Overlap connective tissue disease, pulmonary fibrosis, and extensive subcutaneous calcification

Chan, Aw

doi:10.1136/ard.62.7.690

Cited by 8 publications

(5 citation statements)

References 5 publications

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“…Overlap connective tissue disease (CTD) occurs when the classification criteria for two or more ACTDs are met in the same patient. Overlap CTD is uncommonly associated with calcinosis cutis (20). In two patients reported by Chan et al (20) and six patients reported by Balin et al (5) with overlap CTD-associated calcinosis cutis, the lesions were localized to the extremities, hands, or feet and had a variable incubation from diagnosis of the primary disease.…”

Section: Overlap Undifferentiated and Mixed Connective Tissue Diseasementioning

confidence: 93%

“…Overlap CTD is uncommonly associated with calcinosis cutis (20). In two patients reported by Chan et al (20) and six patients reported by Balin et al (5) with overlap CTD-associated calcinosis cutis, the lesions were localized to the extremities, hands, or feet and had a variable incubation from diagnosis of the primary disease. Undifferentiated CTDs are a heterogeneous group with varying clinical and serologic features that have not yet reached classification criteria for a single ACTD.…”

Section: Overlap Undifferentiated and Mixed Connective Tissue Diseasementioning

confidence: 93%

“…Overlap CTD is uncommonly associated with calcinosis cutis (20). Overlap CTD is uncommonly associated with calcinosis cutis (20).…”

Section: Overlap Undifferentiated and Mixed Connective Tissue Diseasementioning

confidence: 99%

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Calcinosis cutis in autoimmune connective tissue diseases

2012

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Calcinosis cutis is a chronic condition involving insoluble calcified deposits of the skin and subcutaneous tissue. It is commonly associated with autoimmune connective tissue diseases and can be a source of pain and functional disability. The likelihood of developing calcinosis varies among the autoimmune connective tissue diseases, with systemic sclerosis and dermatomyositis being the most commonly associated. Identification of therapy for this challenging disorder has been hampered by a paucity of large controlled trials. Although there is no uniformly effective treatment for calcinosis cutis, several surgical and medical therapies have demonstrated varying degrees of benefit in the treatment of calcinosis, including surgical excision, laser therapy, extracorporeal shock wave lithotripsy, diltiazem, minocycline, colchicine, and topical sodium thiosulfate, along with others. Recommendations for the diagnosis and therapy of calcinosis cutis in patients with autoimmune connective tissue diseases are discussed.

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Section: Overlap Undifferentiated and Mixed Connective Tissue Diseasementioning

confidence: 93%

Section: Overlap Undifferentiated and Mixed Connective Tissue Diseasementioning

confidence: 93%

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Calcinosis cutis in autoimmune connective tissue diseases

2012

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“…This report predates the widespread recognition of IBM and could possibly be similar to our case. Subcutaneous calcification is described in dermatomyositis, but not in sIBM 9. There have been reports of an IBM/dermatomyositis overlap syndrome based mainly on muscle biopsy appearances suggesting the former, with a skin rash suggesting the latter, but none had subcutaneous calcification 10.…”

Section: Discussionmentioning

confidence: 98%

Oculopharyngeal myopathy with inflammation and calcinosis: an unusual phenotype

Jenkins

Al‐Sarraj

Rose

2007

Journal of Neurology, Neurosurgery & Psychiatry

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The case is reported of a patient with progressive proximal and distal weakness, dysphagia, respiratory weakness, calcifications, ptosis and ophthalmoparesis with inflammation, rimmed vacuoles and positive amyloid and ubiquitin on muscle biopsy. The histopathological features fit best with inclusion body myositis, but ophthalmoparesis and ptosis have not previously been described. The clinical phenotype fits best with hereditary inclusion body myopathy or distal-oculopharyngeal muscular dystrophy, but the degree of inflammation seen is unusual. None of these are associated with calcinosis.

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“…Considering overlap syndromes, calcinosis is uncommon and located on the extremities, hands, and feet [ 50 , 101 ]. UCTD is also rarely complicated by calcinosis formation after a mean time interval of 2.7 years from the primary diagnosis, mainly on the extremities, hands, and feet [ 102 , 103 ].…”

Section: Discussionmentioning

confidence: 99%

Calcinosis Prevalence in Autoimmune Connective Tissue Diseases—A Retrospective Study

Róbert,

Németh,

Marschalkó

et al. 2024

JCM

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Background/Objectives: Calcinosis cutis is the deposition of insoluble calcium salts, which may cause inflammation, ulceration, pain, and restricted joint mobility. It rarely develops in damaged tissues (dystrophic subtype), most frequently in autoimmune connective tissue diseases (CTDs), but there is very limited data on the prevalence. Also, therapy remains an unsolved issue. In this study, we aimed to collect data on the prevalence of calcinosis in CTD patients to highlight that it is a considerable problem. Methods: A retrospective study was conducted in our department to assess the epidemiology of dystrophic calcinosis in CTDs between January 2003 and January 2024. Results: A total of 839 CTD patients were identified, of whom 56 had calcinosis (6.67%). The mean age of the calcinosis patients at diagnosis of underlying CTD was 41.16 ± 19.47 years. The mean time interval from the onset of calcinosis was 5.96 ± 8.62 years. Systemic sclerosis was the most common CTD complicated by calcinosis (n = 22). Conclusions: Our results are comparable to those reported previously in the literature. Although calcinosis is rare in the overall population, it is a present and unsolved problem in CTD patients. Therefore, further studies are needed on the factors involved in the development and progression of calcinosis as well as its treatment.

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Overlap connective tissue disease, pulmonary fibrosis, and extensive subcutaneous calcification

Abstract: Swollen joint count 9.9 (6.8) 5.8 (7.5)* 2.3 (4.6)* PASI (psoriasis activity skin index) 12.1 (10.3) 1.7 (5.6)* 1.1 (2.7)* ESR (mm/1st h) 21.6 (15.5) 15.9 (9.4) 20.2 (20.4) CRP (mg/l) 0.9 (0.9) 0.7 (1.3) 0.2 (0.4)* *p<0.01 as compared with baseline (determined by t test for paired data).

Cited by 8 publications

References 5 publications

Calcinosis cutis in autoimmune connective tissue diseases

Calcinosis cutis in autoimmune connective tissue diseases

Oculopharyngeal myopathy with inflammation and calcinosis: an unusual phenotype

Calcinosis Prevalence in Autoimmune Connective Tissue Diseases—A Retrospective Study

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