Overview of Glass Molding Processes

Nelson, Jayson J.

doi:10.1007/978-981-15-4238-1_1

Cited by 3 publications

(4 citation statements)

References 1 publication

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“…Even though cheaper manufacturing has made thermoplastic polymers like poly(methyl methacrylate) and polydimethylsiloxane (PDMS) widely used materials for organ-on-chip fabrication, glass chips still have important advantages, e.g., low autofluorescence, high transparency, low drug absorption, scalability for high throughput designs and reusability due to chemical and thermal resistance during repeated harsh cleaning processes. Furthermore, new processes to fabricate microfluidic channels from glass make this material attractive (Wang et al, 2018). Islet on chip systems made from glass have been successfully fabricated and applied to investigate islet physiology and hormone secretion (Dishinger et al, 2009;Lu et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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A Parallel Perifusion Slide From Glass for the Functional and Morphological Analysis of Pancreatic Islets

Schulze

Mattern

Erfle

et al. 2021

Front. Bioeng. Biotechnol.

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An islet-on-chip system in the form of a completely transparent microscope slide optically accessible from both sides was developed. It is made from laser-structured borosilicate glass and enables the parallel perifusion of five microchannels, each containing one islet precisely immobilized in a pyramidal well. The islets can be in inserted via separate loading windows above each pyramidal well. This design enables a gentle, fast and targeted insertion of the islets and a reliable retention in the well while at the same time permitting a sufficiently fast exchange of the media. In addition to the measurement of the hormone content in the fractionated efflux, parallel live cell imaging of the islet is possible. By programmable movement of the microscopic stage imaging of five wells can be performed. The current chip design ensures sufficient time resolution to characterize typical parameters of stimulus-secretion coupling. This was demonstrated by measuring the reaction of the islets to stimulation by glucose and potassium depolarization. After the perifusion experiment islets can be removed for further analysis. The live-dead assay of the removed islets confirmed that the process of insertion and removal was not detrimental to islet structure and viability. In conclusion, the present islet-on-chip design permits the practical implementation of parallel perifusion experiments on a single and easy to load glass slide. For each immobilized islet the correlation between secretion, signal transduction and morphology is possible. The slide concept allows the scale-up to even higher degrees of parallelization.

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Section: Discussionmentioning

confidence: 99%

“…Therefore we introduced a tempering step during fabrication to smoothen the glass surface. The degree of smoothening achieved corresponded to polishing (Kubies et al, 2011;Wang et al, 2018) and allowed the precise and easy loading of single islets into the wells.…”

Section: Discussionmentioning

confidence: 99%

A Parallel Perifusion Slide From Glass for the Functional and Morphological Analysis of Pancreatic Islets

Schulze

Mattern

Erfle

et al. 2021

Front. Bioeng. Biotechnol.

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“…Having a high crystallization resistance (difference between the temperature of onset crystallization and glass transition temperature ΔT > 260 • C), the Ge 28 Sb 12 Se 60 glasses are suitable for fiber drawing 4,5 and for the formation of lenses, prisms, transparency windows by precision molding and extrusion methods. 6,7 The molding and extrusion processing of chalcogenide glasses are of considerable scientific and practical interest. Extrusion could be used for both perform and fiber fabrication.…”

Section: Introductionmentioning

confidence: 99%

“…The most studied and often used in the optical component design are glasses of the Ge 28 Sb 12 Se 60 composition. Having a high crystallization resistance (difference between the temperature of onset crystallization and glass transition temperature Δ T > 260°C), the Ge 28 Sb 12 Se 60 glasses are suitable for fiber drawing 4,5 and for the formation of lenses, prisms, transparency windows by precision molding and extrusion methods 6,7 …”

Section: Introductionmentioning

confidence: 99%

Numerical simulation of the Ge₂₈Sb₁₂Se₆₀ fiber extrusion process

Shabarova,

Stepanov,

Kirillov

et al. 2024

J Am Ceram Soc.

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A computational fluid dynamics model of the glass fiber extrusion process is proposed and verified. The model describes the homogeneous non‐isothermal motion of a viscous glass melt and the surrounding air in an experimental setup, taking into account the interface between the media and the movement of the metal rod. The unclad Ge28Sb12Se60 glass fibers for sensor applications are fabricated by extrusion. The validation of the developed model is performed based on the experimental data, including pressure values, temperature field in extrusion setup, and extruded glass mass outflow. Based on the proposed model, the thermal and kinetic conditions for the flow of Ge28Sb12Se60 glass during extrusion are numerically studied. The presented model could be used as a tool for analyzing the hydrodynamic and thermal processes during fiber extrusion.

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Thermal Bending Simulation and Experimental Study of 3D Ultra-Thin Glass Components for Smartwatches

Hu,

Sun,

Zhang

et al. 2024

Micromachines

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The heating system is an essential component of the glass molding process. It is responsible for heating the glass to an appropriate temperature, allowing it to soften and be easily molded. However, the energy consumption of the heating system becomes particularly significant in large-scale production. This study utilized G-11 glass for the simulation analysis and developed a finite element model for the thermal conduction of a 3D ultra-thin glass molding system, as well as a thermal bending model for smartwatches. Using finite element software, the heat transfer between the mold and the glass was modeled, and the temperature distribution and thermal stress under various processing conditions were predicted. The findings of the simulation, when subjected to a numerical analysis, showed that heating rate techniques significantly affect energy consumption. This study devised a total of four heating strategies. Upon comparison, optimizing with heating strategy 4, which applies an initial heating rate of 35 mJ/(mm2·s) during the initial phase (0 to 60 s) and subsequently escalates to 45 mJ/(mm2·s) during the second phase (60 to 160 s), resulted in a reduction of 4.396% in the system’s thermal output and a notable decrease of 7.875% in the heating duration, respectively. Furthermore, a single-factor research method was employed to study the forming process parameters. By comparing the numerical simulation results, it was found that within the temperature range of 615–625 °C, a molding pressure of 25–35 MPa, a heating rate of 1.5–2.5 °C/s, a cooling rate of 0.5–1 °C/s, and a pulse pressure of 45–55 Hz, the influence on residual stress and shape deviation in the glass was minimal. The relative error range was within the 20% acceptable limit, according to the experimental validation, which offered crucial direction and ideas for process development.

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Overview of Glass Molding Processes

Cited by 3 publications

References 1 publication

A Parallel Perifusion Slide From Glass for the Functional and Morphological Analysis of Pancreatic Islets

A Parallel Perifusion Slide From Glass for the Functional and Morphological Analysis of Pancreatic Islets

Numerical simulation of the Ge₂₈Sb₁₂Se₆₀ fiber extrusion process

Thermal Bending Simulation and Experimental Study of 3D Ultra-Thin Glass Components for Smartwatches

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Overview of Glass Molding Processes

Cited by 3 publications

References 1 publication

A Parallel Perifusion Slide From Glass for the Functional and Morphological Analysis of Pancreatic Islets

A Parallel Perifusion Slide From Glass for the Functional and Morphological Analysis of Pancreatic Islets

Numerical simulation of the Ge28Sb12Se60 fiber extrusion process

Thermal Bending Simulation and Experimental Study of 3D Ultra-Thin Glass Components for Smartwatches

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Product

Resources

About

Numerical simulation of the Ge₂₈Sb₁₂Se₆₀ fiber extrusion process