Overlap of GERD and gastrointestinal functional disorders

Bortoli, Nicola de; Natali,; Melissari, Sara; Simonetti, N.; Tapete, G.; Marchi, Santino

doi:10.23736/s1121-421x.17.02398-4

Cited by 7 publications

(6 citation statements)

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“…GERD occurred overall in 30% of all study patients, which correlates with the reported range of the well-known GERD-IBS overlap between 10 and 74% based on endoscopic diagnosis [ 43 , 44 ]. Different mechanisms, such as visceral hypersensitivity or dysmotility with delayed gastric emptying in affected patients, smooth muscle dysfunction of the GI tract, or impaired duodenal acid clearance, have been considered [ 45 , 46 , 47 , 48 , 49 , 50 ].…”

Section: Discussionsupporting

confidence: 76%

Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse Population

Lee,

Rao,

Cabral

et al. 2024

JCM

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Introduction: Irritable bowel syndrome (IBS) is a disorder of gut–brain interaction (DGBI), and associated co-morbidities worsen quality of life. Research concerning IBS co-morbidities in different racial/ethnic groups is very sparse. This study aimed to determine the prevalence rates of co-morbidities and possible differences in a multiracial/ethnic IBS cohort. Methods: Based on ICD-9-coded IBS diagnosis, 740 outpatients (≥18 years) were included in this retrospective study at Boston Medical Center. Demographics and ICD-9-coded co-morbidities were extracted from electronic records. Descriptive statistics and multiple logistic regression were used for data analyses. Results: The most prevalent co-morbidities in this IBS cohort included gastroesophageal reflux disorder (GERD) (30%), depression (27%), anxiety (23%), (chronic obstructive pulmonary disease) COPD/asthma (16%), and obesity (10%). GERD was more prevalent in Hispanics and Blacks (p = 0.0005), and non-ulcer dyspepsia (NUD) was more prevalent in Blacks and Asians (p = 0.003). Higher rates of diabetes mellitus type 2 (DMT2) (p = 0.0003) and depression (p = 0.03), but not anxiety (p = 0.9), were present in Blacks and Hispanics. GERD was significantly associated with Hispanics (p = 0.003), dependent on age, overweight, and obesity. NUD was significantly associated with Blacks (p = 0.01) and Asians (p = 0.006), independent of sex, age, and BMI. Cancer of the thyroid, ovaries, and testis occurred at a five-fold higher rate than expected. Conclusions: Significant racial/ethnic differences exist for IBS co-morbidities in this study cohort, including depression, DMT2, GERD, and NUD. Certain cancers were found to be more frequent in this IBS sample as compared with the general population.

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Section: Discussionsupporting

confidence: 76%

Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse Population

Lee,

Rao,

Cabral

et al. 2024

JCM

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“…Minerva Medica, 2017, pagg. [1][2][3][4][5][6][7] The definitive version is available at: La versione definitiva è disponibile alla URL: [https://www.minervamedica.it/it/riviste/minerva-medica/index.php] Dyspepsia is a common disorder characterized by upper abdominal discomfort or pain and meal-related symptoms, with a notable impact on quality of life and sense of well-being of affected subjects. 1 In the clinical context, a key issue is the accurate identification of patients with dyspepsia who require further investigation to rule out serious underlying structural diseases.…”

Section: This Is An Author Version Of the Contribution Published Onmentioning

confidence: 99%

“…2 Despite a certain degree of overlapping features, according to Rome IV criteria, functional dyspepsia (FD) is defined as the predominant presence of one or more symptoms including bothersome postprandial fullness or early satiation (post-prandial distress syndrome), epigastric pain (epigastric pain syndrome) or epigastric burning, occurring for the last 3 months with the onset occurring at least 6 months prior to diagnosis, in absence of evident structural disease. 3,4 While the global prevalence of FD is estimated to be 10-30% worldwide, 3 in Italy, in the general population, it reaches to 11% with unemployment, divorce and smoking, but not Helicobacter pylori (H. pylori) infection, being the main cause associated with an increased risk. 5 The pathogenesis of FD is likely multifactorial and still unclear; however, impaired gastrointestinal motility with delayed gastric emptying, impaired gastric accommodation after ingestion of a meal, and gastric and duodenal hypersensitivity to distension and intraluminal contents, seem to play a role in a substantial group of patients.…”

Section: This Is An Author Version Of the Contribution Published Onmentioning

confidence: 99%

Gastric emptying and related symptoms in patients treated with buspirone, amitriptyline or clebopride: a "real world" study by 13C-octanoic Acid Breath Test

et al. 2017

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BACKGROUND: Gastric motility is a key-factor in the pathogenesis of functional dyspepsia (FD). 13C-octanoic acid breath test (OBT) is a tool used for measuring gastric emptying time in clinical setting. We aimed to investigate the variation in FD symptoms and OBT parameters before and after treatment with buspirone, amitriptyline or clebopride. METHODS:Between Jan-2007 and Dec-2014, we enrolled 59 patients with FD unresponsive to firstline therapy with proton pump inhibitors and/or domperidone that underwent OBT before and after 3 months of buspirone (n=32), amitriptyline (n=16) or clebopride (n=11) treatment. RESULTS:Early satiation severity was positively correlated with gastric half emptying time (t1/2) (r=0.3789, p=0.003) and gastric lag phase (r=0.3371, p=0.011), and negatively correlated with gastric emptying coefficient (r=-0.3231, p=0.015). A reduction in t1/2 measurement in association to postprandial fullness, and early satiation severity improvement was observed (p=0.009, p=0.005 and p<0.001, respectively). Patients treated with buspirone obtained both a decrease in t1/2 (p=0.005) and an amelioration in early satiation (p=0.001). Patients under amitriptyline treatment experienced an improvement in post-prandial fullness (p=0.046), whereas no variation was reported in patients treated with clebopride. CONCLUSIONS:Patients with FD, non-responders to first-line therapy and reporting meal-related discomfort, may benefit from buspirone or amitriptyline-based therapies.

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“…Nonanginal chest pain is referred by affected patients due to abnormal oesophageal acid exposure, because of the reflux events. 20 Although the pathophysiology of GERD remains unclear, it is accepted as a multifactorial disease with alterations in the normal gastrointestinal tract anatomy and diseases that affect the lower oesophageal sphincter, oesophageal clearance, stomach motility and gastric emptying, and it might lay a foundation for GERD development. 21 The multifactorial pathogenesis involves transient lower oesophageal sphincter relaxations as well as other lower oesophageal sphincter pressure abnormalities.…”

Section: Introductionmentioning

confidence: 99%

“…GERD occurs when the reflux of gastric contents in the oesophagus leads to troublesome symptoms, with or without mucosal involvement. Non‐anginal chest pain is referred by affected patients due to abnormal oesophageal acid exposure, because of the reflux events 20 . Although the pathophysiology of GERD remains unclear, it is accepted as a multifactorial disease with alterations in the normal gastrointestinal tract anatomy and diseases that affect the lower oesophageal sphincter, oesophageal clearance, stomach motility and gastric emptying, and it might lay a foundation for GERD development 21 .…”

Section: Introductionmentioning

confidence: 99%

Chest pain and palpitations in postmenopausal women with mitral valve prolapse: is there a gastro‐oesophageal origin?

Maiello

Zito

Cecere

et al. 2022

Internal Medicine Journal

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Background and aim Mitral valve prolapse (MVP) is a common disease in women, causing chest pain and palpitation due to structural and functional valve abnormality, and is sometimes associated with gastro‐oesophageal reflux disease (GERD). This is a challenging clinical problem in clinical practice and requires targeted diagnostic assessment to identify the underlying causes of the symptoms, because treatment needs to be tailored, according to the causes themselves, to resolve the symptoms. Aim To assess the prevalence of GERD in a population of postmenopausal women affected by MVP and determine if there is any correlation between the two conditions. Methods The MVP diagnosis was performed using echocardiograpy examination, according to American Society Echocardiography criteria. Two hundred and eighty‐nine consecutive MVP women, symptomatic for chest pain and palpitation, were included; 250 consecutive women without MVP, symptomatic for chest pain and palpitation, were the control group (CG). The GERD diagnosis was made according to 2013 American College Gastroenterology criteria; women affected by thyroid disorders, all heart disease, including mitral disease with moderate or severe mitral regurgitation, and gastrointestinal diseases assessed using gastroscopy were excluded. Results Among 289 women with MVP, 31 (11%) women were affected by GERD, and among 250 in the CG, 11 (4.4%) women were affected by GERD: Chi‐squared 8.1; odds ratio 2.7; P < 0.0044. Twenty‐six (9%) women affected by GERD, with MVP, presented with mild mitral regurgitation, and 7 (2.8%) women in the CG presented with mild mitral regurgitation as well: Chi‐squared 8.95; odds ratio 3.4; 95% CI, P < 0.0028. Discussion and conclusions GERD is relatively common in women with MVP. Moreover, women with MVP are approximately three times more likely to be affected by GERD; the two conditions are correlated in a statistically high significant way. GERD assessment needs to be included into routine follow‐up strategies in women with MVP to optimise medical therapy, improvinge symptom relief for better quality of life.

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Overlap of GERD and gastrointestinal functional disorders

Cited by 7 publications

References 0 publications

Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse Population

Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse Population

Gastric emptying and related symptoms in patients treated with buspirone, amitriptyline or clebopride: a "real world" study by 13C-octanoic Acid Breath Test

Chest pain and palpitations in postmenopausal women with mitral valve prolapse: is there a gastro‐oesophageal origin?

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