2008
DOI: 10.1158/1078-0432.ccr-07-4717
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Overexpression of Stromal Cell–Derived Factor 1 and Its Receptor CXCR4 Induces Autocrine/Paracrine Cell Proliferation in Human Pituitary Adenomas

Abstract: Purpose: Hypothalamic or locally produced growth factors and cytokines control pituitary development, functioning, and cell division. We evaluated the expression of the chemokine stromal cell^derived factor 1 (SDF1) and its receptor CXCR4 in human pituitary adenomas and normal pituitary tissues and their role in cell proliferation. Experimental Design: The expression of SDF1 and CXCR4 in 65 human pituitary adenomas and 4 human normal pituitaries was determined by reverse transcription-PCR, immunohistochemistry… Show more

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Cited by 91 publications
(112 citation statements)
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“…The latter finding is consistent with results from a previous study that indicated that anti-CXCR4 treatment suppressed primary brain tumor growth and that treatment of mice with AMD3100 resulted in decreased proliferation and invasion of the xenografted brain tumors as well as in better survival of the animals (Rubin et al 2003). In addition, the activation of CXCR4 has been shown to stimulate cell proliferation in human pituitary adenoma cultures (Barbieri et al 2008). In the present study, we showed that the Cxcr4 pathway is involved in pituitary tumor growth in vivo.…”
supporting
confidence: 92%
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“…The latter finding is consistent with results from a previous study that indicated that anti-CXCR4 treatment suppressed primary brain tumor growth and that treatment of mice with AMD3100 resulted in decreased proliferation and invasion of the xenografted brain tumors as well as in better survival of the animals (Rubin et al 2003). In addition, the activation of CXCR4 has been shown to stimulate cell proliferation in human pituitary adenoma cultures (Barbieri et al 2008). In the present study, we showed that the Cxcr4 pathway is involved in pituitary tumor growth in vivo.…”
supporting
confidence: 92%
“…In the present study, we showed that the Cxcr4 pathway is involved in pituitary tumor growth in vivo. AMD3100 was found to induce AtT20 cell death and apoptosis and to reduce cell proliferation (as analyzed in vitro), which is similar to findings by others for pituitary and other tumors (Barbieri et al 2008, Gatti et al 2013. Whether EMT is (also) implicated in the growth-inhibitory effect of AMD3100 is not yet clear; the expression of the tested selection of EMT genes was not affected after long-term treatment in vivo (20 days) or short-term exposure in vitro (72 h).…”
supporting
confidence: 89%
“…CXCR4 and SDF-1 are overexpressed in human pituitary adenomas, and as CXCR4 activation may contribute to pituitary cell proliferation, and, possibly, adenoma development as well, AMD3100 could play a role in suppressing the growth of pituitary adenomas in humans [45]. AMD3100 has also been reported to decrease invasion of human colorectal cancer cells in vitro [46].…”
Section: Page 8 Of 30mentioning
confidence: 99%
“…Previous studies regarding this subject have been extensively reviewed before (Florio 2011;Lloyd et al 2013;Vankelecom and Gremeaux 2010;Vankelecom 2012;Vankelecom and Chen 2014). Some candidate TSC were proposed, for instance, based on spheroid formation (Xu et al 2009) and marker expression (Barbieri et al 2008), but convincing evidence was not provided and some results remained questionable (discussed in Vankelecom and Gremeaux 2010;Vankelecom 2012;Vankelecom and Chen 2014).…”
Section: Pituitary Tumorigenesismentioning
confidence: 99%