This article characterizes the spacecraft as a means of performing various tasks, including by precision equipment. Emphasis is placed on vibration as one of the influencing factors and on the need for a low level of vibration on the spacecraft. Among the side effects of the electric pump unit of the thermal control system, the urgent task is to reduce vibration activity when developing a new model for advanced spacecraft. An integrated approach to solving the problem is indicated with the consideration of electric pump unit as a system and the selection of several directions to achieve the root-mean square value of vibration acceleration of 0,01g and below. Possible methods for reducing vibration activity in each of the directions and implemented solutions in the developed sample are described in detail. On several versions of electric pump unit for experimental determination of the level of root-mean square value vibration acceleration at a frequency of 5–1000 Hz. According to the results of the experiment, the contribution to the reduction of vibroactivity in several directions is estimated. It is concluded that only an integrated approach makes it possible to achieve a very low level of vibration activity of electric pump unit.