Overlap syndrome in Crohn’s disease

Abstract

The diagnosis of inflammatory bowel diseases (IBD) in children can be challenging for pediatricians. Extra-intestinal manifestations, such as hepatobiliary pathology, often complicate the diagnosis of these conditions. Hepatobiliary pathology is often an extraintestinal manifestation of inflammatory bowel disease. Patients with combined liver pathology (autoimmune hepatitis and primary sclerosing cholangitis) and inflammatory bowel disease have a higher risk of resistance to treatment, the need for liver transplantation, and a worse prognosis for liver cirrhosis compared to those with isolated liver disease. The article presents a clinical case of the development of overlap syndrome (a combination of autoimmune hepatitis and primary sclerosing cholangitis) in Crohn’s disease in a 7-year-old patient.