Overlapping immunoglobulin G4-related disease and Rosai–Dorfman disease mimicking lung cancer

Jong, Wouter K. de; Kluin, Philip M.; Groen, HarryJ.M.

doi:10.1183/09059180.00001612

Cited by 21 publications

(10 citation statements)

References 11 publications

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“…The relationship between RDD and IgG4-RD, not only in skin 8 but also in lung, [26][27][28] breast, 29 heart, 30 parotid, 31 and colon, 32 has been studied in case reports or small series and in 2 recent relatively large series of cases of nodal and extranodal RDD. 24,33 Zhang et al 24 found a mild increase in the absolute number of IgG4+ cells in 19/26 and a IgG/IgG4 ratio greater than 40% in 8/26 RDD specimens, with significantly higher numbers of FOXP3 T regulatory cells (which, together with T-helper 2 cells, regulate the production of IgG4+ cells) in RDD than in controls.…”

Section: Discussionmentioning

confidence: 98%

Primary Cutaneous Marginal IgG4 Lymphoma and Rosai–Dorfman's Disease Coexisting in Several Lesions of the Same Patient

Machan¹,

Medina

Rodríguez‐Pinilla

et al. 2015

The American Journal of Dermatopathology

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We report the unique association of primary cutaneous marginal zone B-cell lymphoma and Rosai-Dorfman disease (RDD)-type histiocytic infiltrates involving the same lesions. The patient was an 82-year-old woman with 3 long-standing, well-circumscribed firm erythematous to brownish plaques on her left arm, right scapular area, and lumbosacral area. Histopathologic examination disclosed a dermal and subcutaneous nodular lymphoplasmacytic infiltrate with evidence of germinal center colonization and light-chain restriction and sheets of S-100 CD68-positive histiocytes with ample pale cytoplasm and occasional emperipolesis of lymphocytes. The neoplastic plasma cells expressed immunoglobulin (Ig) G4. A review of 14 examples of cutaneous RDD showed a substantial number of IgG4-positive cells in only 3 of them, and a review of 8 primary cutaneous marginal zone B-cell lymphomas disclosed only 2 with significant IgG4 expression. The coexistence of lymphomas and RDD has been rarely reported in the literature but only seldom involving the same lymph node and-to the best of our knowledge-never in the skin.

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Section: Discussionmentioning

confidence: 98%

Primary Cutaneous Marginal IgG4 Lymphoma and Rosai–Dorfman's Disease Coexisting in Several Lesions of the Same Patient

Machan¹,

Medina

Rodríguez‐Pinilla

et al. 2015

The American Journal of Dermatopathology

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“…In contrast, in the IgG4-associated classical RDD, a polyclonal proliferation of IgG4 positive plasma cells and high levels of plasma IG4 levels are observed [158]. This is possibly representing a continuum of RDD to the recently defined nosological entity of IgG4-related disease, which is a chronic immune-mediated fibro-inflammatory condition involving multiple organs, like exocrine and endocrine glands, orbit, retroperitoneum [30,63,158]. Organ fibrosis or sclerosis with infiltration by IgG4 positive plasma cells may lead to secondary organ dysfunction, requiring systemic therapy, which is mainly based on steroids [30].…”

Section: Igg4-associated Classical Rddmentioning

confidence: 99%

“…Further, IgG4 levels may be used as a marker for disease activity. The causal relationship between RDD and IgG4 syndrome, however, is still not quite clear [63,159,226,235].…”

Section: Igg4-associated Classical Rddmentioning

confidence: 99%

The Non-Langerhans Cell Histiocytoses (Rare Histiocytoses) – Clinical Aspects and Therapeutic Approaches

2016

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Rare histiocytoses, also called non-Langerhans cell histiocytoses, include all proliferative disorders of histiocytes, macrophages and dendritic cells that are not classified as Langerhans cell histiocytosis (LCH) and do not belong to the hemophagocytic lymphohistiocytosis (HLH) group of diseases. Thus, the term includes numerous benign or malignant, localized or systemic, adult or pediatric diseases. The classification of the histiocytic disorders has been revised several times. Here, we follow the classification recently published by Jean Francois Emile and an international expert panel, defining subgroups of histiocytoses described as L-Group, C-Group, M-Group, R-Group, and H-Group, which stands for LCH-like, cutaneous or mucocutaneous, malignant, Rosai-Dorfman-Disease like and HLH like. Some of the diseases have an excellent prognosis after resection or even disappear spontanously, others progress rapidly, requiring intensive systemic therapies. The malignant non-Langerhans cell histiocytoses in general have a poor prognosis, here, complex chemotherapy protocols are usually applied, with inconsistant results. An interesting perspective in non-malignant rare histiocytoses might be small molecular inhibitors, in particular BRAF inhibitors, since BRAF mutations have been found in some subtypes of non-Langerhans cell histiocytoses. By prospective and retrospective collection of experiences in a new registry (the "International Rare Histiocytic Disorders Registry", IRHDR), knowledge about these rare diseases might hopefully be improved.

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“…RDD, a disease characterized by non-clonal S100 positive histiocyte proliferation, shows a lymphangitic distribution on imaging and IgG4þ plasma cell infiltrates in tissues [44]. Overlapping histopathologic findings of IgG4-RD and RDD have been observed in some patients [45,46]. Although RDD is rare, its relationship to IgG4-RD requires further study.…”

Section: Rosai-dorfman Disease (Rdd)mentioning

confidence: 99%

IgG4-related respiratory disease

Matsui

2019

Modern Rheumatology

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IgG4-related diseases (IgG4-RDs), such as autoimmune pancreatitis and IgG4-related Mikulicz disease, are often accompanied by intrathoracic lesions, which are called IgG4-related respiratory disease (IgG4-RRD). IgG4-RRD has few subjective symptoms, and is usually detected during workup of patients with extra-thoracic lesions of IgG4-RD. IgG4-RRD is characterized by various conditions, including masses, nodules, thickening, and infiltration at numerous sites in the thorax through lymphatic routes. Although elevated serum IgG4 concentrations and pathologic evidence of lymphoplasmacytic infiltrates with abundant IgG4-positive plasma cells are characteristic findings of IgG4-RD, other intrathoracic diseases, such as multicentric Castleman disease and malignancy, may present with similar findings. Developing diagnostic criteria for IgG4-RRD, including clinicoradiological and pathological characteristics, is necessary for its appropriate diagnosis.

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Overlapping immunoglobulin G4-related disease and Rosai–Dorfman disease mimicking lung cancer

Cited by 21 publications

References 11 publications

Primary Cutaneous Marginal IgG4 Lymphoma and Rosai–Dorfman's Disease Coexisting in Several Lesions of the Same Patient

Primary Cutaneous Marginal IgG4 Lymphoma and Rosai–Dorfman's Disease Coexisting in Several Lesions of the Same Patient

The Non-Langerhans Cell Histiocytoses (Rare Histiocytoses) – Clinical Aspects and Therapeutic Approaches

IgG4-related respiratory disease

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