Overview of fetal growth retardation/restriction

Chia, Chun-Chieh; Huang, Soon-Cen

doi:10.1016/j.tjog.2014.01.003

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…3 Other maternal causes of IUGR described in the bibliography are hypertensive disorders of pregnancy, diabetic vasculopathy, chronic renal disease, collagen vascular disease and thrombophilia. 4 IUGR is defined as the failure of the fetus to reach its genetically established growth rate. It is annually related to 800,000 neonatal deaths worldwide 5 and can be classified as 'symmetrical' or 'asymmetrical', with different degrees of severity.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of early changes in fetoplacental hemodynamics in a diet-induced rabbit model of IUGR

López-Tello

Barbero

González-Bulnes³

et al. 2015

J Dev Orig Health Dis

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Intrauterine growth restriction (IUGR) is associated with adverse perinatal outcomes and late-onset diseases in offspring. Eating disorders, voluntary caloric restriction and maternal undernutrition can all induce IUGR but a relevant model is required to measure all its possible consequences. In this work, pregnant rabbits were used as an IUGR model. Control females (n=4) received ad libitum diet throughout pregnancy, whereas underfed females (n=5) were restricted to 50% of their daily requirements. Offspring size was measured by ultrasonography and in vivo at birth. Hemodynamic features of the umbilical cords and middle cerebral arteries (systolic peak velocity, end diastolic velocity, pulsatility index and resistance index) were characterized by Doppler ultrasonography. At day 21, maternal underfeeding resulted in a significant reduction of fetal size (occipito-nasal length). At birth, the size of kits from the underfed group was significantly lower (lower crown-rump length, biparietal and transversal thoracic diameters) and a reduced weight with respect to the control group. Feed restriction altered blood flow perfusion compared with does fed ad libitum (significant higher systolic peak, time-averaged mean velocities and lower end diastolic velocity). Fetuses affected by IUGR presented with compensative brain-sparing effects when compared with the control group. In conclusion, the present study supports using rabbits and the underfeeding approach as a valuable model for IUGR studies. These results may help to characterize IUGR alterations due to nutrient restriction of mothers in future research.

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Section: Introductionmentioning

confidence: 99%

“…Maternal undernutrition is considered a major cause of intrauterine growth restriction (IUGR) 3 . Other maternal causes of IUGR described in the bibliography are hypertensive disorders of pregnancy, diabetic vasculopathy, chronic renal disease, collagen vascular disease and thrombophilia 4 …”

Section: Introductionmentioning

confidence: 99%

Characterization of early changes in fetoplacental hemodynamics in a diet-induced rabbit model of IUGR

López-Tello

Barbero

González-Bulnes³

et al. 2015

J Dev Orig Health Dis

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“…Most fetuses with low weight are normal children with low genetic growth potential by statistical range. Although this potential is difficult to determine, some definitions are based on clinical variables and the measurement of fetus placental Doppler flowmetry [2][3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

Intrauterine growth restriction type 0: A comparison between deliveries at 37 weeks versus spontaneous labor

Treviño-Montemayor¹,

Guzmán-López²,

Soria-López³

et al. 2021

RMU

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Objective:The objective of the study was to evaluate obstetric outcomes in patients diagnosed with intrauterine growth restriction (IUGR) type 0 on termination of pregnancy at 37 weeks of gestation (WOG) compared with weekly flowmetry and spontaneous evolution or termination at 40 WOG. Materials and methods: An experimental, ambispective, longitudinal, comparative study carried out in a third level hospital in Northeast Mexico over a 1 year period. It included 80 patients forming two groups: patients diagnosed with IUGR type 0 with interruption of pregnancy at 37 WOG, or if older, at diagnosis, and patients with diagnosis of IUGR 0 with weekly monitoring and interruption at 40 WOG. Results: The demographic characteristics were similar. Gestational age at the time of termination of pregnancy was lower in Group A (38 vs. 39.2 WOG p < 0.001), and a higher frequency of labor induction was shown (p = 0.007). No significant difference was found in the number of cesarean sections between groups (p = 0.160). Neonatal results: weight of the newborn in Group A was lower (p = 0.017), the rest of the results were similar between groups. Conclusion: Continued pregnancy after week 37, with weekly monitoring, in patients diagnosed with IUGR type 0, decreases the number of patients undergoing induction of labor, the cesarean section index. It also allows greater weight gain of fetuses, without increasing the risk of disease progression.

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Role of cerebro-uterine ratio in late fetal growth restriction and in hypertensive disorders of pregnancy: A prospective observational study

Tyagi

Agarwal

Naik

et al. 2022

Preprint

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Objective: To evaluate the role Cerebro-uterine ratio (CUR) for prediction of adverse perinatal outcomes in pregnancies with late Fetal Growth Restriction (FGR) and Hypertensive Disorders of Pregnancy (HDP) Study design: Fifty women with FGR, fifty with HDP and 100 normal pregnancies between 34-38 weeks’ gestation were evaluated at a tertiary care centre by Ultrasound Doppler, CPR and CUR were determined and correlated with perinatal outcome. Results: UtA S/D and PI were significantly higher in cases as compared to controls in both groups (p<0.05). Only CUR was significantly lower in HDP cases compared to controls (p<0.001). CUR showed a higher influence on the occurrence of adverse perinatal outcomes in both groups compared to CPR. Conclusion: Uterine Artery Doppler is an important predictor of uteroplacental insufficiency. CUR can be a better predictor of adverse perinatal outcomes as compared to CPR in pregnancies complicated by HDP with or without FGR.

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Overview of fetal growth retardation/restriction

Cited by 3 publications

References 37 publications

Characterization of early changes in fetoplacental hemodynamics in a diet-induced rabbit model of IUGR

Characterization of early changes in fetoplacental hemodynamics in a diet-induced rabbit model of IUGR

Intrauterine growth restriction type 0: A comparison between deliveries at 37 weeks versus spontaneous labor

Role of cerebro-uterine ratio in late fetal growth restriction and in hypertensive disorders of pregnancy: A prospective observational study

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