Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma

Abstract

In China, hepatocellular carcinoma (HCC) is the most commonly diagnosed cancer and the leading cause of cancer death in men, followed by lung and stomach cancer. There was an urgent need to identify novel prognostic biomarkers for HCC. We explored the expression pattern of m6A related proteins in HCC tissues by using TCGA in this study. We found that the m6A 'reader' YTHDF1 was significantly upregulated in HCC and was positive correlated with pathology stage. Kaplan-Meier analysis showed that Lower YTHDF1 expression level was associated with better survival of HCC patients. Furthermore, we performed GO and KEGG pathway analysis of YTHDF1 co-expressed genes and found YTHDF1 played an important role in regulating HCC cell cycle progression and metabolism. We believed that this study will provide a potential new therapeutic and prognostic target for HCC.

Diagnostic, progressive and prognostic performance of m6A methylation RNA regulators in lung adenocarcinoma

“…From the results of Figure S1, in the training and validation cohorts, YTHDF1 had a good diagnostic performance. So far, many studies in progress with regard toYTHDF1 in colorectal carcinoma and hepatocellular carcinoma, which was usually regarded as an independent prognostic factor [56][57][58]. However, there has been no related reports on LUAD, and no has been conducted as a diagnostic factor.…”

RNA N6-Methyladenosine-Related Gene Contribute to Clinical Prognostic Impact on Patients With Liver Cancer

“…Recent studies showed that tumor mutation burden (TMB) is also significantly associated with the susceptibility to anti-tumor immunotherapy, and a higher TMB indicates better prognosis in many cancer types (Peng et al, 2019;Wang and Li, 2019). The m6A-related gene YTHDF1 was also closely related to the prognosis of HCC in the TCGA dataset in a previous study (Zhao et al, 2018). We compared the AUC values of our established nomogram with these biomarkers, and found that the predictive power of the nomogram was superior for 1-, 2-, and 3-year OS in the LIRI-JP dataset (Figure 6).…”

Different DNA methylation profile is demonstrated in paracoccidioidomycosis patients without oral lesions

“…Among its physiological roles, YTHDF1 enables translation of m 6 A‐methylated neuronal mRNAs in reaction to neuronal stimulus, which aids to learning and memory . On the other hand, protein expression of YTHDF1 is upregulated in hepatocellular carcinoma (HCC), being associated with tumour cell cycle, base excision repair, DNA replication, RNA splicing and RNA degradation . Lower YTHDF1 expression has been shown better survival of HCC patients .…”

“…On the other hand, protein expression of YTHDF1 is upregulated in hepatocellular carcinoma (HCC), being associated with tumour cell cycle, base excision repair, DNA replication, RNA splicing and RNA degradation . Lower YTHDF1 expression has been shown better survival of HCC patients . YTHDF1 inhibition has reduced translation efficacy of its target transcripts, indicating an efficient role of YTHDF1 in mRNA translation .…”

“…43 On the other hand, protein expression of YTHDF1 is upregulated in hepatocellular carcinoma (HCC), being associated with tumour cell cycle, base excision repair, DNA replication, RNA splicing and RNA degradation. 44,45 The patterns of DNA methylation are altered in response to changes in diet and also to environmental exposure. The methyl groups are derived from the diet and donated to the DNA through the pathway of folate and methionine, and the absence of methyl can cause profound changes in the cellular balance and lead to serious consequences such as establishment of pathologies.…”