Overview of Antibacterial Strategies of Dental Implant Materials for the Prevention of Peri-Implantitis

Chen, Zehao; Wang, Zhaodan; Qiu, Wei; Fang, Fuchun

doi:10.1021/acs.bioconjchem.1c00129

Cited by 54 publications

(57 citation statements)

References 124 publications

(196 reference statements)

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“…Peri-implant diseases are biological complications of dental implantation which are mainly caused by microbial bio lm [42,43]. To handle the challenge of peri-implant diseases, it is essential to improve the antimicrobial properties of dental implants [44]. Recent studies demonstrated that the antibacterial properties of the materials can be improved by the construction of nanostructured surfaces [45,46].…”

Section: Discussionmentioning

confidence: 99%

Multi-Omics Analysis of Oral Bacterial Biofilm on Titanium Oxide Nanostructure Modified Implant Surface: in Vivo Sequencing-Based Pilot Study in Beagle Dogs

Sun¹,

Chan

et al. 2021

Preprint

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Background and aimsSurface modifications of titanium implants play essential role in facilitating osteointegration and enhancing their antimicrobial properties, while the latter is critical for preventing infectious diseases caused by the biofilm. However, it remains unknown about how the surface modifications could affect the composition and functional gene expression of oral microbiota deposited on the titanium implants. In this study, we aimed to investigate the impact of different nanostructured surfaces on the biofilm in vivo.ResultsNanophase calcium phosphate were successfully deposited into or between the TiO2 nanotubes with a diameter of 70–90 nm. NT and NTN surfaces showed increased roughness than the MP surface. XPS spectra showed that the O 1s was mainly divided into two bands in MP and NT samples, including Ti-O and -OH, while the surface modification of TiO2 nanotube in NT accounted for the increased intensity of Ti-O with the reference to that in MP samples. After the deposition of calcium phosphate, two new elemental peaks of Ca and P can be identified from the XPS survey spectrum of NTN. Moreover, the O 1s of NTN sample could be differentiated into three peaks, while the new one represented the -PO band. The 16S rDNA sequencing results showed that NT and NTN had minimal impact on the diversity and community structure of oral microbiota. Metatranscriptomic sequencing revealed that differentially expressed genes (DEGs) mostly differed in the terms of the biological process and cellular component on different surfaces. Gene Ontology (GO) terms enrichment indicated that NTN down-regulate the genes associated in localization and locomotion. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that the DEGs were associated with microbial metabolism, protein synthesis and bacterial invasion of epithelial cells.ConclusionTiO2 nanotube and calcium phosphate-coated TiO2 nanotube despite improving the antimicrobial properties of implant surfaces, had unexpectedly minimal impact on the microbiome composition and diversity. Notably, nanostructured titanium surfaces could inhibit the bacterial migration and colonization, down-regulate the pathogen invasion pathways, and further destruct bacterial cellular membrane, all in all, conferred the bactericidal properties.

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Section: Discussionmentioning

confidence: 99%

Multi-Omics Analysis of Oral Bacterial Biofilm on Titanium Oxide Nanostructure Modified Implant Surface: in Vivo Sequencing-Based Pilot Study in Beagle Dogs

Sun¹,

Chan

et al. 2021

Preprint

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“…Tooth loss is another common dental disease. Nowadays, biologically inactive dental implants have become the most commonly used method for teeth restoration [ 31 ]. There is no periodontal connection built between implants and alveolar bone, leading to disability of distributing chewing pressure and failed feeling changes in temperature or pressure because of a lack of pulp tissue.…”

Section: Dpsc Sheets Applicationsmentioning

confidence: 99%

“…With the wide application of titanium implants in the restoration of missing teeth, increasing attention has been given to peri-implant inflammation. Without timely intervention, it will lead to rapid progression of inflammation, bone destruction, and ultimately failure of implant surgery [ 31 ]. One of the strategies of peri-implantitis regeneration therapy is cell sheet technology.…”

Section: Pdlsc Sheets Applicationsmentioning

confidence: 99%

Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine

Chen

Huang

et al. 2022

Stem Cell Res Ther

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Stem cells transplantation is the main method of tissue engineering regeneration treatment, the viability and therapeutic efficiency are limited. Scaffold materials also play an important role in tissue engineering, whereas there are still many limitations, such as rejection and toxic side effects caused by scaffold materials. Cell sheet engineering is a scaffold-free tissue technology, which avoids the side effects of traditional scaffolds and maximizes the function of stem cells. It is increasingly being used in the field of tissue regenerative medicine. Dental-derived mesenchymal stem cells (DMSCs) are multipotent cells that exist in various dental tissues and can be used in stem cell-based therapy, which is impactful in regenerative medicine. Emerging evidences show that cell sheets derived from DMSCs have better effects in the field of regenerative medicine applications. Extracellular matrix (ECM) is the main component of cell sheets, which is a dynamic repository of signalling biological molecules and has a variety of biological functions and may play an important role in the application of cell sheets. In this review, we summarized the application status, mechanisms that sheets and ECM may play and future prospect of DMSC sheets on regeneration medicine.

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“…The polymers create a hydrated layer on the surface that reduces protein adsorption. The effect varies according to the length of the polymer chains, and the uniformity and density of the polymer [ 81 ].…”

Section: Structural Enhancements and Experimental Designsmentioning

confidence: 99%

Microbial Decontamination and Antibacterial Activity of Nanostructured Titanium Dental Implants: A Narrative Review

et al. 2021

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Peri-implantitis is the major cause of the failure of dental implants. Since dental implants have become one of the main therapies for teeth loss, the number of patients with peri-implant diseases has been rising. Like the periodontal diseases that affect the supporting tissues of the teeth, peri-implant diseases are also associated with the formation of dental plaque biofilm, and resulting inflammation and destruction of the gingival tissues and bone. Treatments for peri-implantitis are focused on reducing the bacterial load in the pocket around the implant, and in decontaminating surfaces once bacteria have been detached. Recently, nanoengineered titanium dental implants have been introduced to improve osteointegration and provide an osteoconductive surface; however, the increased surface roughness raises issues of biofilm formation and more challenging decontamination of the implant surface. This paper reviews treatment modalities that are carried out to eliminate bacterial biofilms and slow their regrowth in terms of their advantages and disadvantages when used on titanium dental implant surfaces with nanoscale features. Such decontamination methods include physical debridement, chemo-mechanical treatments, laser ablation and photodynamic therapy, and electrochemical processes. There is a consensus that the efficient removal of the biofilm supplemented by chemical debridement and full access to the pocket is essential for treating peri-implantitis in clinical settings. Moreover, there is the potential to create ideal nano-modified titanium implants which exert antimicrobial actions and inhibit biofilm formation. Methods to achieve this include structural and surface changes via chemical and physical processes that alter the surface morphology and confer antibacterial properties. These have shown promise in preclinical investigations.

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Overview of Antibacterial Strategies of Dental Implant Materials for the Prevention of Peri-Implantitis

Cited by 54 publications

References 124 publications

Multi-Omics Analysis of Oral Bacterial Biofilm on Titanium Oxide Nanostructure Modified Implant Surface: in Vivo Sequencing-Based Pilot Study in Beagle Dogs

Multi-Omics Analysis of Oral Bacterial Biofilm on Titanium Oxide Nanostructure Modified Implant Surface: in Vivo Sequencing-Based Pilot Study in Beagle Dogs

Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine

Microbial Decontamination and Antibacterial Activity of Nanostructured Titanium Dental Implants: A Narrative Review

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