Overtime trend of thyroid hormones and thyroid autoimmunity and ovarian reserve: a longitudinal population study with a 12-year follow up

Bahri, Sara; Tehrani, Fahimeh Ramezani; Amouzgar, A; Rahmati, Maryam; Tohidi, Maryam; Vasheghani, Maryam; Azizi, Fereidoun

doi:10.1186/s12902-019-0370-7

Cited by 32 publications

(31 citation statements)

References 45 publications

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“…These conflicting results could be connected with the heterogeneity of the groups and with the fact that it was a retrospective study. On the other hand, in the longitudinal population study with 12 years of follow-up, it was observed that women with lower serum concentration of AMH had higher serum levels of TPOAbs at baseline with a tendency to increasing autoimmunity in comparison to women with better ovarian reserve status (43). As it was mentioned in the Introduction section, the serum concentration of AMH is considered as one of the most sensitive indicators of ovarian reserve; therefore, we can speculate based on the previous observation that the presence of TPOAbs in women with PCOS observed in our study could be connected with decreased fertility.…”

Section: Discussionmentioning

confidence: 98%

Ovarian Reserve and Serum Concentration of Thyroid Peroxidase Antibodies in Euthyroid Women With Different Polycystic Ovary Syndrome Phenotypes

et al. 2020

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Objective: It has been shown that women with polycystic ovary syndrome (PCOS), as well as Hashimoto's thyroiditis (HT), are characterized by increased incidence of infertility. Serum anti-Müllerian hormone (AMH), which reflects ovarian reserve, is elevated in PCOS women and is decreased in women with HT. The Rotterdam criteria recognize four clinical PCOS phenotypes, i.e., phenotypes A, B, C, and D. The aim of the present study was to investigate the relation between serum concentrations of thyroid peroxidase antibodies (TPOAbs) and ovarian reserve in different PCOS phenotypes. Patients and methods: We examined 141 women with PCOS [phenotype A was diagnosed in 67 (47.5%) women, phenotype B in 30 (21.3%), phenotype C in 28 (19.9%), and phenotype D in 16 (11.3%)] and 88 control subjects of similar age; all women were euthyroid. Serum concentrations of AMH, thyroid-stimulating hormone (TSH), thyroid hormones, and TPOAbs were assessed. Results: We observed positive serum TPOAbs in 21.9% women with PCOS and in 23.9% controls (p = 0.07). We did not find differences in the frequency of detection of positive serum TPOAbs between phenotypes A, B, and C and the control group (p > 0.05). We did not observe a difference in AMH levels between TPOAbs-positive and TPOAbs-negative women, both in the control group and the PCOS women (all p > 0.05). However, serum AMH concentration was markedly higher in the whole PCOS group (p < 0.01) and in phenotype A (p < 0.01) vs. controls when the serum concentration of TPOAbs was negative. In the groups with positive serum levels of TPOAbs, serum concentration of AMH did not differ between PCOS phenotypes and controls (p = 0.23). Additionally, we observed that serum AMH concentration was related to the level of TPOAbs in the PCOS group (r = −0.4, p = 0.02). Conclusions: The frequency of serum detection of positive TPOAbs did not differ between PCOS phenotypes with clinical/biochemical hyperandrogenism and the control Adamska et al. AMH and TPOAbs in PCOS Phenotypes group. The observation of the difference in serum AMH between the PCOS and control groups only in TPOAbs negative women together with the inverse relation of TPOAbs with serum AMH only in the PCOS group might suggest that ovarian reserve is influenced by TPOAbs in PCOS.

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Section: Discussionmentioning

confidence: 98%

Ovarian Reserve and Serum Concentration of Thyroid Peroxidase Antibodies in Euthyroid Women With Different Polycystic Ovary Syndrome Phenotypes

et al. 2020

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“…After adjustment for thyroid autoimmunity and age, TSH < 3.0 mIU/l in infertile euthyroid patients has been associated with significantly higher AMH than in patients with TSH ≥3.0 mIU/l [26]. Moreover, higher levels of thyroperoxidase antibodies (TPOAb) have been observed in women with a lower ovarian reserve, with a positive trend of these antibodies over time, indicating that this group may be at higher risk of hypothyroidism over time [27]. Kuroda et al [28] also reported a clear association between elevated TSH and reduced AMH levels.…”

Section: Discussionmentioning

confidence: 99%

Cross-sectional and prospective study on anti-Müllerian hormone changes in a cohort of pre-menopausal women with a history of differentiated thyroid cancer

et al. 2020

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Background: Anti-Müllerian hormone (AMH) decreases acutely after post-surgical radioactive iodine (RAI) ablation in females with differentiated thyroid cancer (DTC). Aim: We performed a cross-sectional and prospective study on AMH levels in pre-menopausal females with a history of DTC. Methods: Fifty-nine females after surgery and RAI (group 1) and 30 females after surgery alone (group 2) were studied. The control group consisted of 141 healthy women (group 3). The prospective study was performed in 43 and 14 females from groups 1 and 2, respectively. Results: On first evaluation, AMH levels were similar in groups 1 and 2, but lower than in group 3. In all groups, AMH was negatively related with chronological age and FSH levels. When subjects were stratified according to age, AMH levels were not different between groups. When AMH was evaluated up to 2 years after the baseline evaluation, no changes emerged in either group of women with DTC. In the prospective study, the incidence of abnormal menstrual cycles and the onset of menopause were observed in similar percentages of women with a history of RAI-treated DTC and of those treated with surgery alone. Conclusions: AMH can be considered a reliable index of ovarian reserve in women with DTC. Chronological age is the main factor influencing AMH levels in both DTC patients and controls. After age-related stratification, AMH levels are similar in women with DTC treated with RAI and those treated with surgery alone.

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“…Interestingly, none statistically relevant difference in circulating THs was detected at the baseline whereas the AbTPO antibodies concentration was higher in women included in Q1. A progressive decrease of fT4 and an increased level of AbTPO antibodies were detected in all the quartiles over time [ 93 ]. Accordingly, a previous study, involving about 1000 Chinese women, reported the increase of AbTPO antibodies concomitant with idiopathic DOR [ 94 ].…”

Section: Circulating Th/tsh Levels and Premature Ovarian Dysfunctimentioning

confidence: 99%

Thyroid Hormones and Functional Ovarian Reserve: Systemic vs. Peripheral Dysfunctions

Colella

Cuomo

Giacco

et al. 2020

JCM

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Thyroid hormones (THs) exert pleiotropic effects in different mammalian organs, including gonads. Genetic and non-genetic factors, such as ageing and environmental stressors (e.g., low-iodine intake, exposure to endocrine disruptors, etc.), can alter T4/T3 synthesis by the thyroid. In any case, peripheral T3, controlled by tissue-specific enzymes (deiodinases), receptors and transporters, ensures organ homeostasis. Conflicting reports suggest that both hypothyroidism and hyperthyroidism, assessed by mean of circulating T4, T3 and Thyroid-Stimulating Hormone (TSH), could affect the functionality of the ovarian reserve determining infertility. The relationship between ovarian T3 level and functional ovarian reserve (FOR) is poorly understood despite that the modifications of local T3 metabolism and signalling have been associated with dysfunctions of several organs. Here, we will summarize the current knowledge on the role of TH signalling and its crosstalk with other pathways in controlling the physiological and premature ovarian ageing and, finally, in preserving FOR. We will consider separately the reports describing the effects of circulating and local THs on the ovarian health to elucidate their role in ovarian dysfunctions.

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Overtime trend of thyroid hormones and thyroid autoimmunity and ovarian reserve: a longitudinal population study with a 12-year follow up

Cited by 32 publications

References 45 publications

Ovarian Reserve and Serum Concentration of Thyroid Peroxidase Antibodies in Euthyroid Women With Different Polycystic Ovary Syndrome Phenotypes

Ovarian Reserve and Serum Concentration of Thyroid Peroxidase Antibodies in Euthyroid Women With Different Polycystic Ovary Syndrome Phenotypes

Cross-sectional and prospective study on anti-Müllerian hormone changes in a cohort of pre-menopausal women with a history of differentiated thyroid cancer

Thyroid Hormones and Functional Ovarian Reserve: Systemic vs. Peripheral Dysfunctions

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