Overview of Human Cytomegalovirus Pathogenesis

PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling

“…Forty to 70% of adults in developed countries are chronically infected with HCMV, and infection increases with age [2,3]. HCMV infection is normally well tolerated except when individuals are immunocompromised [4]. Immune responses control infection; however, HCMV evades these responses to establish lifelong infections [5].…”

Cryo-Electron Microscopy Structure and Interactions of the Human Cytomegalovirus gHgLgO Trimer with Platelet-Derived Growth Factor Receptor Alpha

“…Human cytomegalovirus (HCMV) is a member of the betaherpesvirus family which is widespread in the human population and responsible for a significant health burden in vulnerable groups ( 1 – 3 ). While HCMV infection is generally benign, infections during pregnancy can result in transmission to the fetus and cause birth defects that affect ∼0.5% of newborns ( 2 , 4 ).…”

“…While HCMV infection is generally benign, infections during pregnancy can result in transmission to the fetus and cause birth defects that affect ∼0.5% of newborns ( 2 , 4 ). Congenital HCMV infections can damage the nervous system of the developing fetus and account for ∼25% of children with sensorineural hearing loss in the United States ( 3 ). In addition, infections in immunocompromised transplant recipients affect up to 15 to 30% of high-risk solid organ transplants and can result in acute and chronic graft rejection.…”

Human Cytomegalovirus Host Interactions: EGFR and Host Cell Signaling Is a Point of Convergence Between Viral Infection and Functional Changes in Infected Cells

“…The HCMV infection elicits a robust immune response (Gerna et al, 2005;Sinzger et al, 2006;Mason et al, 2012). However, symptomatic infections largely only occur in immunocompromised patients (Stagno et al, 1986;Bentz et al, 2006;Arvin, 2007;Nogalski et al, 2014;Fulkerson et al, 2021). Thus, the immune response keeps the virus under tight control in healthy individuals.…”

“…Human cytomegalovirus (HCMV) infection is a significant public health threat worldwide (Stagno et al, 1986;Bentz et al, 2006;Arvin, 2007;Nogalski et al, 2014;Fulkerson et al, 2021). HCMV is a leading cause of morbidity and mortality in developing fetuses and the immunocompromised population (Stagno et al, 1986;Bentz et al, 2006;Arvin, 2007;Nogalski et al, 2014;Fulkerson et al, 2021). HCMV infection in neonates is the leading cause of congenital central nervous system damage and deafness (Boppana et al, 2011).…”