Overview of animal test methods for skin irritation

Gfeller, W.; Kobel, Werner; Seifert, G.

doi:10.1016/0278-6915(85)90009-2

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Skin Irritation Studies4

Introduction1

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2024

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Cited by 40 publications

(14 citation statements)

References 6 publications

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“…The method of Gfeller et al (1985) was used on rats to determine acute skin irritation of Leea macrophylla extract bioadhesive gel. 500 mm 2 area of dorsal hair of animals were shaved and cleaned.…”

Section: Acute Skin Irritation Testmentioning

confidence: 99%

Systematic investigation of ethanolic extract from Leea macrophylla : Implications in wound healing

Joshi

Pandey

et al. 2016

Journal of Ethnopharmacology

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Section: Acute Skin Irritation Testmentioning

confidence: 99%

Systematic investigation of ethanolic extract from Leea macrophylla : Implications in wound healing

Joshi

Pandey

et al. 2016

Journal of Ethnopharmacology

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“…This was carried out by the method of Gfeller et al (1985) on rats. About 500 mm 2 area on the dorsal fur of each animal was shaved.…”

Section: Acute Skin Irritation Testmentioning

confidence: 99%

Evaluation of the wound healing activity of methanol extract of Pedilanthus tithymaloides (L.) Poit leaf and its isolated active constituents in topical formulation

Ghosh

Samanta

Mandal

et al. 2012

Journal of Ethnopharmacology

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“…The rabbit 13 was shaved the skin in three different position of dorsal side, each about 500mm 2 . The rabbit was kept in rabbit holder and the 1 st area was kept as control, to which vehicle was applied.…”

Section: Skin Irritation Studiesmentioning

confidence: 99%

Wound Healing Activity of Alcoholic Extract of Solanum Erianthum D.DON in Excision and Incision Method

Bhargavi¹,

Swamy²,

Bilal³

et al. 2013

Int. J. Res. Ayur. Pharm.

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Solanum erianthum D. Don is an unarmed shrub or small tree with dense indumentums of soft stellate hairs. Leaves are simple, ovate-elliptical; margin entire or slight wavy, base rounded to cuneate, and apex acute to acuminate. The leaves have been extensively used for leucorrhoea, piles, hemorrhoids, scrofula, headache, vertigo, digestive troubles and for wound healing purposes. Wistar albino rats of either sex weighing between 200 and 220g were topically treated with extract formulated in gel (10% and 20%) which was applied once daily in excision and incision wound model. Rats of standard groups were treated with 5% w/w Povidone-Iodine ointment topically. The percentage of wound contraction was increased, epithelization period was decreased and wound breaking strength was increased with topical application of AESE (Alcoholic Extract of Solanum erianthum) gel in excision and incision wound model. The experimental data revealed that the AESE displayed remarkable wound healing activity thus supports its traditional use.

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Overview of animal test methods for skin irritation

Cited by 40 publications

References 6 publications

Systematic investigation of ethanolic extract from Leea macrophylla : Implications in wound healing

Systematic investigation of ethanolic extract from Leea macrophylla : Implications in wound healing

Evaluation of the wound healing activity of methanol extract of Pedilanthus tithymaloides (L.) Poit leaf and its isolated active constituents in topical formulation

Wound Healing Activity of Alcoholic Extract of Solanum Erianthum D.DON in Excision and Incision Method

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