Overexpression of the UDP-glycosyltransferase UGT34A23 confers resistance to the diamide insecticide chlorantraniliprole in the tomato leafminer, Tuta absoluta

UDP-Glycosyltransferases UGT350C3 and UGT344L7 Confer Tolerance to Neonicotinoids in Field Populations of Aphis gossypii

“…litura in Drosophila reduced the indoxacarb toxicity to flies . Ectopic expression of UGT34A23 from Tuta absoluta in Drosophila indicated that overexpression of this gene in flies conferred strong and significant tolerance to chlorantraniliprole in vivo . In this study, UGT350C3 and UGT344L7 of A.…”

“…25 Ectopic expression of UGT34A23 from Tuta absoluta in Drosophila indicated that overexpression of this gene in flies conferred strong and significant tolerance to chlorantraniliprole in vivo. 47 In this study, UGT350C3 and UGT344L7 of A. gossypii were ectopically expressed in Drosophila to assess their tolerance to neonicotinoids. The Drosophila bioassay results indicated that the overexpressing UGT350C3 and UGT344L7 lines exhibited significant tolerance to thiamethoxam, imidacloprid, and dinotefuran, suggesting that these two UGTs contributed to neonicotinoid tolerance in cotton aphid (Figure 5, Table S5).…”

Molecular characterization and expression patterns of a ryanodine receptor in soybean looper, Chrysodeixis includens

“…Other mutation sites, such as E1338D and Q4594L, were identified in Plutella xylostella (Guo et al, 2014), and Y4667D/C (corresponding to Y4701 in P. xylostella) and Y4891F (corresponding to Y4922 in P. xylostella) were detected in Chilo suppressalis (Huang et al, 2020). Additionally, metabolic resistance appears to also play a significant role, mediated by notable overexpression of detoxification enzymes found in certain insects, including C. suppressalis (Zhao et al, 2019), P. xylostella (Li et al, 2017), Tuta absoluta (Grant et al, 2023), and others (see Nauen & Steinbach, 2016 for a comprehensive review).…”

Overexpression and nonsynonymous mutations of UDP-glycosyltransferases are potentially associated with pyrethroid resistance in Anopheles funestus

“…These activities have been observed in economically important species such as the silkworm Bombyx mori [ 33 ], the tobacco hornworms Manduca sexta [ 34 ] and the Asian corn borer Ostrinia furnacalis [ [35] , [36] , [37] ] UGT-mediated biotransformation of pyrethroids has been suggested in Anopheles sinensis, a common malaria vector in Southeast Asia [ 38 ]. Their contribution to resistance against several classes of insecticide has been reported in the Diamondback moth Plutella xylostella and the tomato leafminer Tuta absoluta resistance to chlorantraniliprole [ 39 , 40 ], the housefly Musca domestica resistance to organophosphate [ 41 ], and the greenfly cotton aphid Aphis gossypii resistance to neonicotinoid and spirotetramat [ 42 , 43 ].…”