Overt tumor regression after salvage boron neutron capture therapy (BNCT) for a recurrent glioblastoma patient

Lan, Tien-Li; Chou, Fong‐In; Huang, Wen‐Sheng; Lin, Ko-Han; Lee, Yi-Yen; Pan, Po-Shen; Kuo, Yu‐Cheng; Hsu, Shih-Ming; Chang, Frank; Liang, Mindy; Lee, Jia-Cheng; Lin, Shih‐Chieh; Liu, Yuming; Chao, Yee; Chen, Yiwei

doi:10.21037/tro.2018.10.09

Cited by 6 publications

(3 citation statements)

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“…In order to develop new protocols to establish clinical-scale trials, the optimization of both compound and neutron beams are especially important in light of this shift away from reactor-based sources. We believe that, based on the results of previous trials at nuclear reactors and accelerator-based neutron sources by other research groups [ 2 , 3 , 4 , 5 , 43 , 53 , 54 ], as well as our own data [ 19 , 21 , 22 , 23 , 24 , 26 , 50 , 55 ], biodistribution of boron-containing compounds with regard to accelerator-based neutron sources is the current and well-reported future of BNCT [ 26 , 43 ]. It was thus necessary to continue the selection of optimal conditions for such experiments.…”

Section: Discussionmentioning

confidence: 99%

Dose-Dependent Suppression of Human Glioblastoma Xenograft Growth by Accelerator-Based Boron Neutron Capture Therapy with Simultaneous Use of Two Boron-Containing Compounds

Kanygin

Разумов

Zaboronok

et al. 2021

Biology

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(1) Background: Developments in accelerator-based neutron sources moved boron neutron capture therapy (BNCT) to the next phase, where new neutron radiation parameters had to be studied for the treatment of cancers, including brain tumors. We aimed to further improve accelerator-BNCT efficacy by optimizing dosimetry control, beam parameters, and combinations of boronophenylalanine (BPA) and sodium borocaptate (BSH) administration in U87MG xenograft-bearing immunodeficient mice with two different tumor locations. (2) Methods: The study included two sets of experiments. In Experiment #1, BPA only and single or double irradiation in higher doses were used, while, in Experiment #2, BPA and BSH combinations and single or double irradiation with dosage adjustment were analyzed. Mice without treatment or irradiation after BPA or BPA+BSH injection were used as controls. (3) Results: Irradiation parameter adjustment and BPA and BSH combination led to 80–83% tumor-growth inhibition index scores, irradiation:BNCT ratios of 1:2, and increases in animal life expectancy from 9 to 107 days. (4) Conclusions: Adjustments in dosimetry control, calculation of irradiation doses, and combined use of two 10B compounds allowed for BNCT optimization that will be useful in the development of clinical-trial protocols for accelerator-based BNCT.

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Section: Discussionmentioning

confidence: 99%

Dose-Dependent Suppression of Human Glioblastoma Xenograft Growth by Accelerator-Based Boron Neutron Capture Therapy with Simultaneous Use of Two Boron-Containing Compounds

Kanygin

Разумов

Zaboronok

et al. 2021

Biology

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“…Taiwan é um dos dois únicos países que continuam com estudos clínicos (fases 1 e 2) de BNCT utilizando o reator para tratamento de câncer de cabeça e pescoço recorrente em alto estadiamento. Sua experiência na BNCT é ainda bem modesta comparada com os grupos japonês e finlandês, restringindo-se ao tratamento de dez pacientes com câncer de cabeça e pescoço e um caso de glioblastoma intracranial recorrente 15,16 .…”

Section: Taiwan (Formosa)unclassified

Princípios e aplicações da Terapia por Captura de Nêutrons por Boro – BNCT

Siqueira¹,

Yoriyaz²,

Shorto³

et al. 2019

Rev Bras Fis Med

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ResumoA terapia por captura de nêutrons (neutron capture therapy -NCT) é uma técnica radioterápica bimodal com princípios de funcionamento muito vantajosos para o tratamento de cânceres difusos. Contudo, apesar dessa vantagem conceitual e de sua primeira proposição já exceder 80 anos, essa técnica ainda não se encontra consolidada na comunidade clínica internacional como proposta terapêutica. Esse insucesso em seu estabelecimento não tem impedido que diversos grupos de pesquisa de diversos países do mundo invistam tempo e recursos em seu desenvolvimento. Neste texto apresentamos brevemente um histórico da NCT e dos principais desafios enfrentados pelos diversos grupos de pesquisas, uma comunidade de entusiastas da técnica, no seu desenvolvimento e na consolidação terapêutica da sua vertente mais estudada, a boron neutron capture therapy (BNCT). É apresentado também um resumo dos principais resultados alcançados com a técnica, além de um breve relato dos estudos realizados na instalação experimental de BNCT no Brasil. Palavras-chave: terapia por captura de nêutrons; boron neutron capture therapy; radioterapia; carregadores; fonte de nêutrons. AbstractNeutron Capture Therapy (NCT) is a bimodal radiotherapy technique with very advantageous operating principles for the treatment of diffuse cancer cells. However, despite its conceptual advantage and its already exceeding 80-year proposition time, NCT has not yet been consolidated in the international clinical community as a therapeutic alternative. The failure in its incorporation as a therapeutic procedure has not prevented several research groups from many countries around the world to have invested time and resources in its development. In this text, we briefly present a history of the NCT, and the main challenges faced by the various research groups, which form a community of enthusiasts of the technique, in its development and therapeutic consolidation of its most studied branch, the Boron Neutron Capture Therapy (BNCT). A summary of the main results achieved with the technique and a brief report of the studies carried out at the BNCT experimental facility in Brazil was also presented

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“…In the clinical treatment of brain tumors in Japan, in particular, it was reported that the patient's disease control period post-BNCT was significantly superior to that after traditional photon therapy alone, with patients not only surviving for more than 2 years, but also having excellent quality of life. In addition, for recurrent head and neck cancer, melanoma, liver cancer, and mesothelioma, etc., all countries have reported inspiring clinical trial results [3][4][5][6][7][8]. Therefore, with further improvement, this highly bioactive targeted radiotherapy will be able to assist a variety of clinical patients.…”

Section: Introductionmentioning

confidence: 99%

Boron Neutron Capture Therapy: A New Generation of Targeted Charged-Particle Radiotherapy

Chen

Chou

Huang

et al. 2019

BJSTR

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Radiation therapy plays an important role in standard cancer treatment. However, patients who are resistant to traditional radiation therapy or who have relapsed after conventional radiation therapy are often encountered in clinical practice. There is therefore a need for a new radiation therapy for this type of patient. Although boron neutron capture therapy is not a new concept of radiation therapy, due to technological breakthroughs and conceptual improvements at the start of the 21 st century, this therapy, which covers multidisciplinary technologies, such as medical physics, atomic science and technology, boron-containing drug synthesis, radiobiology, and clinical oncology has advanced greatly, and has gradually matured to a clinically useful therapy for patients with cancer. This article provides a brief introduction to the latest breakthroughs and progress in this technology.

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Overt tumor regression after salvage boron neutron capture therapy (BNCT) for a recurrent glioblastoma patient

Cited by 6 publications

References 0 publications

Dose-Dependent Suppression of Human Glioblastoma Xenograft Growth by Accelerator-Based Boron Neutron Capture Therapy with Simultaneous Use of Two Boron-Containing Compounds

Dose-Dependent Suppression of Human Glioblastoma Xenograft Growth by Accelerator-Based Boron Neutron Capture Therapy with Simultaneous Use of Two Boron-Containing Compounds

Princípios e aplicações da Terapia por Captura de Nêutrons por Boro – BNCT

Boron Neutron Capture Therapy: A New Generation of Targeted Charged-Particle Radiotherapy

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