Overexpression of phosphorylated ATF2 and STAT3 in eccrine porocarcinoma and eccrine poroma

Significance of cyclin D1-, product of retinoblastoma (pRb), p53, p63 and p73 expression in eccrine poroma and eccrine porocarcinoma

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Significance of cyclin D1-, product of retinoblastoma (pRb), p53, p63 and p73 expression in eccrine poroma and eccrine porocarcinoma Eccrine porocarcinoma (EPC) is a rare malignant tumor arising from the intraepidermal portion of the eccrine sweat gland duct epithelium or from pre-existing eccrine poroma (EP) [1], and the precise pathogenesis remains unclear. Thus, the purpose of the present study was to investigate the possible contribution of major G1 cell cycle-regulators to the development of EP and EPC.Sectioned specimens of 17 EP (age: 56.7 AE 15.3, male/female = 11/ 6), 11 EPC (age: 72.3 AE 18.6, male/female = 4/7) and 8 normal skin (NS, age: 43.1 AE 6.9, male/female = 5/3) were subjected to immunohistochemical staining for phosphorylated (p)-pRb (Ser 608) (Cell Signaling Technology, Beverly, MA, USA), cyclin D1, p53 (Novocastra, Newcastle upon Tyne, UK), p63 (clone 4A4; LAB Vision Corporation, USA) or p73 (AB7824, Chemicon, Temecula, Australia) and were analyzed as previously described [2].Cyclin D1 and p-pRb were nuclear positive in some NS keratinocytes ( Fig. Thus, the purpose of the present study was to investigate the possible contribution of major G1 cell cycle-regulators to the development of EP and EPC.

Sectioned specimens of 17 EP (age: 56.7 AE 15.3, male/female = 11/ 6), 11 EPC (age: 72.3 AE 18.6, male/female = 4/7) and 8 normal skin (NS, age: 43.1 AE 6.9, male/female = 5/3) were subjected to immunohistochemical staining for phosphorylated (p)-pRb (Ser 608) (Cell Signaling Technology, Beverly, MA, USA), cyclin D1, p53 (Novocastra, Newcastle upon Tyne, UK), p63 (clone 4A4; LAB Vision Corporation, USA) or p73 (AB7824, Chemicon, Temecula, Australia) and were analyzed as previously described [2].

Cyclin D1 and p-pRb were nuclear positive in some NS keratinocytes ( Fig.

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“…Sectioned specimens of 17 EP (age: 56.7 AE 15.3, male/female = 11/ 6), 11 EPC (age: 72.3 AE 18.6, male/female = 4/7) and 8 normal skin (NS, age: 43.1 AE 6.9, male/female = 5/3) were subjected to immunohistochemical staining for phosphorylated (p)-pRb (Ser 608) (Cell Signaling Technology, Beverly, MA, USA), cyclin D1, p53 (Novocastra, Newcastle upon Tyne, UK), p63 (clone 4A4; LAB Vision Corporation, USA) or p73 (AB7824, Chemicon, Temecula, Australia) and were analyzed as previously described [2].…”

“…Several candidate genes have been investigated with the genomewide linkage analysis and the case-control study, and some of them have actually been revealed to have an association with leprosy at a distinct stage in a particular ethnic population, including genes of pattern recognition receptors (PRRs), especially toll-like receptors (TLRs) [2]. Several candidate genes have been investigated with the genomewide linkage analysis and the case-control study, and some of them have actually been revealed to have an association with leprosy at a distinct stage in a particular ethnic population, including genes of pattern recognition receptors (PRRs), especially toll-like receptors (TLRs) [2].…”