Overview of autoimmune liver disease: Prevalence, risk factors, and role of autoantibodies

Dong, Xiaoli; Lin, Henry C.; Shah, Ankur

doi:10.1002/cld.1227

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…In White North American adults, 80% had ANA, 63% SMA, and 3% anti-LKM-1 at presentation, with 51% having multiple autoantibodies. Detecting two autoantibodies improved diagnostic accuracy from 58 to 74% [ 21 ]. Pediatric studies show varied antibody positivity (ANA: 30%–100%) [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Retrospective, single-center analysis of autoimmune hepatitis in Jordanian children: clinical features, treatments, and outcomes

Altamimi,

Al Omari,

Obeidat

et al. 2024

BMC Pediatr

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Objectives This study describes clinical, biochemical, and histological features and long-term outcomes in pediatric patients diagnosed with autoimmune hepatitis (AIH) at King Abdullah University Hospital, Jordan. Design Retrospective, single-center study. Setting King Abdullah University Hospital, Jordan. Participants Inclusion of all pediatric patients with AIH diagnosed at our hospital from 2015 to 2023. Exclusion criteria was patients aged over 18 at time of diagnosis and those diagnosed elsewhere. Outcome measures Understanding clinical, biochemical, and histological AIH features in children, evaluating treatment responses, and reporting short- and long-term complications, including mortality. Results Sixteen pediatric cases were diagnosed, with an average age of 9.84 ± 4.13 years. Females comprised 75% of patients, and 31.3% presented with acute liver failure. Jaundice was the most common symptom, and hepatosplenomegaly was observed in 18% of cases. Most patients had elevated transaminase levels, along with positive anti-smooth muscle antibody (ASMA) and antinuclear antibodies (ANA). Common hematological abnormalities included anemia (56.3%) and thrombocytopenia (37.5%). All patients underwent liver biopsy, with interface hepatitis present in 81.3% of cases. Treatment mainly involved prednisone and azathioprine. Three patients died, one discontinued therapy, two patients were lost to follow-up, and 10 remained on treatment. Conclusion Autoimmune hepatitis affects Jordanian children, primarily female children. Jaundice is the most common presenting symptoms. Only Type I AIH occurred in our cohort. Although of good response to conventional treatment with steroids and immunosuppression, mortality reached 18.8%.

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Section: Discussionmentioning

confidence: 99%

Retrospective, single-center analysis of autoimmune hepatitis in Jordanian children: clinical features, treatments, and outcomes

Altamimi,

Al Omari,

Obeidat

et al. 2024

BMC Pediatr

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Autoimmune Diseases: Recent Insights on Epidemiology, Pathogenesis, and Prevalence Rate

Nautiyal,

Sharma,

Pandey

et al. 2024

Studies in Computational Intelligence

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Overview of autoimmune liver disease: Prevalence, risk factors, and role of autoantibodies

Abstract: Answer questions and earn https://www.wileyhealthlearning.com/#/online-courses/110bfe98-3cfa-44f1-a819-fe56dec54d54 Content available: Author Interview and Audio Recording

Cited by 2 publications

References 23 publications

Retrospective, single-center analysis of autoimmune hepatitis in Jordanian children: clinical features, treatments, and outcomes

Retrospective, single-center analysis of autoimmune hepatitis in Jordanian children: clinical features, treatments, and outcomes

Autoimmune Diseases: Recent Insights on Epidemiology, Pathogenesis, and Prevalence Rate

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