Overview about Candida auris: What's up 12 years after its first description?

Désoubeaux, Guillaume; Coste, Alix T.; Imbert, Christophe; Hennequin, Christophe

doi:10.1016/j.mycmed.2022.101248

Cited by 24 publications

(22 citation statements)

References 137 publications

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“…Currently, the origin of C. auris is yet to be elucidated, with some speculating that global warming played a role in the selection of this species [ 7 8 9 ]. It is thus suggested that transmission was facilitated by animals with high body temperatures, such as birds, which could be responsible for spreading the fungus into urban areas, eventually infecting humans [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Candida auris: An Overview of the Emerging Drug-Resistant Fungal Infection

Sanyaolu

Okorie

Marinkovic³

et al. 2022

Infect Chemother

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Candida auris is an invasive fungal pathogen that has been recognized globally as a serious health threat due to its extensive innate and acquired resistance to antifungal drugs. A growing number of emerging cases of C. auris have been reported with resistance to the standard antifungal treatments including azoles, echinocandins, and polyenes, making it difficult to treat. Unlike other Candida species, C. auris is challenging to diagnose using the standard laboratory methods and are typically prone to misidentification, resulting in inappropriate management. Consequently, C. auris infections have spread globally. The Centers for Disease Control and Prevention data showed that clinical cases of C. auris increased from 329 in 2018 to 1,012 in 2021. The incidence and prevalence of this invasive fungal infection are high in immunocompromised and hospitalized patients. Patients who had an organ transplant, are on immunosuppressive agents, are diabetic, recent antibiotic use, catheter use, and prolonged hospital or nursing homestays are vulnerable to C. auris infections. C. auris is rapidly spreading across healthcare settings globally and monitoring of its virulence as well as devising appropriate treatment approaches are thus highly required.

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Section: Introductionmentioning

confidence: 99%

“…Furthermore, understanding how C. auris invades the epithelial layer without forming hyphae remains unclear. According to recent findings, C. auris isolates with a non-aggregative phenotype may be evading the immune system [ 7 10 11 12 ].…”

Section: Introductionmentioning

confidence: 99%

Candida auris: An Overview of the Emerging Drug-Resistant Fungal Infection

Sanyaolu

Okorie

Marinkovic³

et al. 2022

Infect Chemother

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“…Due to a slightly higher toxicity, Nys is used topically [ 37 , 38 , 39 , 40 ] to treat, for example, oral candidiasis [ 41 ]. Toxicity is a major problem when it comes to the clinical use of polyenes and remains an obstacle when addressing an increasing number of multidrug-resistant fungal pathogens such as Candida albicans , Candida lusitaniae [ 42 ], and Candida auris [ 43 ]. In addition to their function as therapeutic agents, polyenes have long been studied to understand all the phenomena they display at a molecular level and their effect on pharmacological action [ 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ].…”

Section: Introductionmentioning

confidence: 99%

Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications

et al. 2022

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This review examined a collection of studies regarding the molecular properties of some polyene antibiotic molecules as well as their properties in solution and in particular environmental conditions. We also looked into the proposed mechanism of action of polyenes, where membrane properties play a crucial role. Given the interest in polyene antibiotics as therapeutic agents, we looked into alternative ways of reducing their collateral toxicity, including semi-synthesis of derivatives and new formulations. We follow with studies on the role of membrane structure and, finally, recent developments regarding the most important clinical applications of these compounds.

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“…While Candida albicans remains the most common causative pathogen, there is an increasing incidence of candidemia caused by non- albicans species, with C. glabrata , C. tropicalis , C. parapsilosis , and C. krusei having a growing importance ( 3 ). During the past decade, Candida auris has emerged as a novel yeast species that is capable of causing major outbreaks and is associated with a high level of resistance toward commonly used antifungals ( 4 ). Therefore, rapid and reliable identification of the causative pathogen is of major importance for guiding therapeutic choices.…”

Section: Introductionmentioning

confidence: 99%