventional clinicopathological parameters. Multivariate analysis, including Ep-CAM expression, pT stage, tumor grade, and resection margin involvement, showed that Ep-CAM overexpression was an independent prognostic marker in gallbladder carcinoma (P ‫؍‬ 0.03; relative risk, 1.8).Conclusions: These results demonstrate for the first time that Ep-CAM overexpression is an independent prognostic marker in gallbladder carcinoma and that its prognostic impact should be validated prospectively. Furthermore, the Ep-CAM antigen represents an attractive target for specific therapies with monoclonal antibodies or specific vaccines in patients with Ep-CAM-overexpressing gallbladder carcinoma.

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“…Very few reports in the literature are available on the P.K. Mishra et al study of p53 in gallbladder cancer in Indian patients (Misra et al, 2000), and the role of cyclin-E as prognosticator in gastric cancers is debatable. Also, there is no information available on Rad50 expression in gallbladder cancer to date.…”

Section: Discussionmentioning

confidence: 99%

Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomas

Mishra

Jatawa²,

Raghuram³

et al. 2009

Genet. Mol. Res.

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ABSTRACT. Gallbladder carcinoma is an uncommon, but highly malignant tumor, with poor prognostic, and diagnostic manifestations in early stages. The Indian Council of Medical Research reported increased incidence of gallbladder carcinoma in the surviving population of the Bhopal gas tragedy that involved exposure of more than 500,000 people to methyl isocyanate gas. The severity of exposure, and increased multi-systemic morbidity in the survivors stimulated us to examine the molecular changes leading to gallbladder carcinoma. Surgically resected samples (N = 40) of gallbladder carcinoma were studied for the p53, Rad50, and cyclin-E expression by immunohistofluorescence bioimaging. Among the 40 samples, 23, 11, and 10 showed p53, Rad50, and cyclin-E expression, respectively, in moderately differentiated adenocarcinomas, demonstrating the prevalence and inva- Gallbladder carcinoma in a methyl isocyanate-exposed population siveness of this disease in the methyl isocyanate-exposed population (P = 0.0009). Nevertheless, co-expression of Rad50, and cyclin-E with p53 was absent in adenomas with dysplasia, demonstrating their independent roles. We conclude that there was altered expression of p53, Rad50, and cyclin-E in the malignant transformation of gallbladder carcinoma in this methyl isocyanate gas-exposed cohort. Hence, these proteins may be useful as markers to identify premalignant lesions that are likely to progress into malignant adenocarcinoma.

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Overexpression of p53 protein in gallbladder carcinoma in North India

Cited by 42 publications

References 21 publications

Expressão imuno-histoquímica e valor prognóstico da proteína p53 no carcinoma de vesícula biliar: estudo de 60 casos

Expressão imuno-histoquímica e valor prognóstico da proteína p53 no carcinoma de vesícula biliar: estudo de 60 casos

Overexpression of Epithelial Cell Adhesion Molecule Antigen in Gallbladder Carcinoma Is an Independent Marker for Poor Survival

Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomas

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