Overview of Herbal Therapy with Leave of Gynura procumbens (Lour.) Merr

Abstract

Plants are important source of traditional medicine that can be used to aid many type of illness. Gynura procumbens is one of the plants that are often used by Indonesian people as traditional medicine. Gynura procumbens exhibits antibacterial, anticancer, anti-hyperglycemic, antihypertensive, anti-inflammatory, antioxidant, cardioprotective, fertility enhancement, organ protective activity. This review aims to provide an overview on the relatedness of the identified bioactive compounds with the reported biological activities of Gynura procumbens leave and on the herbal therapy with leave of Gynura procumbens. Literature search is carried out with the help of two searching engines: PubMed and Science Direct. The searching was carried out with keyword: Gynura procumbens. From PubMed and Science Direct, 42 and 94 results were obtained respectively. There were 45 full text articles that meet systematic review criteria. The relevant information is compiled to illustrate that leave of Gynura procumbens is a potential natural source of compounds with various pharmacological actions. Polar, semi and nonpolar solvent can be used to extract the bioactive compounds from the leave of Gynura procumbens. The identified bioactive compounds belong to phenolic, flavonoid, coumaric acids, essential oils, carbohydrates and proteins. Most of the extracts show potent antioxidative activity. The bioactivities of the leave extract are associated with many diseases, such as diabetes, hypertension, cancer, obesity, etc. The herbal therapy with leave of Gynura procumbens can be appropriately applied in oral administration and topical application. Leave of Gynura procumbens is good resource for oral or topical herbal medicine/ingredient.

Experimental study of the hepatoprotective effect of the aqueous extract of Jinura Procumbens leaves on the model of fructose-induced non-alcoholic liver steatosis

“…Согласно результатов, полученных в других исследованиях экстракт из стеблей ДП снижает уровень ферментов и накопление липидов в печеночной ткани [14]. В нашем эксперименте интрагастральное введение данного препарата не оказало существенного влияния на показатели липидного спектра, однако привело к значимому уменьшению уровня АСТ в сыворотке лабораторных животных и препятствовало формированию гепатомегалии и характерных для стеатоза морфологических изменений в ткани печени.…”

“…В ряде исследований было найдено положительное влияние β-ситостеринов при метаболическом синдроме у пациентов с ожирением [9][10][11][12][13]. По данным литературы экстракт из стеблей ДП снижает уровень ферментов и накопление липидов в печеночной ткани [14].…”

Gynura procumbens ethanol extract improves vascular dysfunction by suppressing inflammation in postmenopausal rats fed a high-fat diet

“…It was shown in this study that GP extract supplementation could reduce the level of IL-6, TNF-a, and CRP in postmenopausal rats. A recent study suggested that steroid might be one class of anti-inflammatory compounds that suppressed the expression of inflammatory responses (Jarikasem et al 2013) by inhibiting the vasodilation, increasing vascular permeability that occurred following an inflammatory insult, and decreasing leukocyte migration into the inflamed sites (Timotius and Rahayu 2020).…”

Ethno-botanical and Pharmaceutical Properties of Mollucan Spinach (Gynura procumbens Lour. Merr)

“…The plant G. procumbens is utilized in traditional medicine for topical application in the treatment of different types of ailments (Krishnan et al, 2015). It is commonly used in treating rash, eruptive-fever, kidney disease, hypertension, migraine, diabetes mellitus, constipation and cancer (Roshida et al, 2009;Algariri et al, 2013;Timotius and Rahayu, 2020). Bioactive compounds such as flavonoids and glycosides were credited to be the active phytochemicals of the specie (Akowuah et al, 2002).…”

“…The small molecular weight compounds extracted from G. procumbens have been reported to display anti-cancer, antioxidant, antiinflammatory and anti-hyperglycemic activities. The benefits of the traditional use of G. procumbens have also been supported by the identification of several active chemical constituents including flavonoids (kaempferol, rutin and quercetin), chlorogenic acids, phenolics and steroids (Timotius and Rahayu, 2020). Gynura procumbens is a new source of potential herbs in the herbal industry.…”