2021
DOI: 10.3389/fnins.2020.609670
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Overnight Caloric Restriction Prior to Cardiac Arrest and Resuscitation Leads to Improved Survival and Neurological Outcome in a Rodent Model

Abstract: While interest toward caloric restriction (CR) in various models of brain injury has increased in recent decades, studies have predominantly focused on the benefits of chronic or intermittent CR. The effects of ultra-short, including overnight, CR on acute ischemic brain injury are not well studied. Here, we show that overnight caloric restriction (75% over 14 h) prior to asphyxial cardiac arrest and resuscitation (CA) improves survival and neurological recovery as measured by, behavioral testing on neurologic… Show more

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Cited by 5 publications
(6 citation statements)
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“…Likewise, 1/f slope might also be used to differentiate or prognosticate coma status in parallel with existing burst suppression metrics, or even perhaps guide pharmacological interventions on coma. For example, the time to resumption of EEG bursting after cardiac arrest depends on cerebral perfusion [Crouzet et al, 2016, Azadian et al, 2021, Wilson et al, 2019], so 1/f slope analysis of this bursting state might constrain microcircuit models of how re-perfusion modulates neuronal dynamics. Thus, the present model of 1/f slope may be used to further understanding of how different anesthetics modulate the synchronization of neural circuits and subsequently alter consciousness.…”
Section: Discussionmentioning
confidence: 99%
“…Likewise, 1/f slope might also be used to differentiate or prognosticate coma status in parallel with existing burst suppression metrics, or even perhaps guide pharmacological interventions on coma. For example, the time to resumption of EEG bursting after cardiac arrest depends on cerebral perfusion [Crouzet et al, 2016, Azadian et al, 2021, Wilson et al, 2019], so 1/f slope analysis of this bursting state might constrain microcircuit models of how re-perfusion modulates neuronal dynamics. Thus, the present model of 1/f slope may be used to further understanding of how different anesthetics modulate the synchronization of neural circuits and subsequently alter consciousness.…”
Section: Discussionmentioning
confidence: 99%
“…The animal model of asphyxial cardiac arrest and resuscitation used in this study has been described previously [ 9 , 26 28 ] by our laboratory and is summarized in Fig. 1 .…”
Section: Methodsmentioning
confidence: 99%
“…Briefly, male Wistar rats (Charles River Laboratories) of 8 to 12 weeks of age weighing 300 to 400 g were handled daily for at least 1 week prior to any experimentation. The night prior to cardiac arrest experiments, rats were calorically restricted (75% restriction) with three food pellets, as is standard with our model [ 26 ]. The next morning, rats were endotracheally intubated and received femoral artery and vein cannulation to enable arterial blood pressure monitoring and venous drug delivery, respectively.…”
Section: Methodsmentioning
confidence: 99%
“…This monitoring was performed during entry into cardiac arrest, CPR, and reperfusion in a setup mimicking an intensive care unit. 61 , 76 , 200 , 214 This setup provided high-speed ( ) SFDI mapping of chromophores, which enabled the requisite temporal resolution to monitor rapid hemodynamic changes and calculate cerebral pulsatility. SFDI revealed rapid cerebral changes in the hemoglobin concentrations and oxygenation during cardiac arrest and immediately post-CPR that were distinct from changes in the tissue during these same time periods [ Fig.…”
Section: Applicationsmentioning
confidence: 99%