Overlapping deletion regions at 11q23 in myelodysplastic syndrome and chronic lymphocytic leukemia, characterized by a novel BAC probe set

Lee, Ann Siew‐Gek; Rudduck-Sivaswaren, Christina; Lie, Daniel Khun-Hong; Chua, Constance; Tien, Sim Leng; Morsberger, Laura; Griffin, Constance A.

doi:10.1016/j.cancergencyto.2004.01.007

Cited by 5 publications

(1 citation statement)

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“…The MLL gene rearrangement often occurs in acute myelocytic leukemia (AML), acute lymphoblastic leukemia, and myelodysplastic syndrome. In hematologic malignancies such as CLL, the most common abnormality is the deletion of the MLL(11q23) , [ 19 ] whereas the MLL gene rearrangement has not been previously observed in CLL. In this study, we revealed this interesting 3-way translocation of the MLL gene rearrangement; whether it contributes to the leukemia progression or even an unfavorable prognosis in CLL warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of t(2;14;11)(p16.1;q32;q23) and t(14;19)(q32;q13.3) chromosome translocations in a patient with chronic lymphocytic leukemia

Wen

Lu²,

Kim³

et al. 2017

Medicine

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Rationale:With combination of multiple techniques, we have successfully characterized unique, complex chromosomal changes in a patient with chronic lymphocytic leukemia (CLL), a lymphoproliferative disorder.Diagnoses:The diagnosis was based on white blood cell, flow cytometry, and immunophenotypes and confirmed by karyotype, fluorescence in situ hybridization, and array comparative genomic hybridization from the patient's blood culture.Interventions:The patient was given fludarabine, cyclophosphamide and rituximab (FCR) for 6 cycles.Outcomes:After completion of 6 cycles of FCR, the computed tomography scans of the neck/chest/abdomen/pelvic showed that the patient in CR. During the 10-month follow-up, the patient's clinical course remained uneventful.Lessons:The translocation t(14;19) identified in this patient is a recurrent translocation found in patients with chronic B-cell lymphoproliferative disorders and the 3-way translocation involving chromosomes 2, 14, and 11 may play a role as an enhancer.

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Section: Discussionmentioning

confidence: 99%