Overview of cationic phthalocyanines for effective photoinactivation of pathogenic microorganisms

Ribeiro, Cláudia P.S.; Lourenço, Leandro M. O.

doi:10.1016/j.jphotochemrev.2021.100422

Cited by 45 publications

(22 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A variety of macrocycles derived from porphyrins, chlorines, bacteriochlorins, and phthalocyanines have been proposed as potential phototherapeutic agents [3][4][5]. In particular, the use of porphyrins have three main advantages: high absorption in the visible area of the spectrum, chemical stability due to their aromatic structure, and low toxicity in the dark.…”

Section: Introductionmentioning

confidence: 99%

Porphyrin–Schiff Base Conjugates Bearing Basic Amino Groups as Antimicrobial Phototherapeutic Agents

et al. 2021

View full text Add to dashboard Cite

New porphyrin–Schiff base conjugates bearing one (6) and two (7) basic amino groups were synthesized by condensation between tetrapyrrolic macrocycle-containing amine functions and 4-(3-(N,N-dimethylamino)propoxy)benzaldehyde. This approach allowed us to easily obtain porphyrins substituted by positive charge precursor groups in aqueous media. These compounds showed the typical Soret and four Q absorption bands with red fluorescence emission (ΦF ~ 0.12) in N,N-dimethylformamide. Porphyrins 6 and 7 photosensitized the generation of O2(1Δg) (ΦΔ ~ 0.44) and the photo-oxidation of L-tryptophan. The decomposition of this amino acid was mainly mediated by a type II photoprocess. Moreover, the addition of KI strongly quenched the photodynamic action through a reaction with O2(1Δg) to produce iodine. The photodynamic inactivation capacity induced by porphyrins 6 and 7 was evaluated in Staphylococcus aureus, Escherichia coli, and Candida albicans. Furthermore, the photoinactivation of these microorganisms was improved using potentiation with iodide anions. These porphyrins containing basic aliphatic amino groups can be protonated in biological systems, which provides an amphiphilic character to the tetrapyrrolic macrocycle. This effect allows one to increase the interaction with the cell wall, thus improving photocytotoxic activity against microorganisms.

show abstract

Section: Introductionmentioning

confidence: 99%

Porphyrin–Schiff Base Conjugates Bearing Basic Amino Groups as Antimicrobial Phototherapeutic Agents

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The fast development of drug resistance towards the variety of antibiotics features the emergency need of an effective approach, such as PDT, to keep harmful pathogens under control [ 28 , 29 ]. Previous studies to inactivate the drug-resistant A. hydrophila, which is a ubiquitous Gram-negative bacterium causing diseases in reptiles, amphibians, farm fish, and humans, showed that the drinking water isolate of this bacterium, as well as the native counterparts, are liable to PDT treatment with cationic phthalocyanine complexes, with different hydrocarbon chains as substituents [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Inactivation of Antibiotic-Resistant and Sensitive Aeromonas hydrophila with Peripheral Pd(II)- vs. Zn(II)-Phthalocyanines

Mantareva

Kussovski

Orozova³

et al. 2022

Biomedicines

View full text Add to dashboard Cite

The antimicrobial multidrug resistance (AMR) of pathogenic bacteria towards currently used antibiotics has a remarkable impact on the quality and prolongation of human lives. An effective strategy to fight AMR is the method PhotoDynamic Therapy (PDT). PDT is based on a joint action of a photosensitizer, oxygen, and light within a specific spectrum. This results in the generation of singlet oxygen and other reactive oxygen species that can inactivate the pathogenic cells without further regrowth. This study presents the efficacy of a new Pd(II)- versus Zn(II)-phthalocyanine complexes with peripheral positions of methylpyridiloxy substitution groups (pPdPc and ZnPcMe) towards Gram-negative bacteria Aeromonas hydrophila (A. hydrophila). Zn(II)-phthalocyanine, ZnPcMe was used as a reference compound for in vitro studies, bacause it is well-known with a high photodynamic inactivation ability for different pathogenic microorganisms. The studied new isolates of A. hydrophila were antibiotic-resistant (R) and sensitive (S) strains. The photoinactivation results showed a full effect with 8 µM pPdPc for S strain and with 5 µM ZnPcMe for both R and S strains. Comparison between both new isolates of A. hydrophila (S and R) suggests that the uptakes and more likely photoinactivation efficacy of the applied phthalocyanines are independent of the drug sensitivity of the studied strains.

show abstract

“…Porphyrins are not the only PSs aimed for the inactivation of bacteria. Phthalocyanines are widely used against bacteria proliferation, with comprehensive reviews being recently published by Galstyan [48] and by Ribeiro [49] . In the present section we aim to present some of the most representative advances on the use of phthalocyanines against Gramnegative growth.…”

Section: Cationic Phthalocyanines and Subphthalocyaninesmentioning

confidence: 99%

Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer’s structure and delivery systems

Maldonado-Carmona

Ouk

Leroy‐Lhez

2021

Photochem Photobiol Sci

View full text Add to dashboard Cite

Overview of cationic phthalocyanines for effective photoinactivation of pathogenic microorganisms

Cited by 45 publications

References 75 publications

Porphyrin–Schiff Base Conjugates Bearing Basic Amino Groups as Antimicrobial Phototherapeutic Agents

Porphyrin–Schiff Base Conjugates Bearing Basic Amino Groups as Antimicrobial Phototherapeutic Agents

Photodynamic Inactivation of Antibiotic-Resistant and Sensitive Aeromonas hydrophila with Peripheral Pd(II)- vs. Zn(II)-Phthalocyanines

Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer’s structure and delivery systems

Contact Info

Product

Resources

About