Overlooked hematological markers of disease activity in rheumatoid arthritis

Tekeoğlu, İbrahim; Gürol, Gönül; Harman, Halil; Karakeçe, Engin; Çiftçi, İhsan Hakkı

doi:10.1111/1756-185x.12805

Cited by 62 publications

(71 citation statements)

References 16 publications

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“…25,26 Kisacik et al 16 have shown that the MPV values in patients with ankylosing spondylitis and RA were significantly lower than controls and there was a significant negative correlation between the MPV value and the level of disease activity. The study of Tekeoglu et al 8 supports this study and found a negative correlation between MPV values and disease activity. Yazici et al 25 found that the MPV values in RA patients were positively correlated with both DAS28 and disease activity levels.…”

Section: Discussionsupporting

confidence: 81%

“…22,23 NLR has been shown to be higher in RA group compared to control group and associated with disease activity in several publications. [8][9][10] We also found that NLR was higher in RA patients than the control group and a positive significant correlation was present with DAS28.…”

Section: Discussionsupporting

confidence: 64%

“…6,7 In recent years, it was shown that these markers may be associated with disease activity in RA as well. [8][9][10] Pentraxins (PTXs) are separated into two groups, short and long PTXs. While PTX3 is a prototypical long PTX, acute phase reactants CRP and serum amyloid P are short PTXs.…”

mentioning

confidence: 99%

“…NRL has also been associated with disease activity in RA. [8][9][10] Therefore, in this study, we aimed to investigate the association of PTX3 with NLR rather than the DAS28 disease activity score using CRP in RA. 14 The venous blood of each patient was taken from the antecubital area in the morning after an overnight fast.…”

mentioning

confidence: 99%

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The Relationship Between Serum Pentraxine 3 Levels and Hematological Markers in Patients With Rheumatoid Arthritis

Sağ

Tekeoğlu

et al. 2018

Arch Rheumatol

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Objectives: This study aims to investigate the association of pentraxin 3 (PTX3) with neutrophil/lymphocyte ratio (NLR) rather than the disease activity score 28 using C-reactive protein in rheumatoid arthritis (RA). Patients and methods:The study included 59 RA patients (11 males, 48 females; mean age 53.79±13.55 years; range 40 to 66 years) and 20 healthy controls (5 males, 15 females; mean age 50.41±6.11 years; range 43 to 56 years). Complete blood count tests were recorded and NLR and platelet/lymphocyte ratio were calculated. PTX3 and interleukin-6 levels were examined in serum samples. Disease activity of RA patients was assessed by disease activity score 28. Results: Demographic characteristics were similar between the two groups, with no statistically significant difference in terms of sex, age, and body mass index (p>0.05). NLR, PTX3 and interleukin-6 levels were higher in patients with RA than the control group (p<0.05). While erythrocyte sedimentation rate had a positive correlation with mean platelet volume, we found no correlation between NLR and other parameters of disease activity, PTX3, and interleukin-6. Conclusion: We found no correlation between PTX3 and disease activity score 28 or NLR, although PTX3 levels were higher in RA patients than the controls. As a result, we were unable to establish a relationship between PTX3 and disease activity, directly or indirectly. To our knowledge, our study was the first to investigate the relationship between PTX3 and NLR.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 64%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The Relationship Between Serum Pentraxine 3 Levels and Hematological Markers in Patients With Rheumatoid Arthritis

Sağ

Tekeoğlu

et al. 2018

Arch Rheumatol

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“…We support that vitamin B12-deficient patients have inflammatory conditions and MPV reflects the inflammatory position. Similarly, MPV was found to have a relationship with some inflammatory processes such as coronary ischemia, preeclampsia, ischemic stroke, rheumatoid arthritis, and inflammatory bowel disease [25][26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

The Relationship of Vitamin B12 Deficiency and Red Cell Distribution Width-Platelet Ratio

Yılmaz¹,

Yılmaz²

2016

J Clin Exp Invest

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Objective: We aimed to investigate the relationship between vitamin B12 deficiency and red cell distribution widthplatelet ratio (RPR), and the variations in the parameters on vitamin B12 treatment.Methods: One hundred fifty-four patients with untreated vitamin B12 deficiency (56% men, mean age: 50 ± 12.7 years) (untreated group), 86 patients with vitamin B12 deficiency (62% men, mean age: 42 ± 20.7 years) on vitamin B12 treatment (treated group), and 92 age-and sex-matched control group (54% men, mean age: 45 ± 15.1 years) were included in the study. Hematological parameters were evaluated by the method of laser-based flow cytometric impedance, using an automated blood cell counter (ABX Pentra 120 Hematology Blood Analyzer).Results: RPR was significantly reduced in treated group compared with untreated group (4.88 ± 1.06; 6.13 ± 1.27; p<0.001, respectively). RPR, red cell distribution width (RDW) and mean platelet volume (MPV) were significantly different in untreated group compared to controls (p<0.05). There were no differences in platelet count in the three groups (p>0.05). Conclusion:We proposed that vitamin B12 deficiency has effects on RPR and supplementation with vitamin B12 corrects the RPR levels. Yöntemler: Çalışmaya 154 tedavi olmamış vitamin B12 hastası (%56'sı erkek, ort. yaş: 50 ± 12,7) (tedavi olmayan grup), 86 vitamin B12 eksikliği olan ve tedavi alan hastalar (%62'si erkek, ortalama yaş: 42 ± 20,7) (tedavi alan grup) ve 92 yaş ve cinsiyet uyumlu kontrol grubu (%54'ü erkek, ort. yaş: 45 ± 15,1 yıl) dahil edildi. Hematolojik parametreler, lazer tabanlı akım sitometri empedansı yöntemiyle otomatik kan hücre sayıcıyla (ABX Pentra 120 Hematology Blood Analyzer) ölçüldü.Bulgular: RPR, tedavi alan grupta tedavi almayan gruba göre anlamlı olarak düşük tespit edildi (4,88 ± 1,06; 6,13 ± 1,27; p<0.001, sırasıyla). RPR, eritrosit dağılım genişliği ve ortalama trombosit hacmi tedavi almayan grupta kontrol grubuyla karşılaştırıldığında anlamlı fark vardı (p<0.05). Üç grup arasında, trombosit sayılarıyla anlamlı fark yoktu (p>0.05).

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The clinical value of hematological markers in rheumatoid arthritis patients treated with tocilizumab

Zhou

Xiao

Qin

et al. 2019

Clinical Laboratory Analysis

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BackgroundEmerging evidence indicates that some hematological markers have critical value in evaluating treatment response. This study was performed to determine the clinical value of hemoglobin (Hb), platelet (Plt), neutrophil‐to‐lymphocyte ratio (NLR), and platelet‐to‐lymphocyte ratio (PLR) in rheumatoid arthritis (RA) patients treated with tocilizumab (TCZ).MethodsFifty‐two RA patients receiving TCZ were recruited and followed for 6 months. The values of abovementioned hematological markers were collected. Clinical disease activity index (CDAI) and disease activity score based on 28 joints (DAS28)‐ESR were calculated. Correlation analysis was conducted by calculating Pearson's correlation coefficient. The change in disease activity between groups according to the baseline level of hematological markers was compared by t test.ResultsSignificant correlation between change in NLR (△NLR), change in PLR (△PLR), and change in CDAI (△CDAI) was found (△NLR: r = 0.30, P = 0.03; △PLR: r = 0.31, P = 0.03). The change in Plt (△Plt) was correlated with change in DAS28‐ESR (△DAS28‐ESR) (r = 0.36, P = 8.24 × 10−3). Greater improvement in CDAI was seen in patients categorized into Plt high group (t = 2.06, P = 0.04), NLR high group (t = 2.15, P = 0.04), and PLR high group (t = 2.41, P = 0.02) compared with the contrast group.ConclusionOur study demonstrated that △Plt, △NLR, and △PLR could be used to monitor the clinical response to TCZ. RA patients with high baseline levels of Plt, NLR, and PLR achieved more improvement, indicating these hematological markers might be utilized to guide TCZ treatment.

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Overlooked hematological markers of disease activity in rheumatoid arthritis

Cited by 62 publications

References 16 publications

The Relationship Between Serum Pentraxine 3 Levels and Hematological Markers in Patients With Rheumatoid Arthritis

The Relationship Between Serum Pentraxine 3 Levels and Hematological Markers in Patients With Rheumatoid Arthritis

The Relationship of Vitamin B12 Deficiency and Red Cell Distribution Width-Platelet Ratio

The clinical value of hematological markers in rheumatoid arthritis patients treated with tocilizumab

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