Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence

Savvateeva, Lyudmila V.; Erdes, S.I.; Antishin, A.S.; Zamyatnin, Andrey A.

doi:10.1155/2017/2314813

Cited by 19 publications

(21 citation statements)

References 42 publications

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“…At present, the global CD prevalence is estimated at approximately 1% with a clear tendency to increase based on data from various locations [15-17]. This lifelong disorder should be identified promptly, but the availability of screening strategies for CD is debatable.…”

Section: Introductionmentioning

confidence: 99%

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

Savvateeva

Erdes

Antishin

et al. 2018

Int Arch Allergy Immunol

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Coeliac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten-containing grains in genetically predisposed individuals. Identification of CD in clinical practice is often difficult due to the manifestation of non-specific symptoms and signs, so a relatively significant proportion of CD cases remain undiagnosed. Timely detection of the disease is necessary to provide an appropriate approach to control of the disease treatment, in order to avoid potential complications. This is even more important in the case of children and adolescents, to ensure their proper growth and development. In this review, we discuss the data on the current strategies for CD detection among paediatric populations and the role of questionnaire-based discovery of CD cases in the area of interest. We assume that mass screening is a preferable strategy for finding CD cases within the paediatric population because this could uncover symptomatic, oligosymptomatic, and asymptomatic CD cases. However, under conditions of limited financial resources, screening for CD in risk groups, members of which can be identified using questionnaires, is essential. The pros and cons of CD screening in paediatric populations are presented. These depend on a number of situational criteria (cost-effectiveness, lack of awareness), but screening is designed to improve the detection of the disease and therefore improve the quality of life of patients.

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Section: Introductionmentioning

confidence: 99%

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

Savvateeva

Erdes

Antishin

et al. 2018

Int Arch Allergy Immunol

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“…Previous reports from North Jordan also documented female predominance. Still, male predominance was reported in Pakistani children and in children in some areas of the Russian federation [ 9 10 ].…”

Section: Discussionmentioning

confidence: 99%

Celiac Disease in South Jordan

Altamimi

2017

Pediatr Gastroenterol Hepatol Nutr

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PurposeCeliac disease, an autoimmune enteropathy triggered by exposure to gluten, is not uncommon in South Jordan. However, its prevalence is underestimated due to lack of physician awareness of the diversity of disease presentation. The clinical spectrum includes classic gastrointestinal manifestations, as well as rickets, iron-deficiency anemia, short stature, elevated liver enzymes, and edema. Our goal was to evaluate celiac disease presentation in clinically diagnosed children.MethodsRetrospective study included all children diagnosed with celiac disease between September 2009 and September 2015. Hospital charts were reviewed. Demographic data, clinical characteristics, and follow-up were recorded.ResultsThirty-five children were diagnosed with celiac disease during the study period. Mean age±standard deviation was 6.7±3.8 years (range, 2.0–14 years). There were 17 (48.6%) female patients. The average duration between onset of symptoms and diagnosis was 16.3±18.7 months. Fifteen (42.9%) patients presented with classic malabsorption symptoms, whereas 7 (20.0%) patients presented with short stature. Positive tissue transglutaminase antibodies (tTg)-immunoglobulin A (IgA) was seen in 34 (97.1%) patients. The one patient with negative tTg-IgA had IgA deficiency. Although tTG-IgA values were not available for objective documentation of compliance, clinical data (resolution of presenting abnormalities and growth improvement) assured acceptable compliance in 22 (62.9%) patients.ConclusionCD in children may present with diverse picture. Although of the small number, the non-classical presentations are not uncommon in our rural community. Gluten-free diet is the main strategy for treatment and associated with usually correction of laboratory abnormalities and improvement of growth.

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“…Additionally, Savvateeva et al reported data on the polymorphic variants of HLA-DQA1 and -DQB1 genes in CD patients from the cities of Tomsk and Krasnodar (which are located in Russia, north and west of Kazakhstan respectively) and from Yakutia (Eastern Russia). These studies (all published in Russian) suggested that the allelic frequencies of CD-related HLA-DQ genes in those populations may be comparable to those observed in Europe [35].…”

Section: Central Asiamentioning

confidence: 95%

“…However, a paper by Savvateeva et al first provided an overview on CD in Russia and, interestingly, also cited some references of studies coming from the surrounding republics of Central Asia [35]. Therefore, some more information about CD in Central Asia could be obtained from Russian-language medical sources.…”

Section: Central Asiamentioning

confidence: 99%

Pediatric Celiac Disease in Central and East Asia: Current Knowledge and Prevalence

Poddighe

Rakhimzhanova

Marchenko³

et al. 2019

Medicina

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The current prevalence of pediatric Celiac Disease (CD) is estimated to be around 1% in the general population, worldwide. However, according to the geographic area, a great variability of CD prevalence has been described. Whereas a number of studies are available from Europe, North and South America, Australia, South-West Asia, and North Africa, the knowledge and awareness of CD in large parts of the remaining world areas is definitively poor. In several countries of Central and East Asia, the consumption of wheat is consistent and/or has significantly increased in recent decades, and CD is supposed to be underdiagnosed in children. In this mini-review, we aimed to summarize the current knowledge about the prevalence of pediatric CD in Central and East Asia, paying attention to the HLA-DQ immunogenetic background as well. Indeed, CD is likely not to be as uncommon as previously or currently thought in countries like Russia, Kazakhstan, and China, in addition to India, where pediatric CD has been clearly showed to be quite prevalent. Therefore, there is an urgent need for population-based studies on the prevalence of CD in those countries, especially in children, in order to increase the awareness of this disease and to improve the diagnostic strategy in these areas.

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Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence

Cited by 19 publications

References 42 publications

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

Celiac Disease in South Jordan

Pediatric Celiac Disease in Central and East Asia: Current Knowledge and Prevalence

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