Overview and status of bottom-up silicon nanowire electronics

Silicon nanowire (SiNW) field-effect transistor (FET) biosensors have already been used as powerful sensors for the direct detection of disease-related biomarkers. However, the multiplexed detection of biomarkers in real samples is still challenging. Interleukin 8 (IL-8) and tumor necrosis factor α (TNF-α) are two typical biomarkers of oral squamous cell carcinoma (OSCC). In this study, we developed a multiplexed detection methodology for IL-8 and TNF-α detection in saliva using SiNW FET biosensors. We fabricated the SiNW FET sensors using a top-down lithography fabrication technique. Subsequently, we achieved the multiplexed detection of two biomarkers in saliva by specific recognition of the two biomarkers with their corresponding antibodies, which were modified on the SiNW. The established method was found to have a limit of detection as low as 10 fg/mL in 1×PBS as well as 100 fg/mL in artificial saliva. Because of its advantages, including label-free and multiplexed detection, non-invasive analysis, highly sensitive and specific determination, the proposed method is expected to be widely used for the early diagnosis of OSCC.

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“…32,33 The bottom-up fabrication is simple and cost-effective. However, it has difficulties concerning position and shape control.…”

Section: Introductionmentioning

confidence: 99%

Silicon Nanowire Biosensor for Highly Sensitive and Multiplexed Detection of Oral Squamous Cell Carcinoma Biomarkers in Saliva

Zhang

Rong-mei

et al. 2015

ANAL. SCI.

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“…SiNW [38]. Although SiNW FETs present ultra-sensitive and label-free electrical detection of biomolecules in real-time, less consideration on biological multiplexing is less given due to the greater focus of current research on the production and analysis of FET devices.…”

Section: Silicon Nanowirementioning

confidence: 99%

Progression in sensing cardiac troponin biomarker charge transductions on semiconducting nanomaterials

Fathil

Arshad

Ruslinda

et al. 2016

Analytica Chimica Acta

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“…For miniaturised biosensors Si nanowires boast excellent electrical and mechanical properties which, combined with their high surface area to volume ratio, make them attractive candidates for applications such as field effect transistors (FETs) [18,19] and sensing devices [20,21]. Research into the use of SiNWs as FET-type sensors began by using chemically grown NWs [20].…”

Section: Background To the Nanowire-enabled Sinaps Motementioning

confidence: 99%

A miniaturised autonomous sensor based on nanowire materials platform: the SiNAPS mote

et al. 2013

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Author(s)Koshro Pour, Naser; Kayal, M.; Jia, G. is set up to detect hydrogen gas concentration in the low ppm range and over a broad temperature range using a low power sensing interface circuit. Using Telran TZ1053 radio to send one sample measurement of both temperature and H 2 concentration every 15 seconds, the average and active power consumption for the SiNAPS mote are less than 350nW and 2.1 µW respectively. Low-power miniaturised chemical sensors of liquid analytes through microfluidic delivery to silicon nanowires are also presented. These components demonstrate the potential of further miniaturization and application of sensor nodes beyond the typical physical sensors, and are enabled by the nanowire materials platform.

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Overview and status of bottom-up silicon nanowire electronics

Cited by 32 publications

References 127 publications

Silicon Nanowire Biosensor for Highly Sensitive and Multiplexed Detection of Oral Squamous Cell Carcinoma Biomarkers in Saliva

Silicon Nanowire Biosensor for Highly Sensitive and Multiplexed Detection of Oral Squamous Cell Carcinoma Biomarkers in Saliva

Progression in sensing cardiac troponin biomarker charge transductions on semiconducting nanomaterials

A miniaturised autonomous sensor based on nanowire materials platform: the SiNAPS mote

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