Overview of Electrospinned Chitosan Nanofiber Composites for Wound Dressings

Vega-Cázarez, Claudia A.; Sánchez‐Machado, Dalia I.; JaimeLópez-Cervantes,

doi:10.5772/intechopen.76037

Cited by 12 publications

(10 citation statements)

References 91 publications

(152 reference statements)

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“…Nevertheless, the polycationic nature and rigid chemical structure of chitosan limits its electrospinnability. The formation of nanofibers is facilitated by blending chitosan with another polymer, thereby allowing the formation of hydrogen bonds (Cázarez et al, 2018). Chitosan has been combined with PEO, poly (lactic-co-glycolic acid) (PLGA), and polyacrylamide to form nanofibers, which have served as delivery systems, respectively, for Bacillus sp.…”

Section: Polymers Natural Polymersmentioning

confidence: 99%

Electrospun Nanofibers as Carriers of Microorganisms, Stem Cells, Proteins, and Nucleic Acids in Therapeutic and Other Applications

Stojanov

Berlec

2020

Front. Bioeng. Biotechnol.

129

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Electrospinning is a technique that uses polymer solutions and strong electric fields to produce nano-sized fibers that have wide-ranging applications. We present here an overview of the use of electrospinning to incorporate biological products into nanofibers, including microorganisms, cells, proteins, and nucleic acids. Although the conditions used during electrospinning limit the already problematic viability/stability of such biological products, their effective incorporation into nanofibers has been shown to be feasible. Synthetic polymers have been more frequently applied to make nanofibers than natural polymers. Polymer blends are commonly used to achieve favorable physical properties of nanofibers. The majority of nanofibers that contain biological product have been designed for therapeutic applications. The incorporation of these biological products into nanofibers can promote their stability or viability, and also allow their delivery to a desired tissue or organ. Other applications include plant protection in agriculture, fermentation in the food industry, biocatalytic environmental remediation, and biosensing. Live cells that have been incorporated into nanofibers include bacteria and fungi. Nanofibers have served as scaffolds for stem cells seeded on a surface, to enable their delivery and application in tissue regeneration and wound healing. Viruses incorporated into nanofibers have been used in gene delivery, as well as in therapies against bacterial infections and cancers. Proteins (hormones, growth factors, and enzymes) and nucleic acids (DNA and RNA) have been incorporated into nanofibers, mainly to treat diseases and enhance their stability. To summarize, incorporation of biological products into nanofibers has numerous advantages, such as providing protection and facilitating controlled delivery from a solid form with a large surface area. Future studies should address the challenge of transferring nanofibers with biological products into practical and industrial use.

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Section: Polymers Natural Polymersmentioning

confidence: 99%

Electrospun Nanofibers as Carriers of Microorganisms, Stem Cells, Proteins, and Nucleic Acids in Therapeutic and Other Applications

Stojanov

Berlec

2020

Front. Bioeng. Biotechnol.

129

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“…The specific antibacterial activitywas measured using half maximal inhibitory concentration technique starting from the usedconcentration to prepare the blends (4 mg/ml). Figure (8) showed that the inhibition halo around small drop of used solution on the surface of agar after spread of Escherichia coliand incubated at 37°C for 24 hours. The highest inhibition of the bacteria was for Chitosan/PEOblend prepared at90:10 ratios withinhibition halo of 13mm at 40mg/ml concentration and still effective to 1/32 of the initial concentration (1.25mg/ml) but with less efficiency of halo diameter of 6mm (Table 2).…”

Section: Figure (7): Young Modulus For Chitosan/peo Blend With Peo Ratiomentioning

confidence: 99%

“…In addition, Chitosan is used in different biomedical applications due to its natural origin, biodegradability, biocompatibility, nontoxicity and antimicrobial activity. It is used in preventing wound infections, drug delivery, drug encapsulation, wound dressing and scaffolds for bone and nerve regeneration [8] . Also, blends-based chitosan are used as antimicrobial substance in food packaging [9] .…”

Section: Introductionmentioning

confidence: 99%

Investigation of Chitosan/PEO Reinforced with AgNPs for Antibacterial Activity Prepared by Solution Casting Method

Mahmood¹,

Jawad²

2019

ATMPH

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Background: Chitosan (CS) is a natural environmentally friendly polymer. It is a linear polysaccharide of random distribution. The aim of current study was to study the effect of weight ratioon structural properties of the chitosan/PEO polymer, using XRD and FTIR measurements,and to find the optimum ratio with the highest mechanical and antibacterial properties of chitosan:PEO blend, which was prepared by casting method. Methods: In this work, chitosan and chitosan/PEO blend with different PEO ratios (5, 10, 15, 20 and 25wt%) were prepared by solution casting method. The prepared samples were examined by x-ray diffraction (XRD), Fourier-transformed Infra-red spectrometer (FTIR) and tensile tester. Also,the antibacterial activitiesof prepared blends at different ratios were evaluated using half maximal inhibitory concentration technique against Escherichia coli and Staphylococcusaureus microorganisms. Results:The XRD and FTIR measurements indicated the formation of the blend by the obvious change in their patterns. The best mechanical properties appeared at 15% PEO ratio. It was found that the highest inhibition of bacteria for Chitosan/PEO blend was at 90:10 blend ratios. The blend has less effectiveness against Gram-positive (Staphylococcus aureus). The optimum blend sample, in terms of mechanical properties, was reinforced with different silver nanoparticles (AgNPs)(1, 2, 3, 4 and 5wt %) to find its effect on the structural and antibacterial activity.Conclusion: It was found that blend reinforced with AgNPs had clearly improved in its effectiveness as an antibacterial substance, especially against Gram-positive bacteria.

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“…Also, it has a strong and unique antibiotic activity [19] . It has been used in the treatment of hypertension [20] , respiratory infections [21] , healing wound injuries, and ulcers [22] . C. molmol effectively treated protozoa [23,24] and helminths [25][26][27] infections.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of Commiphora molmol extract loaded on chitosan nanofibers against experimental cryptosporidiosis

Fahmy

Aly

et al. 2021

Parasitologists United Journal

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Plant extracts have advantages over prescription drugs; not only are they more cost-effective, easier to produce and process, more available, and more effective, but they also tend to have fewer adverse effects [11] . Conjugation of plant extracts into nanostructured drug delivery systems, enhanced their therapeutic properties, potency, and safety of the active entity [12,13] . C. molmol, known in folklore medicine as Myrrh, is one of the effective plants

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Overview of Electrospinned Chitosan Nanofiber Composites for Wound Dressings

Cited by 12 publications

References 91 publications

Electrospun Nanofibers as Carriers of Microorganisms, Stem Cells, Proteins, and Nucleic Acids in Therapeutic and Other Applications

Electrospun Nanofibers as Carriers of Microorganisms, Stem Cells, Proteins, and Nucleic Acids in Therapeutic and Other Applications

Investigation of Chitosan/PEO Reinforced with AgNPs for Antibacterial Activity Prepared by Solution Casting Method

Therapeutic potential of Commiphora molmol extract loaded on chitosan nanofibers against experimental cryptosporidiosis

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