Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1α-dependent mitochondrial homeostasis in endothelial cells

Knockdown of hsa_circ_0000729 Inhibits the Tumorigenesis of Non-Small Cell Lung Cancer Through Mediation of miR-1281/FOXO3 Axis

“…29,30 Activation of caspase 1 could lead to the upregulation of GSDME-N. 31,32 Meanwhile, IL-1β and IL-18 are also pyroptosis-related cytokines. 33,34 Consistently, our study revealed that knockdown of hsa_circ_0000729 could induce pyroptosis in NSCLC cells via upregulating cleaved caspase 1, GSDME-N, IL-1β and IL-18.…”

MDM2-Mediated Ubiquitination of RXRβ Contributes to Mitochondrial Damage and Related Inflammation in Atherosclerosis

“…PGC1α is a well-known master regulator of mitochondrial biogenesis. Furthermore, our previous study showed that PGC1α is one target gene of RXRβ in HAECs [ 14 ]. As shown in Figure 5 F, JNJ-165 increased the protein expression of PGC1α in ox-LDL treated endothelial cells, which was also abrogated by the transfection of RXRβ siRNA ( Figure 5 F).…”

“…Our previous studies have shown that MDM2 protein expression was upregulated, whereas RXRβ protein expression was downregulated in the aortas of LDLr -/- mice fed a high-fat diet [ 14 , 21 ]. This time we examined whether blockade of MDM2 activity by JNJ-165 could result in the prevention of atherosclerosis in atherosclerotic mice.…”

“…However, most studies focused on RXRα. Recently, our group has firstly reported that RXRβ exerted protective effects against the ox-LDL-induced inflammation in human aortic endothelial cells (HAECs) through regulating peroxisome proliferator-activated receptor γ coactivator-1α (PGC1α)-dependent mitochondrial homeostasis [ 14 ]. Our further study found that protein expression of RXRβ was downregulated in the aorta of high-fat diet-fed low-density lipoprotein receptor-deficient (LDLr -/- ) mice and ox-LDL-treated HAECs, but the mRNA level of RXRβ was not altered.…”

“…Our previous study also showed that MDM2 contributed to ox-LDL-induced inflammation through modulation of mitochondrial damage in endothelial cells [ 21 ]. Therefore, based on our previous studies [ 14 , 21 ], we were encouraged to investigate whether MDM2 acts as an E3 ligase to regulate the stabilization of RXRβ and further illustrate the function of MDM2 in atherosclerosis.…”