Overexpression of Survivin and XIAP in MDR cancer cells unrelated to P-glycoprotein

Shi, Zhi; Liang, Yong; Chen, Zhe‐Sheng; Wang, Xiaohong; Ding, Yan; Chen, Li Ming; Li, Fu

doi:10.3892/or.17.4.969

Cited by 32 publications

(38 citation statements)

References 33 publications

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“…Although a previous study showed different results (39), the present study demonstrated that survivin and P-gp played important roles in multidrug resistance in breast cancer MCF-7 cells. The expression and transcription of survivin were regulated by P-gp to result in drug resistance.…”

Section: Discussionmentioning

confidence: 57%

Survivin transcription is associated with P-glycoprotein/MDR1 overexpression in the multidrug resistance of MCF-7 breast cancer cells

Jiang¹

2010

Oncol Rep

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Abstract. Breast carcinoma is the most common malignancy in women. The progression of tumor is associated with overexpression of inhibitors of apoptosis proteins (IAPs) such as survivin and multidrug resistant P-glycoprotein (P-gp). PI3K/Akt pathway is involved in cell cycle progression, apoptosis and neoplastic transformation. PI3K/Akt has been shown to regulate survivin in breast cancer. The aim of this study was to investigate the expression of survivin and P-gp, the modulation of survivin by P-gp in PI3K/Akt during the progression of drug resistance (MDR) in MCF-7 breast cancer cells and adriamycin (ADR)-resistant MCF-7/ADR cells. The expression of survivin and P-gp in MCF-7/ADR cells were higher than that of the MCF-7 cells using RT-PCR and Western blot analysis. Survivin transcription was associated with P-glycoprotein/MDR1 overexpression using promoter activity analysis. LY294002, specific inhibitor of PI3K could suppress survivin and P-gp expression, decreased survivin promoter activity and enhanced cell sensitivity to drugs. This study shows survivin transcription was associated with P-glycoprotein/MDR1 overexpression, PI3k/Akt pathway was involved in P-glycoprotein/MDR1 associated survivin transcription activity in the multidrug resistant MCF-7 breast cancer cells.

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Section: Discussionmentioning

confidence: 57%

Survivin transcription is associated with P-glycoprotein/MDR1 overexpression in the multidrug resistance of MCF-7 breast cancer cells

Jiang¹

2010

Oncol Rep

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“…Further, we confirmed these results from a DNA microarray by western blot analysis. Moreover, our cell cycle analysis shows that GP induces cell cycle arrest at the G0/G1 phase in prostate is an inhibitor of apoptosis protein (IAP), which is overexpressed in human cancer cells and plays an important role in apoptosis [41][42][43][44]. Thus, the inhibition of proliferation of prostate cancer cells by GP is mediated by the expression of genes involved in the cell cycle and survival.…”

Section: Discussionmentioning

confidence: 91%

Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling

Jiang

Slivova

Jedinak

et al. 2011

Clin Exp Metastasis

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Although previous studies demonstrated anticancer activities of gossypol through the induction of apoptosis, the molecular mechanism(s) responsible for the inhibitory effects of gossypol on the metastatic behavior of cancer cells remain to be elucidated. Here, we show that gossypol inhibits growth of human prostate cancer cells through the modulation of cell cycle regulatory proteins. We also demonstrate that gossypol inhibits invasive behaviors (adhesion, migration, and invasion) and angiogenesis. These effects are mediated by the suppression of AP-1 and NF-κB activity, resulting in the inhibition of secretion of urokinase plasminogen activator and vascular endothelial growth factor, and the down-regulation of expression of chemokine receptor 4 in PC3 cells. In summary, our data suggest that gossypol could have potential therapeutic effect for the treatment of invasive prostate cancer.

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“…According to the recent literature, survivin overexpression appears to correlate with poorer prognosis in LSCC [20,21]. Currently, the relationship between survivin and P-gp expression in malignancies is still controversial [22,23].…”

Section: Introductionmentioning

confidence: 99%

Effect of apoptotic and proliferative indices, P-glycoprotein and survivin expression on prognosis in laryngeal squamous cell carcinoma

Gao

Shen

et al. 2010

Med Oncol

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This study was to explore the relationship between P-glycoprotein and survivin expression with apoptotic index, proliferative index, clinicopathologic characteristics, and their prognostic value in laryngeal squamous cell carcinoma (LSCC). Samples from 86 patients with LSCC were analyzed for P-glycoprotein, survivin, and Ki-67 expression by immunohistochemistry and apoptotic index by the TUNEL method. The association of P-glycoprotein and survivin expression with clinicopathologic parameters, apoptotic and proliferative activities, and patients' overall survival was subsequently analyzed. We found that up-regulation of P-glycoprotein expression was associated with decreased apoptosis but not with changes in proliferation, whereas increased survivin expression was correlated with decreased apoptosis and increased proliferation. There was a positive correlation between P-glycoprotein and survivin expression. Expression of these two proteins was significantly related to the clinical stage, histological grade, lymph node metastasis, and overall survival in LSCC. These results reveal that survivin and P-glycoprotein may have an effect on chemotherapy resistance and progression of LSCC through promoting proliferation and/or suppressing apoptosis. Furthermore, our results demonstrate that P-glycoprotein and survivin proteins are both predictive of malignant progression and prognosis of LSCC.

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Overexpression of Survivin and XIAP in MDR cancer cells unrelated to P-glycoprotein

Cited by 32 publications

References 33 publications

Survivin transcription is associated with P-glycoprotein/MDR1 overexpression in the multidrug resistance of MCF-7 breast cancer cells

Survivin transcription is associated with P-glycoprotein/MDR1 overexpression in the multidrug resistance of MCF-7 breast cancer cells

Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling

Effect of apoptotic and proliferative indices, P-glycoprotein and survivin expression on prognosis in laryngeal squamous cell carcinoma

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