Overtime reliability of medial temporal lobe atrophy rating in a clinical setting

Cavallin, Lena; Löken, Kirsti; Engedal, Knut; Øksengård, Anne-Rita; Wahlund, Lars‐Olof; Bronge, Lena; Axelsson, Rimma

doi:10.1258/ar.2012.110552

Cited by 36 publications

(28 citation statements)

References 19 publications

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“…Good interrater agreement has previously been demonstrated for L.C. in comparison with a second rater [25,33], manual tracings from another experienced radiologist [30], and multivariate classification from automated morphometric methods [29]. …”

Section: Methodsmentioning

confidence: 99%

Electroencephalography Is a Good Complement to Currently Established Dementia Biomarkers

Ferreira

Jelić

Cavallin

et al. 2016

Dement Geriatr Cogn Disord

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Background/Aims: Dementia biomarkers that are accessible and easily applicable in nonspecialized clinical settings are urgently needed. Quantitative electroencephalography (qEEG) is a good candidate, and the statistical pattern recognition (SPR) method has recently provided promising results. We tested the diagnostic value of qEEG-SPR in comparison to cognition, structural imaging, and cerebrospinal fluid (CSF) biomarkers. Methods: A total of 511 individuals were recruited from the multicenter NORD EEG study [141 healthy controls, 64 subjective cognitive decline, 124 mild cognitive impairment, 135 Alzheimer's disease (AD), 15 dementia with Lewy bodies/Parkinson's disease with dementia (DLB/PDD), 32 other dementias]. The EEG data were recorded in a standardized way. Structural imaging data were visually rated using scales of atrophy in the medial temporal, frontal, and posterior cortex. Results: qEEG-SPR outperformed structural imaging, cognition, and CSF biomarkers in DLB/PDD diagnosis, outperformed structural imaging in AD diagnosis, and improved the differential diagnosis of AD. In addition, qEEG-SPR allowed differentiation of two clinically different AD subtypes. Conclusion: Adding qEEG to the diagnostic workup substantially increases the detection of AD pathology even in pre-dementia stages and improves differential diagnosis. EEG could serve as a good complement to currently established dementia biomarkers since it is cheap, noninvasive, and extensively applied outside academic centers.

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Section: Methodsmentioning

confidence: 99%

Electroencephalography Is a Good Complement to Currently Established Dementia Biomarkers

Ferreira

Jelić

Cavallin

et al. 2016

Dement Geriatr Cogn Disord

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“…Since it was introduced, the Scheltens scale has been included in over 100 studies with several reporting improved sensitivity, specificity and reliability over the original study, even when used in a clinical setting 27. The reliability of the scale has been reported to be robust to the clinical experience of the rater28 but increases as the rater gains more experience with the scale itself 29. Improved performance of the scale may be due to advances in image acquisition and display, such as improved scanner hardware, higher field strengths (the original study was performed at 0.5 T and 0.6 T) and reporting of the images from digital display over hard copy film images.…”

Section: Visual Rating Of the Mtlmentioning

confidence: 99%

Using visual rating to diagnose dementia: a critical evaluation of MRI atrophy scales

Harper

Barkhof

Fox

et al. 2015

J Neurol Neurosurg Psychiatry

132

114

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Visual rating scales, developed to assess atrophy in patients with cognitive impairment, offer a cost-effective diagnostic tool that is ideally suited for implementation in clinical practice. By focusing attention on brain regions susceptible to change in dementia and enforcing structured reporting of these findings, visual rating can improve the sensitivity, reliability and diagnostic value of radiological image interpretation. Brain imaging is recommended in all current diagnostic guidelines relating to dementia, and recent guidelines have also recommended the application of medial temporal lobe atrophy rating. Despite these recommendations, and the ease with which rating scales can be applied, there is still relatively low uptake in routine clinical assessments. Careful consideration of atrophy rating scales is needed to verify their diagnostic potential and encourage uptake among clinicians. Determining the added value of combining scores from visual rating in different brain regions may also increase the diagnostic value of these tools.

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“…Additionally, Scheltens' coronal plane was obtained parallel to the brain stem axis from a midsagittal scout image with a slice thickness of 5 mm and an interslice gap of 1 mm on 0.5 or 0.6T MRI (29), which is different from the current MR acquisition technique to some extent. Recent studies employing the Scheltens 5-point scale with a modified oblique coronal plane perpendicular to the anterior-posterior commissure line with slice thicknesses between 0.8–4 mm have shown more promising results and better inter-observer reliability (weighed κ = 0.65–0.84) (2333). …”

Section: Structural Imagingmentioning

confidence: 99%

Structural MR Imaging in the Diagnosis of Alzheimer's Disease and Other Neurodegenerative Dementia: Current Imaging Approach and Future Perspectives

Park

Moon

2016

Korean J Radiol

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With the rise of aging population, clinical concern and research attention has shifted towards neuroimaging of dementia. The advent of 3T, magnetic resonance imaging (MRI) has permitted the anatomical imaging of neurodegenerative disease, specifically dementia, with improved resolution. Furthermore, more powerful techniques such as diffusion tensor imaging, quantitative susceptibility mapping, and magnetic transfer imaging have successfully emerged for the detection of micro-structural abnormalities. In the present review article, we provide a brief overview of Alzheimer's disease and explore recent neuroimaging developments in the field of dementia with an emphasis on structural MR imaging in order to propose a simple and easily applicable systematic approach to the imaging diagnosis of dementia.

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Overtime reliability of medial temporal lobe atrophy rating in a clinical setting

Abstract: Visual assessment of MTA repeated over time has a high grade of reproducibility when performed by an experienced investigator. The reproducibility drops when assessment is rarely performed. Inter-rater reliability is low when two investigators not working together are compared.

Cited by 36 publications

References 19 publications

Electroencephalography Is a Good Complement to Currently Established Dementia Biomarkers

Electroencephalography Is a Good Complement to Currently Established Dementia Biomarkers

Using visual rating to diagnose dementia: a critical evaluation of MRI atrophy scales

Structural MR Imaging in the Diagnosis of Alzheimer's Disease and Other Neurodegenerative Dementia: Current Imaging Approach and Future Perspectives

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