Overview of Early Detection of Gastrointestinal Cancer

Pola, Sudhakar; Sanapala, Pavani; Naidu, B. Pratap

doi:10.1007/978-981-15-4431-6_8

Cited by 2 publications

(3 citation statements)

References 58 publications

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“…Several meta-analyses have demonstrated an association between the presence of GC CTCs and advanced tumor stage, lymphatic invasion, and poorer survival [ 29 ]. There are various markers for gastric cancer CTCs; for the epithelial subtype, they include EpCAm, cytokeratin (CK): CK8, CK18, and CK19 and for the mesenchymal subtype, they include vimentin and twist [ 30 , 31 ]. Another interesting marker for gastric cancer CTCs is fluorescence in situ hybridization (FISH) detection of CTCs with chromosome 8 aneuploidy, a mutation commonly found in gastric tumor cells [ 32 ].…”

Section: Diagnosismentioning

confidence: 99%

Recent Trends and Advancements in the Diagnosis and Management of Gastric Cancer

Haque

Esmail

Muhsen

et al. 2022

Cancers

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Gastric cancer is an enigmatic malignancy that has recently been shown to be increasing in incidence globally. There has been recent progress in emerging technologies for the diagnosis and treatment of the disease. Improvements in non-invasive diagnostic techniques with serological tests and biomarkers have led to decreased use of invasive procedures such as endoscopy. A multidisciplinary approach is used to treat gastric cancer, with recent significant advancements in systemic therapies used in combination with cytotoxic chemotherapies. New therapeutic targets have been identified and clinical trials are taking place to assess their efficacy and safety. In this review, we provide an overview of the current and emerging treatment strategies and diagnostic techniques for gastric cancer.

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Section: Diagnosismentioning

confidence: 99%

Recent Trends and Advancements in the Diagnosis and Management of Gastric Cancer

Haque

Esmail

Muhsen

et al. 2022

Cancers

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show abstract

“…Although various treatment strategies can be applied [19], the overall survival rate remains low in advanced disease stages, presenting an urgent need for new diagnostic and therapeutic markers [20].…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the number of patients suffering from GI cancers has gradually increased (about 5 million patients in 2018), resulting in a higher mortality rate (approximately 3.5 million), which makes these malignancies a major cause of cancer‐related deaths worldwide [18]. Although various treatment strategies can be applied [19], the overall survival rate remains low in advanced disease stages, presenting an urgent need for new diagnostic and therapeutic markers [20].…”

Section: Introductionmentioning

confidence: 99%

Functional role of lncRNAs in gastrointestinal malignancies: the peculiar case of small nucleolar RNA host gene family

2022

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Long noncoding RNAs (lncRNAs) play crucial roles in normal physiology and are often de-regulated in disease states such as cancer. Recently, a class of lncRNAs referred to as the small nucleolar RNA host gene (SNHG) family have emerged as important players in tumourigenesis. Here, we discuss new findings describing the role of SNHGs in gastrointestinal tumours and summarize the three main functions by which these lncRNAs promote carcinogenesis, namely: competing with endogenous RNAs, modulating protein function, and regulating epigenetic marking. Furthermore, we discuss how SNHGs participate in different hallmarks of cancer, and how this class of lncRNAs may serve as potential biomarkers in cancer diagnosis and therapy.

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Overview of Early Detection of Gastrointestinal Cancer

Cited by 2 publications

References 58 publications

Recent Trends and Advancements in the Diagnosis and Management of Gastric Cancer

Recent Trends and Advancements in the Diagnosis and Management of Gastric Cancer

Functional role of lncRNAs in gastrointestinal malignancies: the peculiar case of small nucleolar RNA host gene family

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