Overuse of diagnostic tools and medications in acute rhinosinusitis in Spain: a population-based study (the PROSINUS study)

Jaume, Francesca; Quintó, Llorenç; Alobid, Isam; Mullol, Joaquim

doi:10.1136/bmjopen-2017-018788

Cited by 60 publications

(60 citation statements)

References 55 publications

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“…Because the respiratory epithelium is the primary site of SARS-CoV-2 attachment and infection, as with many other respiratory viruses, it may not be surprising for COVID-19 to affect the olfactory neuro-epithelium having an impact on smell and flavour [42]. Recently, our team has demonstrated that two out of three patients with the common cold or postviral acute rhinosinusitis have impaired smell, this being associated with disease severity [16].…”

Section: Covid 19 and Olfactory Dysfunctionmentioning

confidence: 99%

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Olfactory Dysfunction in the COVID-19 Outbreak

Izquierdo-Domínguez¹,

Rojas-Lechuga²,

Mullol³

et al. 2020

J Investig Allergol Clin Immunol

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The first cases of coronavirus 2019 (COVID-19) occurred in Wuhan, China, and rapidly become a public health emergency of international proportions. The disease may cause mild-to-severe acute respiratory syndrome (SARS) and is caused by a SARS-CoV-2 coronavirus infection. The clinical manifestations of COVID-19 include fever, dry cough, fatigue, sputum production, shortness of breath, sore throat, and headache. This article is a narrative review with the aim of analyzing the current literature on postviral olfactory dysfunction (OD) related to SARS-CoV-2 pandemics. Since the initial anecdotal reports from China, international reports on COVID-19 patients have been increasing, describing a 5% to 85% range of loss of smell. To date, the literature is widely heterogeneous regarding the loss of smell; therefore, we advise home isolation measures and/or social distancing, and to carry out diagnostic tests for SARS-CoV-2 when possible in those patients with sudden and severe loss of smell who cannot be promptly evaluated.neurons nor the olfactory bulb neurons express specific genes that are instead expressed in support cells, stem cells, and perivascular cells. These findings suggest that infection of non-neuronal cell types leads to anosmia and related disturbances in odour perception in patients [7,8]

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Section: Covid 19 and Olfactory Dysfunctionmentioning

confidence: 99%

“…-Postviral upper respiratory infection could be due to a combined conductive and sensorineural/inflammatory disorder [16].…”

Section: Loss Of Smell Etiologymentioning

confidence: 99%

Olfactory Dysfunction in the COVID-19 Outbreak

Izquierdo-Domínguez¹,

Rojas-Lechuga²,

Mullol³

et al. 2020

J Investig Allergol Clin Immunol

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“…Odor detection is related to the most peripheral part of the olfactory system [ 7 ], whereas identification and recognition memory involve cognitive tasks of central structures, such as the orbitofrontal region and other areas of the limbic system. In addition to viral etiology [ 8 , 9 ], several other causal factors have been described: posttraumatic events [ 10 – 12 ], neurodegenerative diseases [ 13 – 15 ], sinonasal inflammatory diseases (chronic rhinosinusitis, nasal polyps) [ 16 – 19 ], and allergic rhinitis (in adults [ 20 ] or children) [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Olfactory Dysfunction in a Mexican Population Outside of COVID-19 Pandemic: Prevalence and Associated Factors (the OLFAMEX Study)

Castillo-López

Govea‐Camacho

Rodríguez-Torres

et al. 2020

Curr Allergy Asthma Rep

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Purpose of Review To study the prevalence of olfactory loss and its associated factors in a Mexican population a cross-sectional analytical study based on a population interviewed about health, epidemiologic aspects, and sense of smell (tested with four scents: rose, banana, perfume, and gas) was conducted to evaluate olfactory detection, memory, and identification. Levels of sense of smell perception were determined when the participants detected, recognized, or identified all (normosmia), 1–3 (hyposmia), or none (anosmia) of the odorants. Associated factors of olfactory dysfunction were identified by multivariate analysis (odds ratio, 95%CI). Recent Findings Olfactory dysfunction is a prevalent disorder affecting up to 20% of the general population. In addition to viral infection, including COVID-19, a number of other causes and factors may also be involved. Summary 1,956 surveys were conducted and 1,921 were analyzed. Most of the participants (62.1%) were women. The general prevalence of olfactory dysfunction, regarding detection, was 7.2% (7.1% hyposmia, 0.1% anosmia). Age-related olfactory deterioration was observed in both sexes from the 5th decade of life (OR 2.74, p = 0.0050). Women showed better olfactory identification (OR 0.73, p = 0.0010). Obesity (OR 1.97, p = 0.0070), low educational level, bad/very bad self-perceived olfactory function (OR 2.74, p = 0.0050), olfactory loss for less than one week (OR 1.35, p = 0.0030), exposure to toxics/irritants (OR 1.31, p = 0.0030), active smoking (OR 1.58, p < 0.0010), and type 2 diabetes mellitus (OR 2.68, 95%CI 1.74–4.10, p < 0.0001) were identified as factors associated with olfactory dysfunction. These results in a Mexican population suggest better olfactory identification (verbalization) in females. Age was a determining factor in the olfactory deterioration process and obesity and diabetes mellitus were also associated with olfactory disorders. Finally, these findings reinforce the differential diagnosis with other potential causes of sense of smell loss, during the COVID-19 outbreak.

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“…However, in ARS, the diagnosis is made on clinical grounds and CT is not recommended (191) unless the condition persists despite treatment or a complication is suspected, when contrast is used if there is no contraindication (223) . However, a recent study from Spain suggested that CT continues to be over-used in this context (224) .…”

Section: Recommendationsmentioning

confidence: 99%

European position paper on diagnostic tools in rhinology

Rimmer

Hellings

Lund

et al. 2019

Rhin

114

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is the official Journal of the European and International Rhinologic Societies and appears quarterly in March, June, September and December. Cited in Pubmed, Current Contents, Index Medicus, Exerpta Medica and Embase Founded in 1963 by H.A.E. van Dishoeck, Rhinology is a worldwide non-profit making journal. The journal publishes original papers on basic research as well as clinical studies in the major field of rhinology, including physiology, diagnostics, pathology, immunology, medical therapy and surgery of both the nose and paranasal sinuses. Review articles and short communications are also pulished. All papers are peer-reviewed. Letters-to-the-editor provide a forum for comments on published papers, and are not subject to editorial revision except for correction of English language. In-depth studies that are too long to be included into a regular issue can be published as a supplement. Supple ments are not subject to peer-review.

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Overuse of diagnostic tools and medications in acute rhinosinusitis in Spain: a population-based study (the PROSINUS study)

Cited by 60 publications

References 55 publications

Olfactory Dysfunction in the COVID-19 Outbreak

Olfactory Dysfunction in the COVID-19 Outbreak

Olfactory Dysfunction in a Mexican Population Outside of COVID-19 Pandemic: Prevalence and Associated Factors (the OLFAMEX Study)

European position paper on diagnostic tools in rhinology

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