Overlap Parasomnia Disorder in a case of Creutzfeldt-Jakob Disease

Puligheddu, Monica; Congiu, Patrizia; Laccu, Ilaria; Figorilli, Michela; Gioi, Gioia; Polizzi, Lorenzo; Pisanu, Patrizia; Marrosu, Francesco; Provini, Federica

doi:10.1016/j.sleep.2017.05.014

Cited by 11 publications

(3 citation statements)

References 8 publications

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“…This study suggests that RBD is as common in CJD patients as it is in patients with synucleinopathies. RBD in CJD might result from corticothalamic degeneration [102]. Due to methodology and limited sample size, larger studies involving multiple centers are needed.…”

Section: Rbd and Creutzfeldt-jakob Diseasementioning

confidence: 99%

Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update

et al. 2020

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Rapid eye movement sleep behavior disorder (RBD) is a sleep behavior disorder characterized by abnormal behaviors and loss of muscle atonia during rapid eye movement (REM) sleep. RBD is generally considered to be associated with synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), and usually precedes years before the first symptom of these diseases. It is believed that RBD predicts the neurodegeneration in synucleinopathy. However, increasing evidences have shown that RBD is also found in non-synucleinopathy neurodegenerative diseases, including Alzheimer's disease (AD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), etc. Sleep disturbance such as RBD may be an early sign of neurodegeneration in these diseases, and also serve as an assessment of cognitive impairments. In this review, we updated the clinical characteristics, diagnosis, and possible mechanisms of RBD in neurogenerative diseases. A better understanding of RBD in these neurogenerative diseases will provide biomarkers and novel therapeutics for the early diagnosis and treatment of the diseases.

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Section: Rbd and Creutzfeldt-jakob Diseasementioning

confidence: 99%

Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update

et al. 2020

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“…80 Most studies of DEB on patients with movement disorders focused primarily on RBD. These include: tauopathies such as progressive supranuclear palsy, 88,89,99 Huntington chorea, 136 Creutzfeldt-Jakob disease, 137,138 and Guadeloupean atypical parkinsonism. 139 However, studies to date were all either case reports or case series; larger cohort studies will be needed to determine the prevalence rate.…”

Section: Synucleinopathies and Degenerative Movement Disordersmentioning

confidence: 99%

Dream enactment behavior: review for the clinician

Baltzan

Yao

Rizzo

et al. 2020

Journal of Clinical Sleep Medicine

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Dream enactment behavior commonly occurs on occasion in normal children and adults. Disruptive and frequent dream enactment behavior may come to the attention of the clinician either as the primary reason for consultation or as a prominent characteristic of a patient with other sleep disorders. Questioning patients with chronic neurologic and psychiatric disorders may also reveal previously unrecognized behavior. In the absence of sleep pathology, process of dream enactment likely begins with active, often emotionally charged dream content that may occasionally break through the normal REM sleep motor suppressive activity. Disrupted sleep resulting from many possible causes, such as circadian disruption, sleep apnea, or medications, may also disrupt at least temporarily the motorsuppressive activity in REM sleep, allowing dream enactment to occur. Finally, pathological neurological damage in the context of degenerative, autoimmune, and infectious neurological disorders may lead to chronic recurrent and severe dream enactment behavior. Evaluating the context, frequency, and severity of dream enactment behavior is guided first and foremost by a structured approach to the sleep history. Physical exam and selected testing support the clinical diagnosis. Understanding the context and the likely cause is essential to effective therapy.

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“…Parasomnia overlap disorder represents an extreme breakdown of state boundaries in which there is a mixture, or rapid cycling, of NREM, REM, and wakefulness (Schenck and Mahowald, 2005;Castelnovo et al, 2018;Schenck and Howell, 2019). It is related to various nervous system diseases, mental diseases, and other sleep diseases, including narcolepsy, multiple sclerosis, Creutzfeldt-Jakob disease (Puligheddu et al, 2017), drug abuse, and sleep disordered breathing (Bugalho et al, 2017). In this case, POD symptoms were triggered by sleep disordered breathing.…”

Section: Discussionmentioning

confidence: 93%

Case Report: Parasomnia Overlap Disorder Induced by Obstructive Sleep Hypopnea Apnea Syndrome: A Case Report and Literature Review

Sun

Zhang

et al. 2020

Front. Neurosci.

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Obstructive sleep apnea hypopnea syndrome (OSAHS) and parasomnia overlap disorder (POD) are types of sleep disorders. When the symptoms of both conditions coexist, the POD symptoms are most likely caused by OSAHS. In these cases, the symptoms of POD will be relieved when OSAHS is effectively treated. We refer to these cases as symptomatic POD (related to OSAHS), which differs in pathophysiology, complications, and treatment from idiopathic POD. It is important to note that the treatment for idiopathic POD may aggravate the symptoms of OSAHS. In this case, we used video polysomnography (v-PSG) on a POD patient with suspected OSAHS to distinguish idiopathic POD from symptomatic POD, to inform the appropriate treatment course. The video results and clinical features lead us to diagnose symptomatic POD, and we treated the patient with auto-set continuous positive airway pressure to address their OSAHS. This course of treatment resolved all POD-related symptoms. Here, we discuss this case and review the relevant literature. This report highlights the importance of the use of v-PSG in the clinical diagnosis, differential diagnosis, and subsequent treatment of POD.

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Overlap Parasomnia Disorder in a case of Creutzfeldt-Jakob Disease

Cited by 11 publications

References 8 publications

Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update

Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update

Dream enactment behavior: review for the clinician

Case Report: Parasomnia Overlap Disorder Induced by Obstructive Sleep Hypopnea Apnea Syndrome: A Case Report and Literature Review

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