Overexpression of <scp>IFITM</scp>3 predicts poor prognosis in stage <scp>IIA</scp> esophageal squamous cell carcinoma after <scp>I</scp>vor <scp>L</scp>ewis esophagectomy

Jia, Yongsheng; Xiao, Zunqi; Jiang, Wenpeng; Chen, Gang; Wang, Zhou

doi:10.1111/1759-7714.12488

Cited by 20 publications

(13 citation statements)

References 28 publications

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“…The M5-T1 tumor was also specifically characterized by important changes in the content of several transmembrane proteins and components of the extracellular matrix. Among proteins belonging to the first category, IFM3 was reported to be highly expressed in invasive phenotypes of different types of cancer [ 61 , 62 ]. CSPG4, a cell surface proteoglycan, was overexpressed in a huge range of human and animal tumors, the tumor microenvironment, and cancer initiating cells [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma

et al. 2018

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Sarcomatoid mesothelioma (SM) is a devastating cancer associated with one of the poorest outcome. Therefore, representative preclinical models reproducing different tumor microenvironments (TME) observed in patients would open up new prospects for the identification of markers and evaluation of innovative therapies. Histological analyses of four original models of rat SM revealed their increasing infiltrative and metastatic potential were associated with differences in Ki67 index, blood-vessel density, and T-lymphocyte and macrophage infiltration. In comparison with the noninvasive tumor M5-T2, proteomic analysis demonstrated the three invasive tumors F4-T2, F5-T1 and M5-T1 shared in common a very significant increase in the abundance of the multifunctional proteins galectin-3, prohibitin and annexin A5, and a decrease in proteins involved in cell adhesion, tumor suppression, or epithelial differentiation. The increased metastatic potential of the F5-T1 tumor, relative to F4-T2, was associated with an increased macrophage vs T-cell infiltrate, changes in the levels of expression of a panel of cytokine genes, an increased content of proteins involved in chromatin organization, ribosome structure, splicing, or presenting anti-adhesive properties, and a decreased content of proteins involved in protection against oxidative stress, normoxia and intracellular trafficking. The most invasive tumor, M5-T1, was characterized by a pattern of specific phenotypic and molecular features affecting the presentation of MHC class I-mediated antigens and immune cell infiltration, or involved in the reorganization of the cytoskeleton and composition of the extracellular matrix. These four preclinical models and data represent a new resource available to the cancer research community to catalyze further investigations on invasiveness.

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Section: Discussionmentioning

confidence: 99%

Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma

et al. 2018

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“…In contrast to other digestive tract components, the esophagus has its own unique histological structure involving rich lymphatic drainage and anastomosis in the submucosa, which may lead to early lymph node metastasis and postoperative LMR. [28][29][30] In 1991, Yoshinaka et al reported that approximately 47% of ESCC patients experienced lymphatic metastasis when the submucosa (T1b) was invaded. 31 Evidence indicates that postoperative adjuvant chemotherapy could significantly improve the five-year survival rate in advanced tumors, but adjuvant chemotherapy has not been demonstrated to be advantageous in early stage ESCC because of significant adverse effects.…”

Section: Discussionmentioning

confidence: 99%

FOXM1: A potential indicator to predict lymphatic metastatic recurrence in stage IIA esophageal squamous cell carcinoma

et al. 2018

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BackgroundPrevious studies have elucidated that FOXM1 may predict poor prognosis in patients with multiple solid malignant tumors. In this study we explored the differential expression of FOXM1 in stage IIA esophageal squamous cell carcinoma (ESCC) and investigated its prognostic value.MethodsImmunohistochemistry (IHC) and Western blot were used to detect FOXM1 expression in ESCC. Correlations between FOXM1 expression and clinicopathological variables, and five‐year lymphatic metastatic recurrence (LMR) and overall survival (OS) of patients were analyzed.ResultsFOXM1 was aberrantly expressed in ESCC. Statistical analysis revealed a close relationship between FOXM1 expression and tumor size (P = 0.024), depth of invasion (P = 0.048), and degree of differentiation (P = 0.043). The five‐year LMR of patients in the FOXM1 overexpression group was significantly increased compared to the low expression group (P = 0.001). The five‐year OS of patients in the FOXM1 overexpression group was significantly reduced compared to the low expression group (P = 0.007). Log‐rank tests demonstrated that large tumor size (P = 0.044), poor differentiation degree (P = 0.005), deep invasion (P = 0.000), and FOXM1 overexpression (P = 0.007) may indicate poor prognosis in stage IIA ESCC. Cox multivariate regression analysis revealed that all of these variables were independent predictors of unfavorable outcome (P < 0.05).ConclusionFOXM1 could be a predictor of lymphatic metastatic recurrence in stage IIA ESCC after Ivor Lewis esophagectomy.

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“…79 More recently, 5-year survival rates for stage IIA ESCC patients with high IFITM3 expression were reported to be 78.7%, versus 64.9% in those with low IFITM3 expression. 80 Thus, IFITM3 has less of an influence on 5-year survival rates in stage IIA ESCC patients than in pN0 patients, suggesting it could only be a predictor for LNM in pN0 ESCC. Knockdown of IFITM3 expression significantly suppressed gastric cancer cell migration, invasion, and proliferation in vitro , arrested cells at the G0/G1 phase, and reduced numbers in S phase of the cell cycle.…”

Section: Ifitm3mentioning

confidence: 91%

Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review

Zhan

et al. 2019

J Int Med Res

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Esophageal cancer is the eighth most common form of cancer worldwide, and esophageal squamous cell carcinoma (ESCC) is a major type of esophageal cancer that arises from epithelial cells of the esophagus. Local lymph node metastasis (LNM) is a typical sign of failure for ESCC clinical treatments, and a link has been established between LNM and the aberrant expression of specific biomarkers. In this review, we summarize what is known about nine factors significantly associated with LNM in ESCC patients: phosphatase and tensin homolog (PTEN), mucin 1, vascular endothelial growth factor-C, tumor necrosis factor alpha-induced protein 8 (TNFAIP8), Raf-1 kinase inhibitory protein, stathmin (STMN1), metastasis-associated protein 1, caveolin-1, and interferon-induced transmembrane protein 3. The function of these nine proteins involves four major mechanisms: tumor cell proliferation, tumor cell migration and invasion, epithelium–mesenchymal transition, and chemosensitivity. The roles of PTEN, STMN1, and TNFAIP8 involve at least two of these mechanisms, and we suggest that they are possible biomarkers for predicting LNM in ESCC. However, further retrospective research into PTEN, STMN1, and TNFAIP8 is needed to test their possibilities as indicators.

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Overexpression of IFITM3 predicts poor prognosis in stage IIA esophageal squamous cell carcinoma after Ivor Lewis esophagectomy

Cited by 20 publications

References 28 publications

Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma

Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma

FOXM1: A potential indicator to predict lymphatic metastatic recurrence in stage IIA esophageal squamous cell carcinoma

Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review

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