Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect

Kamohara, Ryotaro; Yamaza, Haruyoshi; Tsuchiya, Tomoshi; Komatsu, Toshimitsu; Park, Seong Joon; Hayashi, Hiroko; Chiba, Takuya; Mori, Ryoichi; Otabe, Shuichi; Yamada, Kentaro; Nagayasu, Takeshi; Shimokawa, Isao

doi:10.1016/j.exger.2015.02.011

Cited by 3 publications

(2 citation statements)

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“…Stress resistance is one of the hallmarks in CR animals, although whether this trait directly causes the extension of lifespan remains unclear. We tested stress resistance in Foxo1 +/− mice using the endotoxin shock model following the procedures of Kamohara [52]. The survival rates and endoplasmic reticulum (ER) stress were monitored after lipopolysaccharide (LPS) injection.…”

Section: Pleiotropic Roles For Foxo1 In Disordersmentioning

confidence: 99%

“…The survival rates and endoplasmic reticulum (ER) stress were monitored after lipopolysaccharide (LPS) injection. ER stress-responsive alkaline phosphatase (ESTRAP) mice [53] were used to monitor ER stress in vivo (details are described elsewhere [52]). In ESTRAP mice, secreted alkaline phosphatase (SEAP) is constitutively expressed, and SEAP activity in the blood is reduced by ER stress [53].…”

Section: Pleiotropic Roles For Foxo1 In Disordersmentioning

confidence: 99%

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Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

et al. 2019

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This review focuses on mechanisms of calorie restriction (CR), particularly the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis as an evolutionary conserved signal that regulates aging and lifespan, underlying the effects of CR in mammals. Topics include (1) the relation of the GH-IGF-1 signal with chronic low-level inflammation as one of the possible causative factors of aging, that is, inflammaging, (2) the isoform specificity of the forkhead box protein O (FoxO) transcription factors in CR-mediated regulation of cancer and lifespan, (3) the role for FoxO1 in the tumor-inhibiting effect of CR, (4) pleiotropic roles for FoxO1 in the regulation of disorders, and (5) sirtuin (Sirt) as a molecule upstream of FoxO. From the evolutionary view, the necessity of neuropeptide Y (Npy) for the effects of CR and the pleiotropic roles for Npy in life stages are also emphasized. Genes for mediating the effects of CR and regulating aging are context-dependent, particularly depending on nutritional states.

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Section: Pleiotropic Roles For Foxo1 In Disordersmentioning

confidence: 99%