Overexpression of S-adenosylmethionine decarboxylase impacts polyamine homeostasis during development of Dictyostelium discoideum

Sharma, Priyanka; Kumar, Rishikesh; Saran, Shweta

doi:10.1387/ijdb.180167ss

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…In Dictyostelium, overexpression of SAMDC slowed cell proliferation, delayed development and arrested cells in S-phase of the cell cycle. Treatment with MGBG reduced cell proliferation and accelerated development but in samdc OE cells, it increased cell proliferation suggesting critical levels of spermidine to be important (Sharma et al, 2018). In conclusion, they showed that a narrow range of spermidine levels must be maintained for proper growth and development in Dictyostelium.…”

Section: Multicellular Development and Morphogenesismentioning

confidence: 92%

Glimpses of Dictyostelid research in India

Begum¹,

Saran²

2020

Int. J. Dev. Biol.

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Simple organisms are preferred for understanding the molecular and cellular function(s) of complex processes. Dictyostelium discoideum is a lower eukaryote, a protist and a cellular slime mould, which has been in recent times used for various studies such as cell differentiation, development, cell death, stress responses etc. It is a soil amoeba (unicellular) that undertakes a remarkable, facultative shift to multicellularity when exposed to starvation and requires signal pathways that result in alteration of gene expression and finally show cell differentiation. The amoebae aggregate, differentiate and form fruiting bodies with two terminally differentiated cells: the dead stalk (non-viable) and dormant spores (viable). In India, starting from the isolation of Dictyostelium species to morphogenesis, cell signalling and social evolution has been studied with many more new research additions. Advances in molecular genetics make Dictyostelium an attractive model system to study cell biology, biochemistry, signal transduction and many more.

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Section: Multicellular Development and Morphogenesismentioning

confidence: 92%

Glimpses of Dictyostelid research in India

Begum¹,

Saran²

2020

Int. J. Dev. Biol.

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“…[48] Many methods can be applied to prepare chemically crosslinked hydrogels such as chemical cross-linking, chemical and radiation grafting, radical polymerization, condensation reaction, enzyme reaction, and high-energy radiation. [49,50] Small molecular hydrogels, also known as supramolecular hydrogels, are composed of low molecular weight gelator with less than 2000 Daltons, including nucleic acid derivatives, amino acids, small peptides, carbohydrates, and so forth. Compared to polymer hydrogels, small molecular hydrogels have better biodegradability and biocompatibility, and because of the convenience of design and fabrication, they are attracting increasing attention in the field of drug delivery and cancer therapy.…”

Section:  Hydrogelmentioning

confidence: 99%

Gel/hydrogel‐based in situ biomaterial platforms for cancer postoperative treatment and recovery

et al. 2023

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Tumor surgical resection is the major strategy for cancer treatment. Meanwhile, perioperative treatment especially the postoperative adjuvant anticancer strategies play essential roles in satisfying therapeutic results and rapid recovery. Postoperative tumor recurrence, metastasis, bleeding, inter‐tissue adhesion, infection, and delayed wound healing are vital risks that could lead to poor prognosis or even treatment failure. Therefore, methods targeting these postoperative complications are in desperate need. In situ biomaterial‐based drug delivery platforms are promising candidates for postoperative treatment and recovery, resulting from their excellent properties including good biocompatibility, adaptive shape, limited systemic effect, designable function, and easy drug loading. In this review, we focus on introducing the gel/hydrogel‐based in situ biomaterial platforms involving their properties, advantages, and synthesis procedures. Based on the loaded contents in the gel/hydrogel such as anticancer drugs, immunologic agents, cell components, and multifunctional nanoparticles, we further discuss the applications of the in situ platforms for postoperative tumor recurrence and metastasis inhibition. Finally, other functions aiming at fast postoperative recovery were introduced, including hemostasis, antibacterial infection, adhesion prevention, tissue repair, and wound healing. In conclusion, gel/hydrogel is a developing and promising platform for postoperative treatment, exhibiting gratifying therapeutic effects and inconspicuous toxicity to normal tissues, which deserves further research and exploration.

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“…Many of these antiaging properties have been associated with spermidine's potency to exhibit proteostasis on the activation of cytoprotective macroautophagy [13,14]. A recent report showed that endogenous spermidine's genetic modulation affects growth and development in Dictyostelium discoideum [15]. Spermidine levels can be augmented in model organisms and humans when supplemented in food or water [8]; therefore, the impact of polyamines on aging is comparatively feasible to study.…”

Section: Clinical Medicine Hypothesismentioning

confidence: 99%

Spermidine Maintains Telomere Length and Delays Aging

Sharma

Jaiswal

2021

CAJMHE

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Spermidine, a natural polyamine, has been noticed for its anti-aging properties. Supplementation of this drug prolongs lifespan and diminishes the incidence of age-related pathology. In the human population, spermidine levels decrease as aging progresses, and a potential link between diminished endogenous spermidine levels and age-related declination has been studied. At the cellular level, autophagy is the prime mode of action of spermidine known to decline with the progress of aging, similarly contributing to the accretion of impaired macromolecules and organelles through aging. Epidemiological statistics support the concept, suggesting that elevated uptake of polyamine delays aging. Here, we overview the effect of autophagy on cellular processes and age-associated diseases, emphasizing the importance of these events to the hallmarks of aging. There are numerous factors like shortening telomere, oxidative stress, mitochondrial damage, and impaired intracellular calcium signaling, which are influenced by the aging process. We hypothesize that spermidine supplements in the diet increase the telomere length. The proposed hypothesis also brings to light the differentially regulated genes involved in telomere maintenance and aging after spermidine treatment. Knowing the role of spermidine in telomere maintenance would help us understand the molecular mechanism of spermidine's effect on aging.

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Overexpression of S-adenosylmethionine decarboxylase impacts polyamine homeostasis during development of Dictyostelium discoideum

Cited by 6 publications

References 12 publications

Glimpses of Dictyostelid research in India

Glimpses of Dictyostelid research in India

Gel/hydrogel‐based in situ biomaterial platforms for cancer postoperative treatment and recovery

Spermidine Maintains Telomere Length and Delays Aging

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