Overview of Methamphetamine-Associated Pulmonary Arterial Hypertension

Charoenpong, Prangthip; Hall, Nicole M.; Keller, Courtney M.; Ram, Anil Kumar; Murnane, Kevin S.; Goeders, Nicholas E.; Dhillon, Navneet Kaur; Walter, Robert E.

doi:10.1016/j.chest.2024.01.014

Cited by 1 publication

(1 citation statement)

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“…METH, commonly referred to as crystal meth, is a synthetic stimulant drug that belongs to the amphetamine class of compounds that have an exciting effect on the central nervous system, resulting in increased heart rate, increased blood pressure, increased alertness and energy, and appetite suppression ( 49 , 50 ). The prolonged use of METH and its sudden withdrawal lead to substance withdrawal syndrome, encompassing symptoms such as anxiety, depression, and other manifestations.…”

Section: Overview Of the Connection Between Gut Microbiota And Depres...mentioning

confidence: 99%

Current landscape of fecal microbiota transplantation in treating depression

Zhang,

Bi,

Zhang

et al. 2024

Front. Immunol.

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Depression, projected to be the predominant contributor to the global disease burden, is a complex condition with diverse symptoms including mood disturbances and cognitive impairments. Traditional treatments such as medication and psychotherapy often fall short, prompting the pursuit of alternative interventions. Recent research has highlighted the significant role of gut microbiota in mental health, influencing emotional and neural regulation. Fecal microbiota transplantation (FMT), the infusion of fecal matter from a healthy donor into the gut of a patient, emerges as a promising strategy to ameliorate depressive symptoms by restoring gut microbial balance. The microbial-gut-brain (MGB) axis represents a critical pathway through which to potentially rectify dysbiosis and modulate neuropsychiatric outcomes. Preclinical studies reveal that FMT can enhance neurochemicals and reduce inflammatory markers, thereby alleviating depressive behaviors. Moreover, FMT has shown promise in clinical settings, improving gastrointestinal symptoms and overall quality of life in patients with depression. The review highlights the role of the gut-brain axis in depression and the need for further research to validate the long-term safety and efficacy of FMT, identify specific therapeutic microbial strains, and develop targeted microbial modulation strategies. Advancing our understanding of FMT could revolutionize depression treatment, shifting the paradigm toward microbiome-targeting therapies.

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Section: Overview Of the Connection Between Gut Microbiota And Depres...mentioning

confidence: 99%