2016
DOI: 10.1017/pao.2016.14
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Overexpression of Trypanosoma rangeli trypanothione reductase increases parasite survival under oxidative stress

Abstract: S U M M A R YThe infectivity and virulence of pathogenic trypanosomatids are directly associated with the efficacy of their antioxidant system. Among the molecules involved in the trypanosomatid response to reactive oxygen or nitrogen species, trypanothione reductase (TRed) is a key enzyme. In this study, we performed a molecular and functional characterization of the TRed enzyme from Trypanosoma rangeli (TrTRed), an avirulent trypanosome of mammals. The TrTRed gene has an open reading frame (ORF) of 1473 bp (… Show more

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