Overproduction of TNF-α and lung structural remodelling due to chronic exposure to volcanogenic air pollution

Camarinho, Ricardo; Garcia, Patrícia; Choi, Hye‐Seon; Rodrigues, Armindo

doi:10.1016/j.chemosphere.2019.01.138

Cited by 16 publications

(16 citation statements)

References 45 publications

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“…In line with these results, rodents exposed to PM for a prolonged period exhibited altered neuronal and astrocytic functions via impairment of mitochondrial activity (Araújo et al, 2019). Likewise, exposure of rodents to natural air pollution sources, such as volcanic-derived particles, increased GFAP immunoreactivity in astrocytes (Camarinho et al, 2019;Navarro et al, 2021). Moreover, exposure of rodents to low doses of CB-NP induced endoplasmic reticulum (ER) stress in perivascular macrophages and reactive astrocytes, specifically around the vasculature of offspring animals, associated with the accumulation of β-sheet rich misfolded proteins (Onoda et al, 2020).…”

Section: Impact On the Dynamics Of Astrocytes And Oligodendrocytessupporting

confidence: 52%

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors

Lecordier

Manrique-Castano

Moghrabi

et al. 2021

Front. Aging Neurosci.

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Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the world after Alzheimer’s disease (AD). VaD regroups heterogeneous neurological conditions in which the decline of cognitive functions, including executive functions, is associated with structural and functional alterations in the cerebral vasculature. Among these cerebrovascular disorders, major stroke, and cerebral small vessel disease (cSVD) constitute the major risk factors for VaD. These conditions alter neurovascular functions leading to blood-brain barrier (BBB) deregulation, neurovascular coupling dysfunction, and inflammation. Accumulation of neurovascular impairments over time underlies the cognitive function decline associated with VaD. Furthermore, several vascular risk factors, such as hypertension, obesity, and diabetes have been shown to exacerbate neurovascular impairments and thus increase VaD prevalence. Importantly, air pollution constitutes an underestimated risk factor that triggers vascular dysfunction via inflammation and oxidative stress. The review summarizes the current knowledge related to the pathological mechanisms linking neurovascular impairments associated with stroke, cSVD, and vascular risk factors with a particular emphasis on air pollution, to VaD etiology and progression. Furthermore, the review discusses the major challenges to fully elucidate the pathobiology of VaD, as well as research directions to outline new therapeutic interventions.

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Section: Impact On the Dynamics Of Astrocytes And Oligodendrocytessupporting

confidence: 52%

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors

Lecordier

Manrique-Castano

Moghrabi

et al. 2021

Front. Aging Neurosci.

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“…The Azores archipelago is a volcanic area with several manifestations of active volcanism, making it an ideal place to study environmental health problems [ 70 ]. Previous research has shown that volcanic areas are associated with an increased incidence of a wide range of diseases [ 55 , 59 , 60 , 71 – 74 ]. However, very little is known about the consequences on the nervous system of people inhabiting volcanic environments.…”

Section: Discussionmentioning

confidence: 99%

The Health Hazards of Volcanoes: First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings

Navarro‐Sempere

Martínez-Peinado

Rodrigues

et al. 2021

Mediators of Inflammation

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Neuroinflammation is a process related to the onset of neurodegenerative diseases; one of the hallmarks of this process is microglial reactivation and the secretion by these cells of proinflammatory cytokines such as TNFα. Numerous studies report the relationship between neuroinflammatory processes and exposure to anthropogenic air pollutants, but few refer to natural pollutants. Volcanoes are highly inhabited natural sources of environmental pollution that induce changes in the nervous system, such as reactive astrogliosis or the blood-brain barrier breakdown in exposed individuals; however, no neuroinflammatory event has been yet defined. To this purpose, we studied resting microglia, reactive microglia, and TNFα production in the brains of mice chronically exposed to an active volcanic environment on the island of São Miguel (Azores, Portugal). For the first time, we demonstrate a proliferation of microglial cells and an increase in reactive microglia, as well an increase in TNFα secretion, in the central nervous system of individuals exposed to volcanogenic pollutants.

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“…The normative immunologic response to air pollution, including during pregnancy (27), induces pro-in ammatory responses evidenced by heightened cytokine production and serum c-reactive protein levels. (27,32,(37)(38)(39)(40) Exposure to chronic stress leads to excessive release of stress hormones resulting in physiologic dysregulation, including impaired immune function, and consequent excessive in ammation. (42,43) Evidence of immune function in regards to ethnic enclave residence is seen among Hispanic women, as those residing in ethnic enclaves have lower risk of allostatic load (dysfunction across multiple physiologic domains including impaired immune function), compared to those residing in non-enclave areas.…”

Section: Discussionmentioning

confidence: 99%

Joint effects of ethnic enclave residence and ambient volatile organic compounds exposure on risk of gestational diabetes mellitus among Asian/Pacific Islander women in the United States

Williams

Shenassa

et al. 2021

Preprint

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Background: Asian/Pacific Islander (API) communities in the United States often reside in metropolitan areas with distinct social and environmental attributes. Residence in an ethnic enclave, a socially distinct area, is associated with lower gestational diabetes mellitus (GDM) risk, yet exposure to high levels of air pollution, including volatile organic compounds (VOCS), is associated with increased GDM risk. We examined the joint effects of ethnic enclaves and VOCs to better understand GDM risk among API women, the group with the highest prevalence of GDM.Methods: We examined 9,069 API births in the Consortium on Safe Labor (19 hospitals, 2002-2008). API ethnic enclaves were defined as areas ≥66th percentile for percent API residents, dissimilarity (geographic dispersal of API and White residents), and isolation (degree that API individuals interact with another API individual). High levels of 14 volatile organic compounds (VOC) were defined as ≥75th percentile. Four joint categories were created for each VOC: Low VOC/Enclave (reference group), Low VOC/No Enclave, High VOC/Enclave, High VOC/No Enclave. GDM was reported in medical records. Hierarchical logistic regression estimated odds ratios (OR) and 95% confidence intervals (95%CI) between joint exposures and GDM, adjusted for maternal factors and area-level poverty. Risk was estimated for 3-months preconception and first trimester exposures.Results: Enclave residence was associated with lower GDM risk regardless of VOC exposure. Preconception benzene exposure was associated with increased risk when women resided outside enclaves [High VOC/No Enclave (OR:3.45, 95%CI:1.77,6.72)], and the effect was somewhat mitigated within enclaves, [High VOC/Enclave (OR:2.07, 95%:1.09,3.94)]. Risks were similar for 12 of 14 VOCs during preconception and 10 of 14 during the first trimester.Conclusions: API residence in non-enclave areas is associated with higher GDM risk, regardless of VOC level. Ethnic enclave residence may mitigate effects of VOC exposure, perhaps due to lower stress levels. The potential benefit of ethnic enclaves warrants further study.

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Overproduction of TNF-α and lung structural remodelling due to chronic exposure to volcanogenic air pollution

Cited by 16 publications

References 45 publications

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors

The Health Hazards of Volcanoes: First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings

Joint effects of ethnic enclave residence and ambient volatile organic compounds exposure on risk of gestational diabetes mellitus among Asian/Pacific Islander women in the United States

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