Overexpression of RCN1 correlates with poor prognosis and progression in non–small cell lung cancer

Chen, Xinming; Shao, Weiwei; Huang, Hua; Feng, Xin; Yao, Sumei; Ke, Honggang

doi:10.1016/j.humpath.2018.08.014

Cited by 22 publications

(36 citation statements)

References 15 publications

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“…RCN, which localized in the ER, was proven to be involved in the regulation of normal behavior and function of cells, and the RCN up-regulation may also participate in tumorigenesis, tumor invasion, and drug resistance [20]. A purposeful study confirmed that the up-regulated RCN1 was correlated with the poor prognosis and progression of nonsmall cell lung cancer [11]. ADM appears to be an effective and highly sensitive drug against NPC cells [21].…”

Section: Discussionmentioning

confidence: 93%

“…The capability of cell reaction to ER stress-mediated dysregulation is of great importance for the cell survival, because chronic or unresolved ER stress may lead to apoptosis [10]. Abnormal expression of RCN1 protein is shown to participate in multifarious diseases, including cancers, and the highly expressed RCN1 has been proved to be situated in multiple types of cancers, such as breast cancer, liver cancer, kidney cancer, as well as colorectal cancer [11]. Intriguingly, RCN1 knockdown has demonstrated to promote apoptosis and necroptosis in prostate cancer cells [12].…”

Section: Introductionmentioning

confidence: 99%

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Reticulocalbin-1 knockdown increases the sensitivity of cells to Adriamycin in nasopharyngeal carcinoma and promotes endoplasmic reticulum stress-induced cell apoptosis

et al. 2020

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Reticulocalbin-1 knockdown increases the sensitivity of cells to Adriamycin in nasopharyngeal carcinoma and promotes endoplasmic reticulum stress-induced cell apoptosis

et al. 2020

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“…The differential expression of RCN1 is correlated with cancer. RCN1 overexpression has been observed in invasive breast cancer cells (26), lung cancer cells (27), colorectal cancer cells (24), gastric cancer cells (28), liver cancer cells (29), prostate cancer cells (30), and kidney cancer (31), suggesting a role for RCN1 in tumorigenesis and invasion.…”

Section: Resultsmentioning

confidence: 99%

Salivary NUS1 and RCN1 Levels as Biomarkers for Oral Squamous Cell Carcinoma Diagnosis

Ueda

Hashimoto

Miyabe

et al. 2020

In Vivo

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Background/Aim: Oral cancer may become advanced because of delay in diagnosis. In order to promote oral cancer screening, simple and highly reliable screening methods that can be implemented at general dental clinics are required. Herein we investigated differential salivary gene expression between oral squamous cell carcinoma (OSCC) patients and healthy volunteers (HV) to identify new biomarkers for OSCC detection. Materials and Methods: Candidate genes were selected by microarrays, nuclear undecaprenyl pyrophosphate synthase 1 (NUS1) and reticulocalbin 1 (RCN1) were selected for further investigation. We used real-time quantitative reverse transcription PCR (qRT-PCR) to determine NUS1 and RCN1 expression levels in saliva and tissues. Results: qRT-PCR analysis of clinical samples revealed that OSCC patients had significantly higher expression of salivary NUS1 and RCN1 than HV. Conclusion: A combination of NUS1 and RCN1 accurately distinguished patients from controls, and this combination can be implemented as a screening test for OSCC.

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“…Of the 34 significantly differentially expressed Ψ-lnc-parent gene pairs, 25 parent genes were described in cancer. This includes lung cancer associated genes like CS , which affects tumor drug response, as well as RCN1 , which is associated with poor prognosis and tumor progression in lung cancer (Chen et al, 2014, 2018).…”

Section: Resultsmentioning

confidence: 99%

Aberrant Expression of Pseudogene-Derived lncRNAs as an Alternative Mechanism of Cancer Gene Regulation in Lung Adenocarcinoma

Stewart¹,

Enfield

Sage³

et al. 2019

Front. Genet.

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Transcriptome sequencing has led to the widespread identification of long non-coding RNAs (lncRNAs). Subsequently, these genes have been shown to hold functional importance in human cellular biology, which can be exploited by tumors to drive the hallmarks of cancer. Due to the complex tertiary structure and unknown binding motifs of lncRNAs, there is a growing disparity between the number of lncRNAs identified and those that have been functionally characterized. As such, lncRNAs deregulated in cancer may represent critical components of cancer pathways that could serve as novel therapeutic intervention points. Pseudogenes are non-coding DNA sequences that are defunct relatives of their protein-coding parent genes but retain high sequence similarity. Interestingly, certain lncRNAs expressed from pseudogene loci have been shown to regulate the protein-coding parent genes of these pseudogenes in trans particularly because of this sequence complementarity. We hypothesize that this phenomenon occurs more broadly than previously realized, and that aberrant expression of lncRNAs overlapping pseudogene loci provides an alternative mechanism of cancer gene deregulation. Using RNA-sequencing data from two cohorts of lung adenocarcinoma, each paired with patient-matched non-malignant lung samples, we discovered 104 deregulated pseudogene-derived lncRNAs. Remarkably, many of these deregulated lncRNAs (i) were expressed from the loci of pseudogenes related to known cancer genes, (ii) had expression that significantly correlated with protein-coding parent gene expression, and (iii) had lncRNA protein-coding parent gene expression that was significantly associated with survival. Here, we uncover evidence to suggest the lncRNA-pseudogene-protein-coding gene axis as a prominent mechanism of cancer gene regulation in lung adenocarcinoma, and highlights the clinical utility of exploring the non-coding regions of the cancer transcriptome.

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Overexpression of RCN1 correlates with poor prognosis and progression in non–small cell lung cancer

Cited by 22 publications

References 15 publications

Reticulocalbin-1 knockdown increases the sensitivity of cells to Adriamycin in nasopharyngeal carcinoma and promotes endoplasmic reticulum stress-induced cell apoptosis

Reticulocalbin-1 knockdown increases the sensitivity of cells to Adriamycin in nasopharyngeal carcinoma and promotes endoplasmic reticulum stress-induced cell apoptosis

Salivary NUS1 and RCN1 Levels as Biomarkers for Oral Squamous Cell Carcinoma Diagnosis

Aberrant Expression of Pseudogene-Derived lncRNAs as an Alternative Mechanism of Cancer Gene Regulation in Lung Adenocarcinoma

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