2016
DOI: 10.3389/fmicb.2016.01735
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Overlapping Regions in HIV-1 Genome Act as Potential Sites for Host–Virus Interaction

Abstract: More than a decade, overlapping genes in RNA viruses became a subject of research which has explored various effect of gene overlapping on the evolution and function of viral genomes like genome size compaction. Additionally, overlapping regions (OVRs) are also reported to encode elevated degree of protein intrinsic disorder (PID) in unspliced RNA viruses. With the aim to explore the roles of OVRs in HIV-1 pathogenesis, we have carried out an in-depth analysis on the association of gene overlapping with PID in… Show more

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Cited by 3 publications
(5 citation statements)
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“…Furin protease is ubiquitously expressed in a wide range of organs and tissues, including the brain, lung, gastrointestinal tract, liver, pancreas, and reproductive tissues. The structural flexibility of IDR stimulates this region sensitive to proteolysis 35,43 . Similar kind of observation was also reported in Zika virus where the prefusion protein prM contains IDR with a protease cleavage site 44 .…”
Section: Discussionsupporting
confidence: 72%
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“…Furin protease is ubiquitously expressed in a wide range of organs and tissues, including the brain, lung, gastrointestinal tract, liver, pancreas, and reproductive tissues. The structural flexibility of IDR stimulates this region sensitive to proteolysis 35,43 . Similar kind of observation was also reported in Zika virus where the prefusion protein prM contains IDR with a protease cleavage site 44 .…”
Section: Discussionsupporting
confidence: 72%
“…The structural flexibility of IDR stimulates this region sensitive to proteolysis. 35,43 Similar kind of observation was also reported in Zika virus where the prefusion protein prM contains IDR with a protease cleavage site. 44 Thus, the acquisition of a disordered region imposes efficient proteolytic cleavage of S2 which in turn activates fusion peptide to fuse with the host membrane.…”
Section: Discussionsupporting
confidence: 67%
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“…There are several explanations for the abundance of overlapping genes in RNA viruses. The appearance of OGs (i) helps viruses to compress a maximum amount of information into short sequences (Belshaw et al, 2008 ) and increase their fitness in various hosts (Krakauer, 2000 ), (ii) constitutes a mechanism of gene expression regulation via translational coupling of functionally related polypeptides (Belshaw et al, 2007 ), and (iii) represents an effective mechanism for novel gene generation by introducing a new open reading frame (ORF) over an existing one (Pavesi et al, 2013 ; Simon-Loriere et al, 2013 ; Saha et al, 2016 ).…”
Section: Introductionmentioning
confidence: 99%